Navigation Links
UCSB chemists make discovery that may lead to drug treatment possibilities for Alzheimer's
Date:2/10/2011

(Santa Barbara, Calif.) UC Santa Barbara scientists have made a discovery that has the potential for use in the early diagnosis and eventual treatment of plaque-related diseases such as Alzheimer's disease and Type 2 diabetes. Their work is published in a recent issue of Nature Chemistry.

The amyloid diseases are characterized by plaque that aggregates into toxic agents that interact with cellular machinery, explained Michael T. Bowers, lead author and professor in the Department of Chemistry and Biochemistry. Other amyloid diseases include Parkinson's disease, Huntington's disease, and atherosclerosis. Amyloid plaques are protein fibrils that, in the case of Alzheimer's disease, develop prior to the appearance of symptoms.

"The systems we use are model systems, but the results are groundbreaking," said Bowers. He explained that his research provides the first examples of the conversion of randomly assembled aggregates of small peptides into ordered beta sheets that comprise fibrils. Fibrils are the final structural state of the aggregation process.

In the article, Bowers describes how understanding the fundamental forces that relate aggregation, shape, and biochemistry of soluble peptide aggregates is central to developing diagnostic and therapeutic strategies for amyloid diseases.

Bowers and his research team used a method called ion-mobility spectrometry-mass spectrometry (IMS-MS). This method enabled the team to deduce the peptide self-assembly method. They then examined a series of amyloid-forming peptides clipped from larger peptides or proteins associated with disease.

Bowers explained that IMS-MS has the potential to open new avenues for investigating the pathogenic mechanisms of amyloid diseases, their early diagnosis and eventual treatment.

The first author of the paper is Christian Blieholder, a Humbolt Postdoctoral Fellow at UCSB. Thomas Wyttenbach, UCSB associate researcher, is a co-author. Nicholas F. Dupuis, who was a Ph.D. student at UCSB at the time of the research, is also a co-author; he is now a postdoctoral fellow at the University of Colorado.


'/>"/>

Contact: Gail Gallessich
gail.g@ia.ucsb.edu
805-893-7220
University of California - Santa Barbara
Source:Eurekalert  

Related biology news :

1. UC Riverside biochemists devise method for bypassing aluminum toxicity effects in plants
2. JHU chemists devise self-assembling organic wires
3. Clemson chemists present revolutionary teaching concepts
4. UConn chemists find secret to increasing luminescence efficiency of carbon nanotubes
5. Dancing adatoms help chemists understand how water molecules split
6. Iowa State, Ames Lab chemists discover how antiviral drugs bind to and block flu virus
7. U of C chemists discover recipe to design a better type of fuel cell
8. UNH chemists create molecule with promising semiconductor properties
9. Behavior of single protein observed in unprecedented detail by Stanford chemists
10. Chemists influence stem-cell development with geometry
11. Colorado State University biochemists study how chromosomes unravel to let genes do their jobs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCSB chemists make discovery that may lead to drug treatment possibilities for Alzheimer's
(Date:3/22/2017)... 21, 2017 Optimove , provider ... retailers such as 1-800-Flowers and AdoreMe, today announced ... and Replenishment. Using Optimove,s machine learning algorithms, these ... and replenishment recommendations to their customers based not ... of customer intent drawn from a complex web ...
(Date:3/20/2017)... , March 20, 2017 At this year,s CeBIT ... -based biometrics manufacturer DERMALOG. The Chancellor came to the DERMALOG stand together ... is this year,s CeBIT partner country. At the largest German biometrics company ... use: fingerprint, face and iris recognition as well as DERMALOG´s multi-biometrics system.   ... ...
(Date:3/16/2017)... , March 16, 2017 CeBIT 2017 - Against identity fraud ... Continue Reading ... Used combined in one project, multi-biometric solutions provide a ... Used combined ... ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... 2017  UBM and the Massachusetts Medical Device ... partnership and the third annual Massachusetts Medtech Week. Massachusetts ... st Annual MassMEDIC Conference held in conjunction ... 2017. MassMEDIC will feature a ... and CEO, Scott Whitaker , at its ...
(Date:3/22/2017)... -- MarketNewsUpdates.com News Commentary  ... The traditional ways to treat ... of late due to the rise of the opioid crisis. ... impact on patient,s quality of life as Biotech and Pharma ... forms of opioid formulations that prevent abuse. Biotech and Pharma ...
(Date:3/22/2017)... Grand Bahama (PRWEB) , ... March 21, 2017 , ... ... free educational seminar as part of their live events series, “Stem Cell Therapy: The ... stem cell facility under the 2013 Stem Cell Research and Therapy Act, ...
(Date:3/22/2017)... ... March 21, 2017 , ... Watson-Marlow ... pump with patented ReNu single-use (SU) cartridge technology. Engineered by the world ... pumps in SU tangential flow filtration (TFF), virus filtration (VF) and high-performance ...
Breaking Biology Technology: