Navigation Links
UCLA scientists discover how key enzyme involved in aging, cancer assembles
Date:6/19/2012

uent cells."

Overactive telomerase has potentially lethal consequences far beyond the propagation of erroneous DNA. The enzyme is particularly lively within cancer cells, which prevents them from dying out naturally. Finding a way to turn off telomerase in cancer cells might help prevent the diseased cells from multiplying.

Flipping the switch on telomerase might mean stopping it from forming in the first place, said Feigon.

"Any time you want to stop an enzyme, you can target activity, but you can also target assembly," she said. "If you keep it from assembling, that's just as good as keeping it from being active, because it never even forms."

While there is enormous interest in telomerase due to its connection to cancer and aging, very little is known about its three-dimensional structure or its formation, Feigon said.

Four years ago, UCLA postdoctoral scholar Mahavir Singh set out to determine how a strand of RNA and multiple proteins bind together to form telomerase. He set his sights on the p65 protein, one of the key components of the enzyme. Like many proteins, p65 is a long chain of both stiff and supple links that fold in upon one another in a prescribed pattern. At the very end of the p65 protein is a floppy, disordered tail.

"We knew the tail was important for the protein's function, but it wasn't clear how or why," said Singh, first author of the current study. "From the structure, it became evident how it interacts with the telomerase RNA."

When Singh snipped off the flexible tail from p65, he found that the assembly of telomerase became severely limited. The tailless p65 simply couldn't help put together the enzyme.

Using both X-ray crystallography and nuclear magnetic resonance spectroscopy, Singh probed the structure of the protein and its interaction with telomerase RNA. He found that upon assembly, the flexible tail transforms into a rigid crowbar that pries apa
'/>"/>

Contact: Stuart Wolpert
swolpert@support.ucla.edu
310-206-0511
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scientists reconstruct pre-Columbian human effects on the Amazon Basin
2. Scientists tie DNA repair to key cell signaling network
3. Top young Latin-American scientists named Pew Biomedical Fellows
4. 22 of Americas most promising scientists selected as Pew Biomedical Scholars
5. Berkeley Lab scientists help define the healthy human microbiome
6. Consortium of scientists maps the human bodys bacterial ecosystem
7. Citizen scientists to document biodiversity with high-resolution imagery during summer solstice
8. Evaluation of microscopy techniques may help scientists to better understand ancient plants
9. Dont feel like exercise? Scientists find compound that may help you work out harder
10. Scientists identify mechanism for regulating plant oil production
11. NYBG scientists identify 81 new plant and fungus species
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/20/2015)... 19, 2015 Research and Markets ( http://www.researchandmarkets.com/research/rswjb4/hand_geometry ... - Global Strategic Business Report" report to their offering. ... Geometry in US$ Thousands. The report provides separate comprehensive analytics ... Japan , Europe , ... Rest of World. Annual estimates and forecasts are ...
(Date:3/18/2015)... , March 18, 2015 As mobile ... new revolutionary smart wallets and apps continue to be introduced ... entrenched in the mobile payment industry in focus today are:  ... Ltd. (NYSE: BABA ), Apple Inc. (NASDAQ: ... and Facebook Inc. (NASDAQ: FB ) ...
(Date:3/16/2015)... 16, 2015 Between 16 ... present groundbreaking innovations in biometric identification at the ... .      (Photo: http://photos.prnewswire.com/prnh/20150316/735333 ... is well at the forefront: the company,s all ... in Germany . BiometricGate is ...
Breaking Biology News(10 mins):Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 2Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 6DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 3
... Artificial Gravity , edited by Gilles Clment and Angie Bukley, ... International Academy of Astronautics. This award is given annually to ... in the fields related to life science. The award will ... September 2008 in Glasgow, Scotland. Artificial Gravity ...
... Strange things are happening in the lowland tropical forests ... fly is affecting the social behavior of a nocturnal ... which become workers. The finding by researchers from ... Institute is the first documented example of a parasite ...
... Medical School at Houston say they are the first ... or pre-eclampsia may be an autoimmune disease. Their research ... intractable disease. Findings appear online in Nature Medicine ... of Yang Xia, M.D., Ph.D., an assistant professor of ...
Cached Biology News:A bee's future as queen or worker may rest with parasitic fly 2Pre-eclampsia may be autoimmune disease 2Pre-eclampsia may be autoimmune disease 3
(Date:3/26/2015)... CINCINNATI , March 26, 2015 ... NASDAQ: SHPG ) and Cincinnati Children,s Hospital ... collaboration for rare diseases. The goal of the collaboration ... treat rare diseases with high unmet medical need ... Children,s research expertise. As a nationally ranked hospital, ...
(Date:3/26/2015)... March 26, 2015 PAREXEL International ... clinical research organization , announced today ... agreement to acquire all of the business ... leading provider of specialized pharmacovigilance services, based ... collection, detection, assessment, monitoring, and prevention of ...
(Date:3/26/2015)... "In America," the popular news television program that airs in ... legendary film actor James Earl Jones, has announced that it ... , Botany is commonly described as the scientific study ... bit more complicated than that. Scientists and other professionals study ... the smallest bacteria known to man to the largest trees ...
(Date:3/26/2015)... Cranford, NJ (PRWEB) March 26, 2015 ... has partnered with researchers from Yale University’s School of ... provided by study participants during a 4 month-long project. ... impact of providing low income families with free access ... eating habits and diet-related health concerns like high blood ...
Breaking Biology Technology:Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 2Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 3Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 4Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 5PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 2PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 3PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 4Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 2Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 3
... -- Sinovac Biotech Ltd. (Amex:,SVA), a vaccine-focused biotech company ... Annual Meeting of Shareholders on Tuesday, March 25,2008 at ... concurrently at,No. 39 Shangdi Xi Road, Haidian District, Beijing, ... All shareholders of record as of January 28,2008 will ...
... -- China Technology,Development Group Corporation (Nasdaq: CTDC; "the ... energy products and solutions focusing on,solar energy business ... it has,appointed Deloitte Touche Tohmatsu CPA Ltd. ("Deloitte") ... year ended December 31, 2007, following,the expiry of ...
... Feb. 19 /PRNewswire-FirstCall/ - AEterna Zentaris Inc.,(NASDAQ: AEZS ... therapy and oncology, today announced that its President and ... at the Roth Capital,Partners 20th Annual OC Growth Stock ... the Ballroom of the Ritz Carlton Laguna Niguel in ...
Cached Biology Technology:Sinovac Biotech Ltd. Schedules 2007 Annual Meeting of Shareholders 2China Technology Appoints Deloitte Touche Tohmatsu CPA as Independent Auditor 2
DNA Polymerase I Large (Klenow) Fragment is a DNA polymerase that lacks the 5'Cut Site3' exodeoxyribonuclease activity of intact DNA Polymerase I but it contains the 3'Cut Site5' exodeoxyribonuclease...
Guanylate Kinase Purified Anti-Mouse, Anti-Rat clone 28, Isotype Mouse IgG 1 , 50 µg Consult technical datasheet for details....
Proliferin (C-14)...
... your ValveBank system! Program your valve ... computer using graphic 'click-and-drag' timebars. Save and ... program listings, then download your programs into ... EasyCode is used for programming before -- ...
Biology Products: