Navigation Links
UCLA scientists receive $2 million grant to improve quality of donor livers for transplant
Date:8/27/2013

A team of scientists from the UCLA Departments of Surgery and Pathology and Laboratory Medicine have been awarded a three-year, $2 million grant from the W.M. Keck Foundation to fund research aimed at increasing the quality of donor livers.

Dr. Jerzy W. Kupiec-Weglinski, principal investigator for the project and director of the Dumont-UCLA Transplantation Research Center, said he hopes his research will address the decreasing quality of donor organs and a widening disparity between the increasing numbers of potential transplant recipients and inadequate donor organ supply.

The major factor contributing to the decrease in organ quality is the aging donor population, and conditions associated with aging that make the liver less desirable. These "suboptimal" organs are more susceptible to the harmful effects of ischemia/reperfusion injury (IRI), innate immune-mediated tissue damage that occurs during organ harvesting from cadaver sources and during periods of extended cold preservation. Even if successfully transplanted, these marginal livers experience a high incidence of early dysfunction and late rejection.

Kupiec-Weglinski's project seeks to upend the current dogma treating transplant patients with cocktails of relatively non-specific immunosuppressive agents to prevent organ rejection.

He and his team hope to rejuvenate donor livers and improve their quality before transplantation by advancing novel concepts of selectively targeting local innate immune activation, a signature of the hepatic ischemia-reperfusion syndrome, and by enhancing local mechanisms that promote survival and regeneration of hepatocytes, which make up 70-85% of the liver's cytoplasmic mass. They also hope to find ways to boost inherent mechanisms that promote homeostasis in IRI-stressed liver tissue.

To facilitate such a paradigm-shifting objective, the team will employ a step-wise, experimental plan, starting with laboratory models using cu
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-794-2262
University of California - Los Angeles Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Cancer scientists discover novel way gene controls stem cell self-renewal
2. UK & USA scientists collaborate to design crops of the future
3. Scientists uncover the secret life of frozen soils
4. Tufts scientists develop new early warning system for cholera epidemics
5. Cattle can be a source of MRSA in people, scientists find
6. LLNL scientists make new discoveries in the transmission of viruses between animals and humans
7. Scientists develop method that ensures safe research on deadly flu viruses
8. Neuroscientists identify protein linked to Alzheimers-like afflictions
9. Illinois scientists put cancer-fighting power back into frozen broccoli
10. Scientists learn how soy foods protect against colon cancer
11. Wistar scientists decipher structure of NatA, an enzyme complex that modifies most human proteins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... RESEARCH TRIANGLE PARK, N.C. , Feb. 5, 2015 ... as a specialist logistics company and has launched a ... industry,s only Clinical Logistics Organization (CLO).  The new campaign ... with emphasis on patient, protocol and shipments. ... Patient First , aligns Marken,s priorities with its ...
(Date:2/5/2015)... NXT-ID, Inc. (NASDAQ: NXTD ... company focused on the growing mobile commerce market, announces ... CEO Conference on January 29 th at 10:30 ... CEO of NXT-ID will present and host a live ... wallet and its full suite of biometric technologies. Investors ...
(Date:1/22/2015)... ("Company") (BM&FBOVESPA: VLID3 ON), is pleased to inform its shareholders ... Washington,s Department of Licensing, in the United States, awarded ... for driver,s licenses and identification cards to its subsidiary, Valid ... start in January 2015, with enrollment and card production starting ...
Breaking Biology News(10 mins):Marken Launches New Patient-Centric Campaign 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 3Valid USA Signs Contract For Washington Driver's License Issuance 2
... team has discovered an influenza detector gene that could ... Katharine Magor, a U of A associate professor ... ducks to live, unharmed, as the host of influenza. ... geneI, or RIG-I, enables a duck,s immune system to ...
... Md. -- Amphibiansfrogs, toads, salamanders, and newtsare disappearing worldwide, ... to be stable. This region is home to the ... 70 species reside here), and scientists want to understand ... In research published in the March 29, 2010 issue ...
... the UK and USA announce plans to promote scientific ... The Biotechnology and Biological Sciences Research Council (BBSRC) ... to hold an intensive week long facilitated workshop ... to bring together leading researchers across all disciplines to ...
Cached Biology News:Young salamanders' movement over land helps stabilize populations 2Young salamanders' movement over land helps stabilize populations 3BBSRC and NSF join together to promote new ideas to enhance photosynthesis 2
(Date:2/26/2015)... According to a new market report ... Transgenic Crops (Corn, Soybean, Cotton and Others), Synthetic Biology-Enabled ... Growth, Trends and Forecast, 2013 – 2019,”the global agricultural ... 2012 and is expected to reach USD 28,694.1 million ... 2013 to 2019. , Demand for food production ...
(Date:2/26/2015)... 2015 Regis Technologies announced new ... oncology drug substances. , Regis Technologies is proud to ... Potent Compound Suite (PCS) for 2015. , Regis is ... cGMP facility in Morton Grove, Illinois. The PCS addition ... compounds up to about one kilogram per batch. ...
(Date:2/26/2015)... , Feb. 26, 2015 Tauriga Sciences, ... sciences company with interests in the natural wellness sector ... announced today that its products will be featured at ... Capital Partners, 27 th Annual Growth Stock Conference ... located at 1 Ritz Carlton Drive, Dana ...
(Date:2/26/2015)...   Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX ... Cowen 35 th Annual Health Care Conference on Tuesday, ... Boston .  Lexicon management will provide an overview of ... of the presentation will be available through Lexicon,s website at ... be available at www.lexpharma.com until April 3, 2015. ...
Breaking Biology Technology:Global Agricultural Biotechnology Market is Expected to Reach USD 28,694.1 Million in 2019 : Transparency Market Research 2Global Agricultural Biotechnology Market is Expected to Reach USD 28,694.1 Million in 2019 : Transparency Market Research 3Regis Extends cGMP Services to Oncology Market 2SEC Compliance Featuring Products From Tauriga Sciences, Inc. at ROTH Capital Conference 2SEC Compliance Featuring Products From Tauriga Sciences, Inc. at ROTH Capital Conference 3SEC Compliance Featuring Products From Tauriga Sciences, Inc. at ROTH Capital Conference 4Lexicon To Present At The Cowen 35th Annual Health Care Conference 2
... intended to support renewed strategic transaction,effort, SOUTH ... Bulletin Board: VXGN), a biopharmaceutical company, today announced,the ... of Directors, and the,resignations of three of its ... Stefano, J.D., a principal with the law firm ...
... Health Agency,s Community Health Surveillance System Detects ... ... the course of two hours,on a recent Friday, 20 people arrived, ... Each separately complained of various,gastrointestinal symptoms, including nausea and diarrhea., ...
... Corporation announced today the,commercial release of its Extended ... This technology breaks through classical depth of field,limitations ... of the ImageStream system and enabling new applications,including ... EDF option can be installed at time of ...
Cached Biology Technology:VaxGen Restructures Board of Directors 2E. coli Outbreak in New Jersey? 2E. coli Outbreak in New Jersey? 3Amnis Announces Release of Its Extended Depth of Field Option for The ImageStream(R) System 2
Rabbit polyclonal to Bag5 ( Abpromise for all tested applications). entrezGeneID: 9529 SwissProtID: Q9UL15...
Rabbit polyclonal to VEZT ( Abpromise for all tested applications). Antigen: Full length human VEZT conjugated to GST Entrez Gene ID: 55591 Swiss Protein ID: Q9HBM0...
Phospho-4E-BP1 (Thr37/46) (236B4) Rabbit mAb Shipping Temperature: Cold Storage Temperature: -20C...
Goat polyclonal to FBXO2 ( Abpromise for all tested applications). entrezGeneID: 26232 SwissProtID: Q9UK22...
Biology Products: