Navigation Links
UCSB biomedical scientist discovers a new method to increase survival in sepsis
Date:11/25/2013

(Santa Barbara, Calif.) Sepsis, the body's response to severe infections, kills more people than breast cancer, prostate cancer and HIV/AIDS combined. On average, 30 percent of those diagnosed with sepsis die.

A new study conducted by Jamey Marth, director of UC Santa Barbara's Center for Nanomedicine and professor of the Sanford-Burnham Medical Research Institute, reports a new method to increase survival in sepsis. The results appear today in the Proceedings of the National Academy of Sciences.

Building on earlier work in which Marth's team revealed the biological purpose of the Ashwell-Morell receptor (AMR) in the liver, the new discovery not only describes the AMR's protective mechanism, but also outlines a way to leverage it for therapeutic use. Sepsis often triggers widespread blood coagulation and thrombosis, which can lead to organ failure and death.

The researchers found that the AMR protects the host by the rapid removal of the prothrombotic components normally present in the bloodstream, including platelets and specific coagulation factors that contribute to the formation of blood clots. The study elucidates this mechanism of AMR function in mitigating the lethal effects of excessive blood coagulation and thrombosis in sepsis.

The key is neuraminidase, an enzyme that is present in many pathogenic microorganisms, such as Streptococcus pneumoniae, the bacteria used in this study, which remains one of the top five causes of death worldwide. Pathogens use neuraminidase to get into cells, but once the pathogen enters the bloodstream, the enzyme then remodels the surface of platelets and other glycoproteins in circulation. This remodeling signals the AMR to remove those platelets and coagulation factors before they have a chance to contribute to the lethal coagulopathy of sepsis.

"It's a highly conserved protective mechanism never before identified," said Marth, who is also Carbon Professor of Biochemistry and Molecular Biology and Mellichamp Professor of Systems Biology at UCSB. "The host has evolved this protective mechanism over millions of years as a way to compensate for the lethal impact of the pathogen on our coagulation system."

The scientists wondered what would happen if they could pre-activate and augment AMR function in the early phases of sepsis. To answer that question, they infected mice with Streptococcus pneumoniae and then gave them a single dose of neuraminidase. "We were able to increase survival twofold," said Marth. "It's remarkable, and because we see the same mechanism active in human sepsis there is excitement by the potential of this approach to save millions of lives."

In teasing out the details of the AMR's protective mechanism, Marth and his colleagues learned that the receptor has the capability to selectively identify and remove certain blood components that could harm the host if they contributed to blood clotting in sepsis.

Although some scientists have suggested that little may be gained from research on sepsis in non-human species, the study by the Marth team discloses a mechanism of host protection that is conserved through mammalian evolution and which can be easily manipulated. The fact that this mechanism is imperceptible to studies of genomic variation and gene expression may explain why others have not discovered it earlier. "Much of biomedical research is focused on the gene. In our research, it was the study of metabolism that provided the key," explained Marth.

"Because it appears that the same protective mechanism exists in humans, investors have already contacted us about moving this forward into clinical trials," Marth said. "It's estimated that 50 to 100 million people around the world have sepsis each year, and we can now imagine a simple effective treatment consisting of a non-refrigerated enzyme mixed with saline, placed in a syringe and injected intravenously. This has the potential to translate into saved lives among those in the developed and undeveloped world."


'/>"/>

Contact: Julie Cohen
julie.cohen@ia.ucsb.edu
805-893-7220
University of California - Santa Barbara
Source:Eurekalert  

Related biology news :

1. Biomedical Advanced Research and Development Authority (BARDA) Exercises Option with Pfenex Inc. To Extend Contract and Increase Funding for the Development of a Recombinant Protective Antigen (rPA) Based Anthrax Vaccine
2. NIH announces awards to strengthen the biomedical research workforce
3. MARC travel awards announced for the 2013 Biomedical Engineering Society annual meeting
4. TGen President Dr. Jeffrey Trent speaks at Brookings Institution biomedical conference
5. Fluke Biomedical launches portable, feature-rich ProSim 3 and 2 Vital Signs Simulators
6. Biomedical research revealing secrets of cell behavior
7. New FASEB analysis documents impact of budget cuts on biomedical research
8. Core for Life, a new European alliance in biomedical research
9. WPI Biomedical Technology in final 4 of international business plan contest
10. Breakthrough study opens door to broader biomedical applications for Raman spectroscopy
11. Vilcek Prize for Biomedical Science split between 2 giants of immunology
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCSB biomedical scientist discovers a new method to increase survival in sepsis
(Date:11/21/2016)... , Nov. 21, 2016   Neurotechnology ... object recognition technologies, today announced that the MegaMatcher ... cards was submitted for the NIST Minutiae ... passed all the mandatory steps of the evaluation ... is a continuing test of fingerprint templates used ...
(Date:11/16/2016)... CLARA, Calif. , Nov. 16, 2016 ... enhancing user experience and security for consumer electronics, ... for the financial and retail industry, today announced ... secure and convenient way to authenticate users of ... uses Sensory,s TrulySecure™ software which requires ...
(Date:11/14/2016)... Nov. 14, 2016  Based on its ... Frost & Sullivan recognizes FST Biometrics with ... for Visionary Innovation Leadership. FST Biometrics emerged ... identification market by pioneering In Motion Identification ... instant, seamless, and non-invasive verification. This patented ...
Breaking Biology News(10 mins):
(Date:12/9/2016)... December 9, 2016 The research ... five players in the  Global Label-Free Array Systems Market ... market in 2015. Players such as Biacore, Agilent Technologies, ... dominant in the global market due to their unmatched ... innovation. Product upgrades and timely product launches are expected ...
(Date:12/9/2016)... , Dec. 9, 2016 China Cord Blood Corporation ... China,s leading provider of cord blood collection, ... services, today announced the results of its 2016 Annual General ... Kong S.A.R., China . ... ratified the re-appointment of KPMG Huazhen LLP as the independent ...
(Date:12/9/2016)... According to a new market research report "Oligonucleotide Synthesis Market ... (Research, PCR, Gene, DNA, NGS, Diagnostic, RNAI), End user (Academic, Pharmaceutical, ... is expected to reach USD 2.20 Billion by 2021 from USD ... forecast period. Continue Reading ... ...
(Date:12/8/2016)... LONDON , Dec. 8, 2016 This report ... following Product Segments: Acid Based (Humic, Amino, & Fulvic), Extract ... by the following Crop Types: Ornamental & Turf, Row Crops, ... US, Canada , Japan ... , Latin America , and Rest of ...
Breaking Biology Technology: