Navigation Links
UCR researchers propose minocycline as a promising drug for patients with Fragile X syndrome
Date:10/3/2008

dea that mental impairment cannot be treated."

"The work could lead to the first treatment that actually targets the underlying defect in Fragile X syndrome and not just the symptoms," Dr. Paribello said.

UCR's Douglas Ethell, an assistant professor of biomedical sciences, noted that effective therapies for Fragile X syndrome are few and far between. "This is a good time for identifying highly effective therapeutic strategies that might work in Fragile X patients," he said. "We are excited that our research has the potential to affect many lives."

Fragile X affects 1 in 4000 males and 1 in 6000 females of all races and ethnic groups. About 1 in 259 women carry Fragile X and could pass it to their children. About 1 in 800 men carry Fragile X; their daughters will also be carriers.

Minocycline belongs to a group of antibiotics that has been used in people for more than fifty years to treat Lyme disease, acne, and other skin infections.

Minocycline may have beneficial effects in other disorders where higher-than-normal brain levels of MMP-9 are found. It is currently under study for treating rheumatoid arthritis, multiple sclerosis (MS), Parkinson's disease, and several other neurodegenerative conditions.

"In the future, new compounds that more specifically target MMP-9 can be developed and tested," Douglas Ethell said.

Next in their research, the Ethells and their colleagues plan to refine the therapeutic strategy in Fragile X mice to determine the optimal age, if any, to administer minocycline. They will also explore other MMP inhibitors that may be more effective than minocycline.

"We will investigate whether a combination of MMP inhibitors with other drugs, such as fenobam, can help mature the synapses in Fragile X mice," Iryna Ethell said.


'/>"/>

Contact: Iqbal Pittalwala
iqbal@ucr.edu
951-827-6050
University of California - Riverside
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Childrens National researchers develop novel anti-tumor vaccine
2. Case Western Reserve University researchers track Chernobyl fallout
3. Researchers develop new self-training gene prediction program for fungi
4. UI researchers find potentially toxic substance present in Chicago air
5. Researchers study how pistachios may improve heart health
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study acoustic communication in deep-sea fish
8. Researchers note differences between people and animals on calorie restriction
9. Researchers find an essential gene for forming ears of corn
10. Researchers find animal with ability to survive climate change
11. NC State researchers get to root of parasite genome
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCR researchers propose minocycline as a promising drug for patients with Fragile X syndrome
(Date:7/31/2014)... A first-of-its-kind study of bigeye tuna movements in ... of the Large Pelagics Research Center at the University ... fish cover a wide geographical range with pronounced north-south ... they favor a high-use area off Cape Hatteras southwest ... used a new approach to study one of the ...
(Date:7/31/2014)... Science Foundation (NSF), counters a widely-held scientific view ... instead that certain Arctic lakes store more greenhouse ... , The study, published this week in the ... which occur as permafrost thaws and creates surface ... what was previously frozen land into lakes. , ...
(Date:7/31/2014)... 3,000 genes to the earliest common ancestor of ... created an extensive "Tree of Lepidoptera" in the ... , Among the study,s more surprising findings: ... than to large ones, which completely changes scientists, ... found that some insects once classified as moths ...
Breaking Biology News(10 mins):Study of bigeye tuna in Northwest Atlantic uses new tracking methods 2Study of bigeye tuna in Northwest Atlantic uses new tracking methods 3Certain Arctic lakes store more greenhouse gases than they release 2UF study advances 'DNA revolution,' tells butterflies' evolutionary history 2UF study advances 'DNA revolution,' tells butterflies' evolutionary history 3
... health in the past, and are bound to do ... example, led to many illnesses and deaths from breathing ... vying for scarce food, shelter, and work. Future ... ramifications. Following a request from Gov. Christine Gregoire, Washington ...
... colds? How do viruses get into cells? In pursuing this ... since 1997, and his team have pioneered research in this ... the Swiss Nobel Prize in Bern, Switzerland. This award is ... well a confirmation of our long years of work, and ...
... #1 FOR IMMEDIATE RELEASE Spinning a new role ... and DVDs and the hardware used to play these popular ... a new generation of portable, inexpensive instruments for home health ... in the Oct. 15 issue of ACS Analytical Chemistry, a ...
Cached Biology News:University and state agencies to forecast local health effects of climate change 2University and state agencies to forecast local health effects of climate change 3University and state agencies to forecast local health effects of climate change 4ETH Zurich professor Ari Helenius awarded Benoist Prize 2American Chemical Society's Weekly PressPac -- Sept. 19, 2007 2American Chemical Society's Weekly PressPac -- Sept. 19, 2007 3American Chemical Society's Weekly PressPac -- Sept. 19, 2007 4American Chemical Society's Weekly PressPac -- Sept. 19, 2007 5American Chemical Society's Weekly PressPac -- Sept. 19, 2007 6American Chemical Society's Weekly PressPac -- Sept. 19, 2007 7American Chemical Society's Weekly PressPac -- Sept. 19, 2007 8
(Date:7/31/2014)... Dallas, Texas (PRWEB) August 01, 2014 ... Global and China Polyurethane Resin Industry” is ... Polyurethane Resin market. The report introduces Polyurethane ... application, and industry chain structure and industry ... analysis, including China’s domestic market as well ...
(Date:7/31/2014)... July 31, 2014 Today BioSpace , the leading life ... map campaign spotlighting the life sciences community in Illinois ... Kansas , Michigan , Minnesota ... Ohio and Wisconsin . ... percent of all job postings on BioSpace originating in this region in ...
(Date:7/31/2014)... CHICAGO , July 31, 2014 Nearly ... 65 th Annual Meeting & Clinical Lab Expo ... The meeting featured never-before-seen breakthroughs in diagnostic research and ... treatment they need. As of Wednesday, July ... 2014 AACC Annual Meeting & Clinical Lab Expo, with ...
(Date:7/31/2014)... reason people over 60 are not donor candidates for ... with time, making the elderly prone to life-threatening infection ... team now has discovered a reason why. , "We ... of blood-forming cells to maintain blood production over time ... that could be restored for rejuvenation therapies," said Emmanuelle ...
Breaking Biology Technology:Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 2Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 3Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 4Midwest Biotech Leaders Featured On BioSpace Map 2Research on Digital Health, Alzheimer's, Ebola Draws Nearly 20,000 Attendees to 2014 AACC Annual Meeting & Clinical Lab Expo 2Research on Digital Health, Alzheimer's, Ebola Draws Nearly 20,000 Attendees to 2014 AACC Annual Meeting & Clinical Lab Expo 3Key to aging immune system is discovered 2
... 9 Burrill Merchant Banking acted as,exclusive financial ... partnering of bilastine with the Menarini Group (Italy). ... bilastine rights in Europe,and other regions to Menarini ... is a new highly selective H1 antihistamine for ...
... 9 Barr Pharmaceuticals,Inc. (NYSE: BRL ) ... a challenge of the patents listed by Sanofi-Aventis ... Solution), 5mg/mL,Injectable., Barr filed an Abbreviated New ... a generic Eloxatin product with the U.S.,Food & ...
... Quintiles,Transnational Corp. today announced the expansion and consolidation ... (CDS) units,in Beijing to accommodate their growing business ... facility, with more than 17,000,square feet of space, ... Beijing, about,one block from the previous lab site ...
Cached Biology Technology:Burrill Merchant Banking Advises Faes Farma on Bilastine Licensing Agreement 2Barr Confirms Patent Challenge of Eloxatin(R) Injectable, 5mg/mL 2Barr Confirms Patent Challenge of Eloxatin(R) Injectable, 5mg/mL 3Quintiles Central Lab, Clinical Development in China to Expand, Relocate to New Facility 2
... Loading Buffer contains a precipitant to ensure that ... tracking dye to allow the user to follow ... ReddyRun™: ABgene ® s proprietary mixture ... same buffer composition used in ReddyRun™ molecular weight ...
... Insulin exerts its ... the insulin receptor, a ... of two Alpha subunits ... arranged in the following ...
... Gel loading buffer is especially formulated ... of nucleic acids. The gel loading solution ... sucrose to add density and facilitate sample ... nucleases that require divalent cations and SDS ...
... solution, Type I is ... and agarose gel electrophoresis ... offers the advantage of ... blue and xylene cyanole). ...
Biology Products: