Navigation Links
UCSB chemists make discovery that may lead to drug treatment possibilities for Alzheimer's
Date:2/10/2011

(Santa Barbara, Calif.) UC Santa Barbara scientists have made a discovery that has the potential for use in the early diagnosis and eventual treatment of plaque-related diseases such as Alzheimer's disease and Type 2 diabetes. Their work is published in a recent issue of Nature Chemistry.

The amyloid diseases are characterized by plaque that aggregates into toxic agents that interact with cellular machinery, explained Michael T. Bowers, lead author and professor in the Department of Chemistry and Biochemistry. Other amyloid diseases include Parkinson's disease, Huntington's disease, and atherosclerosis. Amyloid plaques are protein fibrils that, in the case of Alzheimer's disease, develop prior to the appearance of symptoms.

"The systems we use are model systems, but the results are groundbreaking," said Bowers. He explained that his research provides the first examples of the conversion of randomly assembled aggregates of small peptides into ordered beta sheets that comprise fibrils. Fibrils are the final structural state of the aggregation process.

In the article, Bowers describes how understanding the fundamental forces that relate aggregation, shape, and biochemistry of soluble peptide aggregates is central to developing diagnostic and therapeutic strategies for amyloid diseases.

Bowers and his research team used a method called ion-mobility spectrometry-mass spectrometry (IMS-MS). This method enabled the team to deduce the peptide self-assembly method. They then examined a series of amyloid-forming peptides clipped from larger peptides or proteins associated with disease.

Bowers explained that IMS-MS has the potential to open new avenues for investigating the pathogenic mechanisms of amyloid diseases, their early diagnosis and eventual treatment.

The first author of the paper is Christian Blieholder, a Humbolt Postdoctoral Fellow at UCSB. Thomas Wyttenbach, UCSB associate researcher, is a co-au
'/>"/>

Contact: Gail Gallessich
gail.g@ia.ucsb.edu
805-893-7220
University of California - Santa Barbara
Source:Eurekalert  

Page: 1 2

Related biology news :

1. UC Riverside biochemists devise method for bypassing aluminum toxicity effects in plants
2. JHU chemists devise self-assembling organic wires
3. Clemson chemists present revolutionary teaching concepts
4. UConn chemists find secret to increasing luminescence efficiency of carbon nanotubes
5. Dancing adatoms help chemists understand how water molecules split
6. Iowa State, Ames Lab chemists discover how antiviral drugs bind to and block flu virus
7. U of C chemists discover recipe to design a better type of fuel cell
8. UNH chemists create molecule with promising semiconductor properties
9. Behavior of single protein observed in unprecedented detail by Stanford chemists
10. Chemists influence stem-cell development with geometry
11. Colorado State University biochemists study how chromosomes unravel to let genes do their jobs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCSB chemists make discovery that may lead to drug treatment possibilities for Alzheimer's
(Date:12/22/2014)... 2014  NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) ... the growing mobile commerce market, announces it has retained famous ... the 2015 International CES debut of the Wocket™ biometric smart ... at the NXT-ID booth January 6th and 7 th , ...
(Date:12/19/2014)... , Dec. 18, 2014  23andMe, Inc., the leading personal ... pinpoints fine-scale differences in genetic ancestry of individuals from across ... immigrants first arrived more than four hundred years ago, ... meeting place for peoples from different continents. This study illuminates ...
(Date:12/17/2014)... 16, 2014 Valencell, a leader in performance biometric ... to industry leaders such as Intel, Jabra, Atlas, and ... wearable products. These products will be showcased at CES ... Vegas . "Our partners choose ...
Breaking Biology News(10 mins):NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 423andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2
... In a field of maize, no two leafy stalks ... they grew from seed cells with identical genetic material. ... is a longstanding biology puzzle. Now, a distinguished team of ... University (FAMU) will work on that puzzle with a new, ...
... how changes in both behavior and genetics led ... ( Astyanax mexicanus ) from its sighted, surface-dwelling ... 2010 online edition of the journal Current Biology, ... Yoshizawa, and pela Gorički, and Assistant Professor Daphne ...
... University and Women & Infants Hospital have invented the first ... new means for conducting fertility research and could also yield ... the lab-grown organ to mature human eggs. "An ovary ... the first time that anyone has created a 3-D tissue ...
Cached Biology News:How cells manage their genes focus of $1.4 million NSF grant to Florida State 2How cells manage their genes focus of $1.4 million NSF grant to Florida State 3Adapting to darkness: How behavioral and genetic changes helped cavefish survive extreme environment 2Adapting to darkness: How behavioral and genetic changes helped cavefish survive extreme environment 3Researchers build 'artificial ovary' to develop oocytes into mature human eggs 2Researchers build 'artificial ovary' to develop oocytes into mature human eggs 3
(Date:1/22/2015)... Calif. , Jan. 22. 2015  Varian Medical Systems (NYSE: ... software, has been honored for its commitment to sustainability with ... companies. Varian is the highest ranked healthcare equipment company among ... today during the World Economic Forum at Davos, ...
(Date:12/25/2014)... The report “Service Quality Management and Telco Customer Experience ... Global Advancements, Worldwide Forecasts & Analysis (2014-2019)” defines and ... of revenues. , Browse 152 market data tables, ... on “Service Quality Management (SQM) and Telco Customer Experience ...
(Date:12/24/2014)... 2014  Vermillion, Inc. (Nasdaq:   VRML), a bio-analytical ... that the Company closed its previously announced private ... Jack W. Schuler , Birchview Fund LLC and ... before offering expenses.  The proceeds will be used ...
(Date:12/24/2014)... GMO corn cases filed across the United ... process of being consolidated in a Kansas federal court for ... MIR 162 Corn Litigation, MDL No. 2591 in the U.S. ... the Syngenta GMO corn multidistrict litigation (MDL) has been handed ...
Breaking Biology Technology:Varian Honored Among World's 100 Most Sustainable Corporations 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2
... (Nasdaq: EVVV ),a global endovascular device ... from the U.S. Food & Drug Administration (FDA) ... angioplasty balloon,catheters. ev3 expects to begin full ... globally in January 2009. , Robert ...
... KNDL ) a,leading, global full-service clinical research ... annual Raymond James,Boston Fall Investors Conference. The conference will ... floor, in Boston on Dec. 11, 2008. Kendle,s,presentation is ... , (Logo: ...
... BioMarin Pharmaceutical,Inc. (Nasdaq: BMRN ) ... a division,of Merck KGaA, Darmstadt, Germany, has ... the treatment of,hyperphenylalaninemia (HPA) in phenylketonuria (PKU) ... Merck Serono estimates that there are,approximately ...
Cached Biology Technology:ev3 Inc. Receives FDA Clearance to Market EverCross and NanoCross Peripheral Angioplasty Balloons 2ev3 Inc. Receives FDA Clearance to Market EverCross and NanoCross Peripheral Angioplasty Balloons 3Kendle to Present at the 2008 Raymond James Boston Fall Investors Conference 2Kuvan Receives Marketing Approval in the European Union 2Kuvan Receives Marketing Approval in the European Union 3Kuvan Receives Marketing Approval in the European Union 4
Ms anti-Cyclophilin D...
Protein Kinase D2 Immunogen: Human protein kinase D2. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Request Info...
Immunogen: Recombinant rabbit tryptophan hydroxylase, isolated as inclusion bodies from E. coli and purified by preparative SDS-PAGE. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: