Navigation Links
UCLA scientists receive $2 million grant to improve quality of donor livers for transplant
Date:8/27/2013

A team of scientists from the UCLA Departments of Surgery and Pathology and Laboratory Medicine have been awarded a three-year, $2 million grant from the W.M. Keck Foundation to fund research aimed at increasing the quality of donor livers.

Dr. Jerzy W. Kupiec-Weglinski, principal investigator for the project and director of the Dumont-UCLA Transplantation Research Center, said he hopes his research will address the decreasing quality of donor organs and a widening disparity between the increasing numbers of potential transplant recipients and inadequate donor organ supply.

The major factor contributing to the decrease in organ quality is the aging donor population, and conditions associated with aging that make the liver less desirable. These "suboptimal" organs are more susceptible to the harmful effects of ischemia/reperfusion injury (IRI), innate immune-mediated tissue damage that occurs during organ harvesting from cadaver sources and during periods of extended cold preservation. Even if successfully transplanted, these marginal livers experience a high incidence of early dysfunction and late rejection.

Kupiec-Weglinski's project seeks to upend the current dogma treating transplant patients with cocktails of relatively non-specific immunosuppressive agents to prevent organ rejection.

He and his team hope to rejuvenate donor livers and improve their quality before transplantation by advancing novel concepts of selectively targeting local innate immune activation, a signature of the hepatic ischemia-reperfusion syndrome, and by enhancing local mechanisms that promote survival and regeneration of hepatocytes, which make up 70-85% of the liver's cytoplasmic mass. They also hope to find ways to boost inherent mechanisms that promote homeostasis in IRI-stressed liver tissue.

To facilitate such a paradigm-shifting objective, the team will employ a step-wise, experimental plan, starting with laboratory models using cultured cells and then moving on to animal models and, ultimately, human liver tissue. Their goal is to validate novel molecular targets that predict donor liver quality and transplant survival.

The project is based on extensive preliminary data and promising early findings, Kupiec-Weglinski said.

"Our project has the potential to result in a significant paradigm shift, opening up the possibility of developing new ways to improve donor organ quality and allow use of otherwise unusable and discarded marginal livers," he said. "If we succeed, it will have a major and direct impact on organ transplantation worldwide."


'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-794-2262
University of California - Los Angeles Health Sciences
Source:Eurekalert

Related biology news :

1. Cancer scientists discover novel way gene controls stem cell self-renewal
2. UK & USA scientists collaborate to design crops of the future
3. Scientists uncover the secret life of frozen soils
4. Tufts scientists develop new early warning system for cholera epidemics
5. Cattle can be a source of MRSA in people, scientists find
6. LLNL scientists make new discoveries in the transmission of viruses between animals and humans
7. Scientists develop method that ensures safe research on deadly flu viruses
8. Neuroscientists identify protein linked to Alzheimers-like afflictions
9. Illinois scientists put cancer-fighting power back into frozen broccoli
10. Scientists learn how soy foods protect against colon cancer
11. Wistar scientists decipher structure of NatA, an enzyme complex that modifies most human proteins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/4/2017)... NEW YORK , April 4, 2017   ... solutions, today announced that the United States Patent and ... The patent broadly covers the linking of an iris ... the same transaction) and represents the company,s 45 th ... our latest patent is very timely given the multi-modal ...
(Date:3/30/2017)... -- On April 6-7, 2017, Sequencing.com will host the world,s ... at Microsoft,s headquarters in Redmond, Washington ... health and wellness apps that provide a unique, personalized ... is the first hackathon for personal genomics and the ... the genomics, tech and health industries are sending teams ...
(Date:3/30/2017)... -- Trends, opportunities and forecast in this market to ... AFIS, iris recognition, facial recognition, hand geometry, vein recognition, ... industry (government and law enforcement, commercial and retail, health ... and by region ( North America , ... , and the Rest of the World) ...
Breaking Biology News(10 mins):
(Date:7/17/2017)... Ca (PRWEB) , ... July 17, 2017 , ... ... and are characterized by a wide range of overlapping clinical features. The advancement ... discovery in the field of NDD research and testing. , However, designing ...
(Date:7/17/2017)... ... July 17, 2017 , ... Co-Diagnostics, Inc. (NASDAQ: CODX) (“Co-Diagnostics” ... to manufacture and sell reagents used for diagnostic tests, has completed its initial ... Sandy, Utah, Co-Diagnostics’ intellectual property and technologies are protected by five granted or ...
(Date:7/16/2017)... ... July 16, 2017 , ... OHAUS Corporation, a ... launch of its new line of Rocking and Waving Shakers today. , Five ... (both analog and digital) for laboratory applications in a variety of environmental conditions. ...
(Date:7/15/2017)... (PRWEB) , ... July 15, 2017 , ... Cuvette ... 5 years. During this time, the people at FFS have learned that their ... customers, engineers at FFS are able to launch new products to meet the changing ...
Breaking Biology Technology: