Navigation Links
UCLA scientists identify how major biological sensor in the body works
Date:6/6/2011

A biological sensor is a critical part of a human cell's control system that is able to trigger a number of cell activities. A type of sensor known as the "gating ring" can open a channel that allows a flow of potassium ions through the cell's wall or membrane similar to the way a subway turnstile allows people into a station. This flow of ions, in turn, is involved in the regulation of crucial bodily activities like blood pressure, insulin secretion and brain signaling.

But the biophysical functioning of the gating ring sensor has not been clearly understood. Now, UCLA researchers have uncovered for the first time the sensor's molecular mechanism, shedding new light on the complexity of cells' control systems.

The findings, published in the June 10 issue of the Journal of Biological Chemistry and featured as a "Paper of the Week," could lead to the development of specific therapies against diseases such as hypertension and genetic epilepsy.

Just as a smoke detector senses its environment and responds by emitting a sound signal, cells control their intracellular environment through molecular sensors that assess changes and trigger a response.

In this case, when calcium ions bind to the gating ring which constitutes the intracellular part of an ionic channel known as the BK channel the cell responds by allowing the flow of potassium ions across the cell membrane, with a wide range of consequences for the body.

BK channels are present in most cells in the body and regulate fundamental biological processes such as blood pressure, electrical signaling in the brain and nervous system, inner ear hair-tuning that impacts hearing, muscle contractions in the bladder, and insulin secretion from the pancreas, to name a few.

The UCLA researchers were able to identify for the first time how the gating ring is activated and how it rearranges itself to open the gateway that the ions flow through. Us
'/>"/>

Contact: Rachel Champeau
rchampeau@mednet.ucla.edu
310-794-2270
University of California - Los Angeles Health Sciences
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Stanford climate scientists forecast permanently hotter summers
2. Scientists uncover role for cell scaffold in tumor formation
3. Scientists use super microscope to pinpoint body’s immunity switch
4. Scripps Research scientists find way to block stress-related cell death
5. Scripps Research scientists find key mechanism in transition to alcohol dependence
6. Harvard scientists see the early cellular cause of dry eye disease for the first time
7. Scientists crack the spiders web code
8. Scientists discover fossil of giant ancient sea predator
9. Scientists discover the largest assembly of whale sharks ever recorded
10. Syracuse University scientists discover new hitch to link nerve cell motors to their cargo
11. Scientists list top 10 new species
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCLA scientists identify how major biological sensor in the body works
(Date:12/19/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ) ... 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire ... http://photos.prnewswire.com/prnh/20130307/600769 ... 2012, Apple introduced the fingerprint reading feature with ... device of Apple incorporating such a feature, called ...
(Date:12/17/2014)... FORT BELVOIR, Va. , Dec. 15, 2014 ... its efforts to make it easier to detect ... supply chain. Today the agency started ... marking. The capability will validate the authenticity of ... supply chain. The new quality control measures will ...
(Date:12/15/2014)... , Dec. 12, 2014 Research and ... the addition of the "Global Facial Recognition ... http://photos.prnewswire.com/prnh/20130307/600769 ... identification of individuals. Facial recognition system measures the ... nose, jaw edges, mouth, and the distance between ...
Breaking Biology News(10 mins):iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3
... menthol cigarettes more addictive? Smokers of menthol cigarettes ... smoking, and are more likely to become addicted. The traditional ... the harsh taste of tobacco and thus entices people to ... University in the USA here review recent scientific findings and ...
... ability to pay attention to relevant information while ignoring ... to focus and filter out "noise," we could not ... attention in the brain, the cellular mechanisms responsible for ... now., In a study appearing in the journal ...
... Ky. Some of the top scientists in the ... Medicine members, will make presentations at a University of ... "Neuroscience Symposium: Anatomical and Functional Modularity of the Cerebral ... Hospital Conference Center, 200 Abraham Flexner Way. Admission is ...
Cached Biology News:Frontiers news briefs: July 23 2Frontiers news briefs: July 23 3Frontiers news briefs: July 23 4Neuroscience symposium bringing top scientists to Louisville, Aug. 1-2 2
(Date:12/24/2014)... , Dec. 23, 2014 Vermillion, Inc. ... on gynecologic disease, announced today that investors including ... Birchview Fund LLC and several Vermillion directors have ... shares of Vermillion,s common stock and warrants to ... a private placement.  Under the ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 The ... global leader of technical training across the life sciences ... Data Management (SCDM) to provide the organization's members ... programs —providing access to the more than 350 sessions ... members with 10% off when registering for a ...
(Date:12/22/2014)... 22, 2014  ( www.competitivehealth.com ) — Competitive Health ... bill review and advocacy service, has signed an agreement ... Savings discount health services marketplace. 63% of ... than they expected to pay. As part of an ... WellCard Savings is pleased to offer medical bill review ...
(Date:12/19/2014)... Lawrence, MA (PRWEB) December 19, 2014 ... flow MRLAFMQ test for the Detection of Aflatoxin M1 ... test to receive independent third party validation. The peer ... Science Unit of the Institute for Agricultural and Fisheries ... Francis Group. , Aflatoxin B1, the most toxic ...
Breaking Biology Technology:Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2
... achieves four-fold revenue increase as broad corporate changes are ... ... Advance Nanotech, Inc. (OTC,Bulletin Board: AVNA) today reported financial results ... first, full fiscal,period since the Company refocused its business model from ...
... May 18 /Xinhua-PRnewswire-Firstcall/ -- Specialist,Pharmaceutical Company Pharmaxis ... it has received national approval to market ... measuring airway hyperresponsiveness and has,been approved in ... (MRP). The necessary national approvals that follow ...
... term patches" in health care ... ... price negotiation and physician reimbursement as a means to,reduce health care ... for truly reforming health care, former Centers for,Medicare and Medicaid Services ...
Cached Biology Technology:Advance Nanotech Reports First Quarter 2008 Financial Results 2Advance Nanotech Reports First Quarter 2008 Financial Results 3Advance Nanotech Reports First Quarter 2008 Financial Results 4Advance Nanotech Reports First Quarter 2008 Financial Results 5Advance Nanotech Reports First Quarter 2008 Financial Results 6Advance Nanotech Reports First Quarter 2008 Financial Results 7Advance Nanotech Reports First Quarter 2008 Financial Results 8Advance Nanotech Reports First Quarter 2008 Financial Results 9Advance Nanotech Reports First Quarter 2008 Financial Results 10Pharmaxis' Aridol Authorised for Sale in Germany 2Pharmaxis' Aridol Authorised for Sale in Germany 3Former CMS Administrator: "'Blunt Instrument' Policies an Increasingly Bad Fit in Era of Personalized Health Care" 2Former CMS Administrator: "'Blunt Instrument' Policies an Increasingly Bad Fit in Era of Personalized Health Care" 3
... X-Gal ,MOLECULAR BIOLOGY GRADE ,5-Bromo-4-chloro-3-indoxyl-beta-D-galactopyranoside ... Br Cl N O 6 ... (HPLC) ,Solution: Clear (2% in DMF) ... pUC and M13 ,Elemental Analysis: Agrees ...
...
... MW: 34.2kDa Formulation: 10mM HEPES, pH ... dithiothreitiol with 50% glycerol Properites: For ... Certificate of Analysis for individual lots ... followed by gel filtration and Mono-S ...
Antibody Purification Specificity: Antibody Purification ...
Biology Products: