Navigation Links
UCLA study identifies genetic variation linked to lupus in Asian men
Date:8/23/2010

Genes reside along long chains of DNA called chromosomes. UCLA researchers have found that a variation in a gene on the sex chromosome X may enhance an immune response that leads to lupus in men.

Systemic lupus erythematosus (SLE) is an autoimmune disease that predominantly affects women. Interestingly, researchers found that although the variation occurred in a gene on the X, or female, chromosome, its influence was stronger in men than in women. Humans hold two sex chromosomes men have an X and Y, while women have two Xs. Previous studies have shown that genetic variations on the X chromosome contribute to the development of lupus.

In this study, researchers found that certain common variations of DNA sequences within a specific X-linked gene triggered a stronger response in the immune system, increasing the risk of developing lupus, especially in men.

This study was part of an international effort to study the genetics of lupus in broader ethnic groups. Researchers genotyped 9,274 Eastern Asians individuals, including those with lupus and healthy controls. The stronger genetic effects were seen in men, compared with women, and especially in Chinese and Japanese men. Further study will look at other ethnicities.

Researchers say the finding will lead to greater understanding of the development of lupus and to further exploration of the sex-specific genetic contributions of the disease, which could result in more targeted therapies.


'/>"/>

Contact: Rachel Champeau
rchampeau@mednet.ucla.edu
310-794-2270
University of California - Los Angeles
Source:Eurekalert

Page: 1

Related biology news :

1. Study offers historic buildings protection from climate change
2. CEAP study examines nitrogen, copper levels in Bay watershed
3. CCNY biologists study rainforest host-plant associations
4. Study explains why Alzheimers drug is both safe and effective
5. Study shows genes role in developing and maintaining cells key for a lifetime of memories
6. Grant to study effects of oil and dispersants on Louisiana salt marsh ecosystem
7. Blood stem cell, leukemia link illuminated in UCSF-led study
8. Landmark dental school study uses genetic test to help predict gum disease
9. Illinois researchers use pyrosequencing to study canine intestinal bacteria
10. Study to examine rising sea levels impact on estuaries, coastal communities
11. Tinnitus study looks for cure to ringing in the ears
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2017)... , April 18, 2017  Socionext Inc., a global expert in ... media edge server, the M820, which features the company,s hybrid codec ... provided by Tera Probe, Inc., will be showcased during the upcoming ... NAB show at the Las Vegas Convention ... Click ...
(Date:4/13/2017)... MONICA, Calif. , April 13, 2017 ... New York will feature emerging and evolving ... Summits. Both Innovation Summits will run alongside the expo ... of speaker sessions, panels and demonstrations focused on trending ... coast,s largest advanced design and manufacturing event will take ...
(Date:4/11/2017)... Fla. , April 11, 2017 ... and secure authentication solutions, today announced that it ... Intelligence Advanced Research Projects Activity (IARPA) to develop ... Thor program. "Innovation has been a ... IARPA,s Thor program will allow us to innovate ...
Breaking Biology News(10 mins):
(Date:8/14/2017)... ... August 14, 2017 , ... Every ... Key researchers in the antibody community have recently come together to address this ... in the laboratory. , The team at Thermo Fisher Scientific ...
(Date:8/11/2017)... ROCKVILLE, Md. , Aug. 11, 2017 ... in a New York Times article regarding ... 9.2 billion, according to Kalorama Information.  The ... an App for That"  used information ... Remote Patient Monitoring & Telemedicine Market  (Sleep, ...
(Date:8/11/2017)... ... 2017 , ... “There is an increasing consumer call for ... ingredients,” said Matt Hundt, President of Third Wave Bioactives. “Combining the strong discovery ... of Biorigin will allow us to bring truly novel fermented ingredient technologies to ...
(Date:8/10/2017)... ... 09, 2017 , ... The era of using extracellular vesicles ... team at Capricor Therapeutics, Inc. utilized a cardiosphere-derived stem-like cell culturing process to ... Travis Antes, head of analytical development at Capricor Therapeutics Inc., will be the ...
Breaking Biology Technology: