Navigation Links
UCR researcher identifies mechanism malaria parasite uses to spread among red blood cells
Date:2/18/2010

ss to the genes. The transcription factors then convert these genes into protein.

While in humans such eviction of nucleosomes is specific to only some sections of the DNA strand and performed only when needed, in Plasmodium the situation is vastly different.

Le Roch's experiments in the lab show that 18 hours after Plasmodium enters a red blood cell, a huge eviction of nucleosomes occurs in the Plasmodium DNA. Gene transcription throughout the genome follows; after multiplication into up to 32 daughter cells, the newly-formed parasites are ready to exit the red blood cell and invade new ones about 18 hours later.

"We found in our experiments that histones are massively evicted everywhere in the Plasmodium genome, resulting in most of the Plasmodium genes to be transcribed at once," Le Roch said. "If we can find a candidate enzyme that can regulate this massive histone eviction, we could halt or greatly limit Plasmodium replication."

Study results appear this month in the journal Genome Research.

"Dr. Le Roch's findings document a global mechanism mediating significant changes in gene expression as the parasites transition through developmental stages in the human hosts," said Anthony A. James, a distinguished professor of microbiology & molecular genetics and molecular biology & biochemistry at UC Irvine, who was not involved in the research. "As well as being a major basic discovery, this provides a basis for probing the mechanisms for novel drug development."


'/>"/>

Contact: Iqbal Pittalwala
iqbal@ucr.edu
951-827-6050
University of California - Riverside
Source:Eurekalert  

Page: 1 2

Related biology news :

1. MDC researchers link protein tether to touch perception
2. Caltech researchers presenting at AAAS Meeting
3. Researchers develop standard of care for breast cancer survivors with lymphedema
4. U-M researchers find key interaction that controls telomeres
5. UWM researcher predicts stem cell fate with software
6. Researchers identify mechanism for Frank-Ter Haar syndrome
7. OHSU researchers discover cellular mechanism that protects against disease
8. Cameras of the future: heart researchers create revolutionary photographic technique
9. Cleveland Clinic, CWRU dental researcher finds switch that turns on the spread of cancer
10. Caltech researchers obtain first brain recordings from behaving fruit flies
11. Researchers envision high-tech applications for multiferroic crystals
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCR researcher identifies mechanism malaria parasite uses to spread among red blood cells
(Date:1/22/2015)... Inc. (NASDAQ: NXTD and NXTDW) a biometric authentication company ... of the Wocket™ smart wallet at CES 2015 in Las ... one of the "11 Hot Products at CES" in a review published ... Far" by Newseveryday.com and "The top 10 gadgets from CES 2015" by ...
(Date:1/22/2015)... 21, 2015  Analyst Report Issued by Small Cap IR. In ... that planet-wide, transactions at merchants on the leading payment cards ... of credit, debit, and prepaid cards reached 6.54 billion.  Eight ... fraudulent card usage in 2012, and credit and debit card ...
(Date:1/22/2015)... , Jan. 22, 2015 Research and Markets ... addition of the "Global Wearable Technologies Market ... Share, Overview, Trends and Forecast 2014-2020" report ... Technologies are smart devices that can be worn ...
Breaking Biology News(10 mins):CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2
... RELEASE "Snow flea antifreeze protein" could help ... Society Scientists in Illinois and Pennsylvania are ... protein that enables billions of Canadian snow fleas to ... have practical uses in extending the storage life of ...
... transplants involve the use of stem cells from another ... major concern of the potential for acute graft-versus-host disease ... by the grafted cells against the recipient, resulting in ... are no definitive markers for predicting the development of ...
... remarkable way to protect their unborn pups. Because the ... and reactivate the ovulatory cycle, pregnant mice prevent the ... Researchers from the European Molecular Biology Laboratory (EMBL) in ... ability. A surge of the chemical signal dopamine in ...
Cached Biology News:American Chemical Society's Weekly PressPac -- July 16, 2008 2American Chemical Society's Weekly PressPac -- July 16, 2008 3American Chemical Society's Weekly PressPac -- July 16, 2008 4American Chemical Society's Weekly PressPac -- July 16, 2008 5American Chemical Society's Weekly PressPac -- July 16, 2008 6American Chemical Society's Weekly PressPac -- July 16, 2008 7American Chemical Society's Weekly PressPac -- July 16, 2008 8American Chemical Society's Weekly PressPac -- July 16, 2008 9Predicting acute GVHD by gene expression could improve liver stem cell transplant outcomes 2Pregnant mice block out unwelcome admirers to protect their pups 2
(Date:1/22/2015)... Protocol Networks brings independent technology consulting ... brand-neutral, independent consultants, Protocol Networks has recently announced its ... the years, his company has attracted several clients in ... as well as others. With the success of these ...
(Date:1/22/2015)... Controlled Substance Compliance Services (CSCS), a project ... the legal requirements around using controlled substances in pharmaceutical ... As their international operations expand and become increasingly complex, ... as a result of the first phase of the ...
(Date:1/22/2015)... PALO ALTO, Calif. , Jan. 22. 2015  Varian Medical ... equipment and software, has been honored for its commitment to ... most sustainable companies. Varian is the highest ranked healthcare equipment ... ranking, announced today during the World Economic Forum at ...
(Date:12/24/2014)... , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, Inc. (NASDAQ: ... areas, announced the closing of an underwritten public offering of ... to an aggregate 3,500,000 shares of common stock, at an ... The warrants have a per share exercise price of $5.00, ...
Breaking Biology Technology:Protocol Networks Brings Independent Technology Consulting to the Constitution State 2Global Compliance Service for Controlled Substances to Expand to China 2Varian Honored Among World's 100 Most Sustainable Corporations 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3
... Consumers cutting "experimental luxuries" such as expensive spa and anti-aging treatments ... hiring someone else to pamper them, they pamper themselves by re-creating ... a new spa facial line, meets this growing demand for high ... ...
... Plastics are everywhere in our modern world, largely due ... but lightweight and easily workable. One of their most ... than break when put under stress - is also ... "plastic flow", allows many plastics to change shape to ...
... BioInformatics, LLC,( http://www.gene2drug.com ) -- the leading market ... -- announces the publication of its latest,report, "The ... the,original social media study published jointly in 2007 ... and marketing agency,-- this report explores the impact ...
Cached Biology Technology:ZhenSpa.com provides Spa Enthusiasts Affordable Alternatives for Expensive Spa Treatments 2ZhenSpa.com provides Spa Enthusiasts Affordable Alternatives for Expensive Spa Treatments 3ZhenSpa.com provides Spa Enthusiasts Affordable Alternatives for Expensive Spa Treatments 4Fast molecular rearrangements hold key to plastic's toughness 2Fast molecular rearrangements hold key to plastic's toughness 3BioInformatics, LLC Studies Effective Strategies for Scientific Publishing in a Web 2.0 World 2BioInformatics, LLC Studies Effective Strategies for Scientific Publishing in a Web 2.0 World 3
Human MFRP MAb (Clone 291218)...
Human RELT/TNFRSF19L Affinity Purified Polyclonal Ab...
... The NOS assay kit measures NOS activity ... to citrulline. This assay is simple, sensitive, ... be used with both crude and purified ... and reagents for 50 total reactions. Radiolabeled ...
SNARE associated protein snapin, clone MGC:2717...
Biology Products: