Navigation Links
UCR researcher identifies mechanism malaria parasite uses to spread among red blood cells

RIVERSIDE, Calif. Malaria remains one of the most deadly infectious diseases. Yet, how Plasmodium, the malaria parasite, regulates its infectious cycle has remained an enigma despite decades of rigorous research.

But now a research team led by a cell biologist at the University of California, Riverside has identified a mechanism by which Plasmodium intensively replicates itself in human blood to spread the disease.

"If this mechanism can be stopped," said Karine Le Roch, an assistant professor of cell biology and neuroscience, who led the research, "Plasmodium replication would cease or be severely inhibited, thus controlling the spread of malaria."

In the cells of eukaryotes, such as the unicellular Plasmodium and humans, DNA, which can be as long as two meters, is closely packed to fit into the cell's tiny nucleus. Huge complex proteins called nucleosomes facilitate this DNA compaction so that eventually the DNA is coiled in an ordered manner to form chromosomes.

Made up of histone, a kind of protein, the nucleosomes are repeating units around which the double helix of DNA gets wrapped and vast amounts of genetic information get organized.

In trying to understand how the malaria parasite multiplies in red blood cells, Le Roch's team found that in Plasmodium a kind of "histone crash" takes place a massive breakdown of histone that explains how the parasite can replicate extensively its DNA and coding gene in human red blood cells.

For cell multiplication to occur, the genes in a DNA strand need to first be transcribed and translated (converted) into protein. For this transcription to take place, however, the nucleosomes must first get evicted (removed), a process that opens up the DNA strand to give special "transcription factors" full access to the genes. The transcription factors then convert these genes into protein.

While in humans such eviction of nucleosomes is specific to only some sections of the DNA strand and performed only when needed, in Plasmodium the situation is vastly different.

Le Roch's experiments in the lab show that 18 hours after Plasmodium enters a red blood cell, a huge eviction of nucleosomes occurs in the Plasmodium DNA. Gene transcription throughout the genome follows; after multiplication into up to 32 daughter cells, the newly-formed parasites are ready to exit the red blood cell and invade new ones about 18 hours later.

"We found in our experiments that histones are massively evicted everywhere in the Plasmodium genome, resulting in most of the Plasmodium genes to be transcribed at once," Le Roch said. "If we can find a candidate enzyme that can regulate this massive histone eviction, we could halt or greatly limit Plasmodium replication."

Study results appear this month in the journal Genome Research.

"Dr. Le Roch's findings document a global mechanism mediating significant changes in gene expression as the parasites transition through developmental stages in the human hosts," said Anthony A. James, a distinguished professor of microbiology & molecular genetics and molecular biology & biochemistry at UC Irvine, who was not involved in the research. "As well as being a major basic discovery, this provides a basis for probing the mechanisms for novel drug development."


Contact: Iqbal Pittalwala
University of California - Riverside

Related biology news :

1. MDC researchers link protein tether to touch perception
2. Caltech researchers presenting at AAAS Meeting
3. Researchers develop standard of care for breast cancer survivors with lymphedema
4. U-M researchers find key interaction that controls telomeres
5. UWM researcher predicts stem cell fate with software
6. Researchers identify mechanism for Frank-Ter Haar syndrome
7. OHSU researchers discover cellular mechanism that protects against disease
8. Cameras of the future: heart researchers create revolutionary photographic technique
9. Cleveland Clinic, CWRU dental researcher finds switch that turns on the spread of cancer
10. Caltech researchers obtain first brain recordings from behaving fruit flies
11. Researchers envision high-tech applications for multiferroic crystals
Post Your Comments:
Related Image:
UCR researcher identifies mechanism malaria parasite uses to spread among red blood cells
(Date:6/2/2016)... , June 2, 2016 The Department ... has awarded the 44 million US Dollar project, for the ... Vehicle Plates including Personalization, Enrolment, and IT Infrastructure , ... in the production and implementation of Identity Management Solutions. Numerous ... however Decatur was selected for the ...
(Date:5/20/2016)... 2016  VoiceIt is excited to announce its ... By working together, VoiceIt and VoicePass will ... VoicePass take slightly different approaches to voice biometrics, ... and usability. ... partnership. "This marketing and technology partnership ...
(Date:4/28/2016)... and BANGALORE, India , April ... EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... today announced a global partnership that will provide ... to use mobile banking and payment services.      ... a key innovation area for financial services, but it also ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... , ... Parallel 6 , the leading software as a service (SaaS) ... Virtual Patient Encounter CONSULT module which enables both audio and video telemedicine communication between ... Using the CONSULT module, patients and physicians can schedule a face to face virtual ...
(Date:6/24/2016)...  Regular discussions on a range of subjects including policies, ... entities said Poloz. Speaking at a lecture to ... he pointed to the country,s inflation target, which is set ... "In certain areas there needs ... economic goals, why not sit down and address strategy together?" ...
(Date:6/23/2016)... ... June 23, 2016 , ... UAS ... the launch of their brand, UP4™ Probiotics, into Target stores nationwide. The company, ... proud to add Target to its list of well-respected retailers. This list includes ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... Plate® YM (Yeast and Mold) microbial test has received AOAC Research Institute approval ... of microbial tests introduced last year,” stated Bob Salter, Vice President of Regulatory ...
Breaking Biology Technology: