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UCLA scientists map all mammalian gene interactions
Date:8/9/2010

etworks involved in promoting disease to the criminal world.

"The most well-connected gene represents someone powerful, like Al Capone, surrounded by his gang of mobsters. If we don't have a drug to target this main gene, there may be an existing drug that will effectively knock out a second-in-command, launching a flank attack that would cripple the primary gene's actions."

The findings, the researchers said, will help researchers in the field.

"The UCLA interaction map is a significant one that will help broaden the understanding of the working relationships between genes," said Tara C. Matise, an associate professor in the department of genetics at Rutgers University and director of the Laboratory of Computational Genetics, who was not part of the study. "The more information we acquire about genetic interactions, the more effective scientists can be in developing bench-to-bedside research."

Now that the researchers have mapped these interactions, the next step is to conduct biological experiments to further understand these interactions and how the genes work together.


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Contact: Rachel Champeau
rchampeau@mednet.ucla.edu
310-794-2270
University of California - Los Angeles
Source:Eurekalert  

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