Navigation Links
UCLA study shows cell-penetrating peptides for drug delivery act like a Swiss Army Knife
Date:10/4/2011

anes, as well as with the cytoskeletons of cells," said Wong, the study's lead author. "The second part wasn't well appreciated by the field."

In addition to the membrane activity, researchers discovered that the HIV TAT peptide also creates its own binding site out of the membrane. This means the peptide can actually go through the membrane and induce the cytoskeleton directly to have an endocytotic event.

"We found that there are two channels of activity," Wong said. "Because of the peculiar sequence of HIV TAT, it's very good at being able to interact with membranes. Further, with the high-density packing of charged amino acids in the peptide, it can also interact very strongly with the cell's cytoskeleton, as well as its receptors."

In addition, the researchers noticed that small cargoes can be transferred directly, while cargoes larger than a few nanometers needed to be anchored to the membrane by the TAT peptide.

Deming, who specializes in synthetic methods, prepared the polypeptide samples for use in the experiments. Kamei, an expert in cellular trafficking, performed cell-based endocytosis experiments using inhibitor drugs and confocal microscopy to identify dominant mechanisms of endocytosis.

"This research is exciting because cell-penetrating peptides have been used in the area of drug delivery for some time," Kamei said. "Gaining any additional understanding of these delivery agents will help in future drug-carrier designs."

It is the group's hope that the new understanding gained from their study will be used to engineer new molecules that are more effective in delivering therapeutic agents.

"This collaboration was important because it combined expertise in the areas of synthesis, characterization and cellular trafficking to address a very relevant problem," Kamei said. "I definitely see more opportunity for combining these areas to tackle other problems in the growing field of biomate
'/>"/>

Contact: Wileen Wong Kromhout
wwkromhout@support.ucla.edu
310-206-0540
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Long-term study shows effect of climate change on animal diversity
2. £2 million study to reveal workings of dementia genes
3. New study looks to define evangelicals and how they affect polling
4. CU-Boulder study suggests air quality regulations miss key pollutants
5. Researchers study acoustic communication in deep-sea fish
6. Study reveals homeowner perceptions in fire-prone areas
7. Researchers study how pistachios may improve heart health
8. Study: urban black bears live fast, die young
9. New study indicates link between weight gains during pregnancy and dieting history
10. Study reveals specific gene in adolescent men with delinquent peers
11. Sweat it out: UH study examines ability of sweat patches to monitor bone loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2015)... 2015   Codonics (codonics.com), a ... image documentation solutions and Omnicell  (omnicell.com), ... solutions, is pleased to announce their state ... Label System® (SLS), an award-winning FDA class ... Omnicell Anesthesia Workstation, helps prevent medication errors, ...
(Date:5/21/2015)... May 21, 2015 According ... Market by Solutions (Hardware, Software, Services), by Applications (Surveillance ... others), by End-Users (Military & Defense & Commercial) ... Thermal Imaging Market is expected to grow from ... 2020, at a Compound Annual Growth Rate (CAGR) ...
(Date:5/19/2015)... -- Technology is rapidly advancing, outpacing enterprises, ability to secure ... and their management are soon to be rendered obsolete ... as those developed by the FIDO Alliance™. With the ... BYOD, COPE, IoT, and mobile payments, the interconnected online ... In response to the call for seamless, secure, ...
Breaking Biology News(10 mins):Codonics and Omnicell Expand Partnership 2Codonics and Omnicell Expand Partnership 3Codonics and Omnicell Expand Partnership 4Thermal Imaging Market Worth $9,998.9 Million by 2020 2Thermal Imaging Market Worth $9,998.9 Million by 2020 3Thermal Imaging Market Worth $9,998.9 Million by 2020 4HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 3
... of DNA modification in lung cancer, a team of international ... mechanism. They say that "silencing" of a single gene in ... in cells, contributing to cancer development and progression. In ... a journal of the American Association for Cancer Research, they ...
... C or E or a combination of the supplements had ... take the supplements, according to data from a randomized controlled ... Journal of the National Cancer Institute. Epidemiological studies ... and vegetables, and thus antioxidants, may have a lower risk ...
... (NTU) undergraduate Liu Shiyu has the honour of becoming ... prize in a global competition that pitted engineering students ... the competition organised by the Institution of Engineering and ... from NTU,s School of Mechanical & Aerospace Engineering beat ...
Cached Biology News:In lung cancer, silencing one crucial gene disrupts normal functioning of genome 2In lung cancer, silencing one crucial gene disrupts normal functioning of genome 3Vitamins C and E and beta carotene again fail to reduce cancer risk in randomized controlled trial 2NTU undergrad is first Singapore champion of an internationally acclaimed engineering competition 2NTU undergrad is first Singapore champion of an internationally acclaimed engineering competition 3
(Date:6/1/2015)... - BIOREM Inc. (TSX-V: BRM) ("Biorem" or "the Company") today announced results ... 2015 first quarter financial statements and MD&A have been filed on ... March 31,(in CDN$,000 except per share data) , 2015 ... Gross profit , 1,531 , 329 Ebitda* , ... 528 , (531) Basic earnings (loss) per share ...
(Date:6/1/2015)... DUBLIN , June 1, 2015 ... has announced the addition of the "Global ... their offering.        ... Industry Report 2014 is a professional and in-depth ... industry. , ,The report provides a basic overview ...
(Date:6/1/2015)... Regis Technologies, Inc. is a ... stationary phases (CSPs) for analytical and preparative chromatography ... presenting solutions for new clients, Regis implemented a ... addition to its core expertise in chiral chromatography ... tackle projects for the scale clients need–from milligram ...
(Date:6/1/2015)... , June 1, 2015  Fennec Pharmaceuticals, Inc. ... positive interim results from a poster presented today ... label randomised phase III trial of the efficacy ... patients receiving cisplatin (Cis) monotherapy for standard risk ... American Society of Clinical Oncology (ASCO) 2015 Annual ...
Breaking Biology Technology:Biorem Reports Increased Revenues and Earnings for First Quarter 2Biorem Reports Increased Revenues and Earnings for First Quarter 3Global PDT Machine Industry Report 2014 2Regis Technologies Offers Chiral Chromatography Service 2Regis Technologies Offers Chiral Chromatography Service 3Fennec Announces Presentation Of Positive Interim Sodium Thiosulfate Phase III Safety Data At The 2015 ASCO Annual Meeting 2Fennec Announces Presentation Of Positive Interim Sodium Thiosulfate Phase III Safety Data At The 2015 ASCO Annual Meeting 3Fennec Announces Presentation Of Positive Interim Sodium Thiosulfate Phase III Safety Data At The 2015 ASCO Annual Meeting 4
... Corp. (Nasdaq: BSTC ), a biopharmaceutical company developing ... Company will host a conference call and live audio ... 2009 to discuss its third quarter 2009 financial results ... call, please dial 800-860-2442 (domestic) or 412-858-4600 (international). The ...
... Oct. 30 /PRNewswire-Asia-FirstCall/ -- BMP Sunstone,Corporation (Nasdaq: BJGP ) ("BMP Sunstone" ... , -- Oppenheimer 20th Annual Healthcare Conference, to be ... Waldorf=Astoria hotel in New York. Management is scheduled, ... and meet with, institutional investors throughout ...
... Sandia researchers have developed a process that can ... Researchers currently use all types of processes to ... small devices," says Sandia materials scientist Jim Martin "people ... to initiate mixing, but these approaches don,t work well." ...
Cached Biology Technology:BioSpecifics Technologies Corp. to Host Conference Call to Report Third Quarter 2009 Financial Results on November 5, 2009 2BMP Sunstone Announces November Investor Conference Participation 2Magnetic mixing creates quite a stir 2Magnetic mixing creates quite a stir 3
SHEEP ANTI HUMAN ESTRONE...
Request Info...
... cell culture systems provide an ... cells for staining and imaging. ... gaskets preassembled with standard optical-quality ... The entire system is provided ...
... magnetic separator for 96-well microplates ... conjunction with the Captivate ferrofluid ... other magnetic particles and is ... Cell Biology Cell Separation Captivate ...
Biology Products: