Navigation Links
UCLA scientists receive $2 million grant to improve quality of donor livers for transplant

A team of scientists from the UCLA Departments of Surgery and Pathology and Laboratory Medicine have been awarded a three-year, $2 million grant from the W.M. Keck Foundation to fund research aimed at increasing the quality of donor livers.

Dr. Jerzy W. Kupiec-Weglinski, principal investigator for the project and director of the Dumont-UCLA Transplantation Research Center, said he hopes his research will address the decreasing quality of donor organs and a widening disparity between the increasing numbers of potential transplant recipients and inadequate donor organ supply.

The major factor contributing to the decrease in organ quality is the aging donor population, and conditions associated with aging that make the liver less desirable. These "suboptimal" organs are more susceptible to the harmful effects of ischemia/reperfusion injury (IRI), innate immune-mediated tissue damage that occurs during organ harvesting from cadaver sources and during periods of extended cold preservation. Even if successfully transplanted, these marginal livers experience a high incidence of early dysfunction and late rejection.

Kupiec-Weglinski's project seeks to upend the current dogma treating transplant patients with cocktails of relatively non-specific immunosuppressive agents to prevent organ rejection.

He and his team hope to rejuvenate donor livers and improve their quality before transplantation by advancing novel concepts of selectively targeting local innate immune activation, a signature of the hepatic ischemia-reperfusion syndrome, and by enhancing local mechanisms that promote survival and regeneration of hepatocytes, which make up 70-85% of the liver's cytoplasmic mass. They also hope to find ways to boost inherent mechanisms that promote homeostasis in IRI-stressed liver tissue.

To facilitate such a paradigm-shifting objective, the team will employ a step-wise, experimental plan, starting with laboratory models using cultured cells and then moving on to animal models and, ultimately, human liver tissue. Their goal is to validate novel molecular targets that predict donor liver quality and transplant survival.

The project is based on extensive preliminary data and promising early findings, Kupiec-Weglinski said.

"Our project has the potential to result in a significant paradigm shift, opening up the possibility of developing new ways to improve donor organ quality and allow use of otherwise unusable and discarded marginal livers," he said. "If we succeed, it will have a major and direct impact on organ transplantation worldwide."


Contact: Kim Irwin
University of California - Los Angeles Health Sciences

Related biology news :

1. Cancer scientists discover novel way gene controls stem cell self-renewal
2. UK & USA scientists collaborate to design crops of the future
3. Scientists uncover the secret life of frozen soils
4. Tufts scientists develop new early warning system for cholera epidemics
5. Cattle can be a source of MRSA in people, scientists find
6. LLNL scientists make new discoveries in the transmission of viruses between animals and humans
7. Scientists develop method that ensures safe research on deadly flu viruses
8. Neuroscientists identify protein linked to Alzheimers-like afflictions
9. Illinois scientists put cancer-fighting power back into frozen broccoli
10. Scientists learn how soy foods protect against colon cancer
11. Wistar scientists decipher structure of NatA, an enzyme complex that modifies most human proteins
Post Your Comments:
(Date:10/8/2015)... Oktober 2015 Die Track Group, ... des Bereiches Tracking, hat heute bekannt gegeben, ... Virginias (Department of Corrections – DOC) unterzeichnet ... alle Strafen geliefert werden, die der Behörde ... für den Amerikanischen Kontinent der Track Group. ...
(Date:10/6/2015)... 2015 Track Group, Inc. (OTCQX: TRCK), a ... signed a contract with the Virginia Department of Corrections ... of sentences under the Department,s oversight. Derek ... contract with the Virginia DOC will expand our footprint ... our position as a trusted leader in offender electronic ...
(Date:10/1/2015)... Oct. 1, 2015  Biometrics includes diverse set ... body characteristics, such as fingerprints, eye retinas, facial ... of biometrics technology has been constantly increasing in ... five years. In addition to the most prominent ... recognition, other means of biometric authentication are rapidly ...
Breaking Biology News(10 mins):
(Date:10/13/2015)... , ... October 13, 2015 , ... ... recombinant antibodies, today announced that it has received a Phase I Small Business ... by the National Institute of General Medical Sciences (NIGMS), will fund the development ...
(Date:10/13/2015)... , October 13, 2015 ... and development company, has entered into a strategic relationship ... and Paris, France ... --> --> This collaborative arrangement gives ... respected scientific advisory team as well as long established ...
(Date:10/13/2015)... , Oct. 13, 2015  According to Kalorama ... will reach $102 billion by the end of ... the health industry, as it is estimated that ... of laboratory tests. In addition to diagnosing patients, ... evaluate disease progression, monitor drug treatment and conditions, ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... of automation systems, material handling solutions and components, is opening its latest Parker ... State Street, the facility is Exotic’s second major expansion in Metropolitan Detroit in ...
Breaking Biology Technology: