Navigation Links
UCR researcher identifies mechanism malaria parasite uses to spread among red blood cells
Date:2/18/2010

ss to the genes. The transcription factors then convert these genes into protein.

While in humans such eviction of nucleosomes is specific to only some sections of the DNA strand and performed only when needed, in Plasmodium the situation is vastly different.

Le Roch's experiments in the lab show that 18 hours after Plasmodium enters a red blood cell, a huge eviction of nucleosomes occurs in the Plasmodium DNA. Gene transcription throughout the genome follows; after multiplication into up to 32 daughter cells, the newly-formed parasites are ready to exit the red blood cell and invade new ones about 18 hours later.

"We found in our experiments that histones are massively evicted everywhere in the Plasmodium genome, resulting in most of the Plasmodium genes to be transcribed at once," Le Roch said. "If we can find a candidate enzyme that can regulate this massive histone eviction, we could halt or greatly limit Plasmodium replication."

Study results appear this month in the journal Genome Research.

"Dr. Le Roch's findings document a global mechanism mediating significant changes in gene expression as the parasites transition through developmental stages in the human hosts," said Anthony A. James, a distinguished professor of microbiology & molecular genetics and molecular biology & biochemistry at UC Irvine, who was not involved in the research. "As well as being a major basic discovery, this provides a basis for probing the mechanisms for novel drug development."


'/>"/>

Contact: Iqbal Pittalwala
iqbal@ucr.edu
951-827-6050
University of California - Riverside
Source:Eurekalert  

Page: 1 2

Related biology news :

1. MDC researchers link protein tether to touch perception
2. Caltech researchers presenting at AAAS Meeting
3. Researchers develop standard of care for breast cancer survivors with lymphedema
4. U-M researchers find key interaction that controls telomeres
5. UWM researcher predicts stem cell fate with software
6. Researchers identify mechanism for Frank-Ter Haar syndrome
7. OHSU researchers discover cellular mechanism that protects against disease
8. Cameras of the future: heart researchers create revolutionary photographic technique
9. Cleveland Clinic, CWRU dental researcher finds switch that turns on the spread of cancer
10. Caltech researchers obtain first brain recordings from behaving fruit flies
11. Researchers envision high-tech applications for multiferroic crystals
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCR researcher identifies mechanism malaria parasite uses to spread among red blood cells
(Date:7/27/2015)... , July 27, 2015  Synaptics Inc. (NASDAQ: ... interface solutions, today announced that Huawei has selected ... solution for its stylish smartwatch. Huawei chose the ... reliability, low power and highly responsive human interface ... Huawei designers also required a classic round watch ...
(Date:7/21/2015)... Today, ZTE announced its Android smartphone Axon, featuring FPC,s ... in 2015 that relate to sales of FPC1025 for this smartphone ... MSEK for 2015. Jörgen Lantto, CEO of FPC, comments: ... China and we are proud that ... Axon , its first smartphone ...
(Date:7/13/2015)... SAN JOSE, Calif. , July 13, 2015 ... the leading developer of human interface solutions, today ... second generation touch and display driver integration (TDDI) ... solution is the first to combine Synaptics , ... expertise with proven display driver technology developed in ...
Breaking Biology News(10 mins):Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3FPC's Touch Fingerprint Sensor FPC1025 in ZTE's Smartphone Axon 2Synaptics Announces Sampling of Second Generation TDDI Solutions 2Synaptics Announces Sampling of Second Generation TDDI Solutions 3
... season almost upon us and increasing concerns about ... pickups, it is timely that researchers should turn ... Writing in a forthcoming issue of the Inderscience ... Management, researchers suggest a new approach to cutting ...
... the Commission for Environmental Cooperation (CEC) reveals that a ... environment15 percent for the United States and Canada from ... industrial facilities that are the largest generators of emissions. ... leading role of the largest waste-producing facilities stands in ...
... State University and the University of Bucharest, Romania, ... dobrogea in eastern Romania. Previously unexamined, these ancient ... 150 million years ago during the Jurassic period. ... determine various aspects of biodiversity and patterns of ...
Cached Biology News:Computer solution to delivery problem 2Toxic releases down from North American industry leaders, increasing from other facilities 2
(Date:7/30/2015)... CAMBRIDGE, Mass. , July 30, 2015 /PRNewswire/ ... software solutions for the interpretation and analysis of ... Matthew Fischer has joined the company ... Photo - http://photos.prnewswire.com/prnh/20150730/250931 ... astounding capabilities to integrate, interpret, analyze and explore ...
(Date:7/30/2015)... (PRWEB) , ... July 30, 2015 , ... ... completion of a field clinical study of its canine osteoarthritis stem cell product, ... Aratana Therapeutics (Kansas City, KS) and will be marketed in the US by ...
(Date:7/30/2015)... 30, 2015 Ascendis Pharma A/S (Nasdaq: ... its innovative TransCon technology to address significant unmet ... a six-month Phase 2 study to evaluate the ... in 53 treatment-naïve, pre-pubertal children with growth hormone ... pleased with the top-line results from our Phase ...
(Date:7/30/2015)... ... July 30, 2015 , ... ... and designed for continuous operation up to 1500 bar. The sanitary design gauge ... and preventing toxic contamination. , The Pony™ NS2006L homogenizer is an ideal solution ...
Breaking Biology Technology:GenoSpace Introduces Matthew Fischer as Vice President of Sales and Marketing 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 3Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 5Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 6Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 7GEA Announces the Pony™ NS2006L… a Self-contained, High Pressure Lab Homogenizer for Product Development Ensuring Maximum Efficiency and Safety 2
... guards came to the DHS Science and Technology Directorates ... was an emergency escape hood worthy of James Bond: a ... folding to the dimensions of a DVD case, and donnable ... be maintenance-free, filter nerve, blood, and blister agents, remove toxic ...
... Today at 5:00 p.m., CAMBRIDGE, Mass., April 21 ... the FDA has informed the,company of its opinion that ... Myozyme produced at the 2000L scale should be,classified as ... of the molecules. Currently, Genzyme has U.S.,approval to sell ...
... Antacid Delivers Faster Relief, ... Increased Convenience and Great Taste, PITTSBURGH, April 21 ... campaign,for the new TUMS(R) QuikPak(TM), the first and only instant ... part of,a larger new "Bring It On" brand strategy designed ...
Cached Biology Technology:Boys in the Hood 2Genzyme Provides Update on Myozyme(R) Manufacturing 2Genzyme Provides Update on Myozyme(R) Manufacturing 3Genzyme Provides Update on Myozyme(R) Manufacturing 4Genzyme Provides Update on Myozyme(R) Manufacturing 5New TUMS(R) QuikPak(TM) Campaign Offers Innovative Heartburn Relief with a Little Help from the Jetsons 2
... APAgene kits are designed to rapidly ... using our patented APA Technology. ... at an extraordinarily competitive price. All ... kit. The Locator Kit can be ...
Rabbit polyclonal to Yaf9 ( Abpromise for all tested applications)....
Bovine Calf Serum...
Collected from animals of U.S. origin.Collected from animals of U.S. origin. *Can be used in cell growth studies and immunoassays. *Sterility tested, * Mycoplasma tested upon request, *Endoto...
Biology Products: