Navigation Links
UCLA scientists identify how major biological sensor in the body works
Date:6/6/2011

A biological sensor is a critical part of a human cell's control system that is able to trigger a number of cell activities. A type of sensor known as the "gating ring" can open a channel that allows a flow of potassium ions through the cell's wall or membrane similar to the way a subway turnstile allows people into a station. This flow of ions, in turn, is involved in the regulation of crucial bodily activities like blood pressure, insulin secretion and brain signaling.

But the biophysical functioning of the gating ring sensor has not been clearly understood. Now, UCLA researchers have uncovered for the first time the sensor's molecular mechanism, shedding new light on the complexity of cells' control systems.

The findings, published in the June 10 issue of the Journal of Biological Chemistry and featured as a "Paper of the Week," could lead to the development of specific therapies against diseases such as hypertension and genetic epilepsy.

Just as a smoke detector senses its environment and responds by emitting a sound signal, cells control their intracellular environment through molecular sensors that assess changes and trigger a response.

In this case, when calcium ions bind to the gating ring which constitutes the intracellular part of an ionic channel known as the BK channel the cell responds by allowing the flow of potassium ions across the cell membrane, with a wide range of consequences for the body.

BK channels are present in most cells in the body and regulate fundamental biological processes such as blood pressure, electrical signaling in the brain and nervous system, inner ear hair-tuning that impacts hearing, muscle contractions in the bladder, and insulin secretion from the pancreas, to name a few.

The UCLA researchers were able to identify for the first time how the gating ring is activated and how it rearranges itself to open the gateway that the ions flow through. Us
'/>"/>

Contact: Rachel Champeau
rchampeau@mednet.ucla.edu
310-794-2270
University of California - Los Angeles Health Sciences
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Stanford climate scientists forecast permanently hotter summers
2. Scientists uncover role for cell scaffold in tumor formation
3. Scientists use super microscope to pinpoint body’s immunity switch
4. Scripps Research scientists find way to block stress-related cell death
5. Scripps Research scientists find key mechanism in transition to alcohol dependence
6. Harvard scientists see the early cellular cause of dry eye disease for the first time
7. Scientists crack the spiders web code
8. Scientists discover fossil of giant ancient sea predator
9. Scientists discover the largest assembly of whale sharks ever recorded
10. Syracuse University scientists discover new hitch to link nerve cell motors to their cargo
11. Scientists list top 10 new species
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCLA scientists identify how major biological sensor in the body works
(Date:6/16/2015)... Fingerprint Cards (FPC) raises the revenue guidance for ... at least 340 MSEK to that it will amount to ... growth and orders received the revenue guidance for 2015 is ... will exceed 1,500 MSEK to an updated guidance that revenue ... Due to receipt of orders of touch fingerprint sensors with ...
(Date:6/12/2015)... June 12, 2015  Securus Technologies, a leading ... for public safety, investigation, corrections and monitoring, announced ... to electronically capture, analyze and identify participants of ... methods. This system can: ... enrollment and subsequent sign-on process is actually the ...
(Date:6/9/2015)... , June 09, 2015 Research ... addition of the "Gesture Recognition & Touchless ... (Consumer Electronics, Automotive, & Others), Product (Biometric & ... to 2020" report to their offering. ... market is expected to reach $ 23.55 Billion ...
Breaking Biology News(10 mins):Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 2Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 3Securus Announces Patent Issued for Authorized Presence Verification During Video Visitation 2Global Gesture Recognition & Touchless Sensing (Technology, Application & Products) Market 2015-2020 2
... could release at least one billion Euro in cash ... The claim has been made following an international study ... companies in monetary terms. Entitled Sustainable Value Creation by ... European research team including academics from Queen,s University Management ...
... FEBRUARY 23, 2010 Scientists seeking answers to the complex ... receptors triggers preterm labor, study how genetics and the ... D can suppress factors that make some women more ... support of the March of Dimes. The March ...
... Researchers at the University of Illinois at Chicago Institute ... federal grant to determine whether or not TV food advertising ... project, funded by the National Cancer Institute, is unique because ... the amount of time that children watch TV. "A ...
Cached Biology News:Study highlights sustainable footprint of chemical companies 2Study highlights sustainable footprint of chemical companies 3March of Dimes provides $2.6 million in new funding for preterm birth research 2Do TV ads affect children's diet, obesity? 2
(Date:6/30/2015)... ... June 30, 2015 , ... Students and faculty ... the first half of “Integrative Biotechnology,” an applied biotechnology course team-taught by faculty ... this course combines students from both universities and is taught on both continents. ...
(Date:6/30/2015)... June 30, 2015  NASA astronaut Kjell Lindgren , ... on his first mission to the International Space Station ... to 9 a.m. EDT Tuesday, July 7. Lindgren ... City, Russia . The interviews will be ... highlighting his mission training. To schedule an interview, ...
(Date:6/30/2015)... San Francisco, CA (PRWEB) , ... June 30, ... ... in FMT Patients , Study will provide new insights on mechanics of fecal ... announced a new partnership to study the microbiome of patients undergoing fecal microbiota ...
(Date:6/30/2015)... ... , ... The maximum number of shares proposed to be purchased in the ... unvested restricted stock). On June 29, 2015, the last trading day prior to the ... the OTCBB was $2.29 per share. , The tender offer will expire on July ...
Breaking Biology Technology:Rivier University and Beijing City University Academic and Cultural Exchanges Begin 2NASA Astronaut Preps for First Space Station Mission, Available for Media Interviews 2uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 2uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 3Cryo-Cell Commences Tender Offer to Purchase its Common Stock, Up to 750,000 Shares at $3.25 per Share 2Cryo-Cell Commences Tender Offer to Purchase its Common Stock, Up to 750,000 Shares at $3.25 per Share 3
... 2011 Medicare carrier Palmetto GBA is proposing new processes ... molecular diagnostic tests (MDT) and laboratory-developed tests (LDT) in the ... marks the first known effort by a payer to address ... genetic tests and molecular diagnostics assays. These important ...
... Biodel Inc. (Nasdaq: BIOD ) today reported ... Fourth Quarter Operating Highlights During ... Selected a new lead candidate formulation of ultra-rapid-acting ... trial; Extended an agreement with a pharmaceutical company for ...
... OAKS, Calif., Dec. 6, 2011 Amgen (NASDAQ: ... Drug Administration (FDA) has modified the requirements of the ... Prescribing physicians, patients and institutions are no longer required ... Nplate® NEXUS (Network of EXperts Understanding and Supporting Nplate ...
Cached Biology Technology:Why Medicare Carrier Proposes Major Changes in the Handling of Code Stacked Molecular Test Claims is Topic of December 20 Audio Conference 2Biodel Reports Fourth Quarter Fiscal Year 2011 Financial Results 2Biodel Reports Fourth Quarter Fiscal Year 2011 Financial Results 3Biodel Reports Fourth Quarter Fiscal Year 2011 Financial Results 4Biodel Reports Fourth Quarter Fiscal Year 2011 Financial Results 5Biodel Reports Fourth Quarter Fiscal Year 2011 Financial Results 6Amgen and FDA Agree to Modify Nplate® (Romiplostim) Risk Evaluation and Mitigation Strategy 2Amgen and FDA Agree to Modify Nplate® (Romiplostim) Risk Evaluation and Mitigation Strategy 3Amgen and FDA Agree to Modify Nplate® (Romiplostim) Risk Evaluation and Mitigation Strategy 4Amgen and FDA Agree to Modify Nplate® (Romiplostim) Risk Evaluation and Mitigation Strategy 5Amgen and FDA Agree to Modify Nplate® (Romiplostim) Risk Evaluation and Mitigation Strategy 6Amgen and FDA Agree to Modify Nplate® (Romiplostim) Risk Evaluation and Mitigation Strategy 7Amgen and FDA Agree to Modify Nplate® (Romiplostim) Risk Evaluation and Mitigation Strategy 8
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. ID clarifier: ...
... combines top performance with exquisite design. The ... and unparalleled temperature uniformity. The instrument has ... a spreadsheet or alternatively in a graphical ... on the push of a button and ...
Preparation TW--Compatibility: no end cap seals -Hybridization Tube for Hybrigene -Comp Dim: 240 80 mm -Material: borosilicate glass -Mfr Desig: Techne FHB-15...
... software for all your biopharmaceutical applications needs. ... single, scalable software package. The graphical user ... control of all Freedom instruments from simple ... with one liquid handling arm up to ...
Biology Products: