Navigation Links
UCLA scientists discover how key enzyme involved in aging, cancer assembles
Date:6/19/2012

uent cells."

Overactive telomerase has potentially lethal consequences far beyond the propagation of erroneous DNA. The enzyme is particularly lively within cancer cells, which prevents them from dying out naturally. Finding a way to turn off telomerase in cancer cells might help prevent the diseased cells from multiplying.

Flipping the switch on telomerase might mean stopping it from forming in the first place, said Feigon.

"Any time you want to stop an enzyme, you can target activity, but you can also target assembly," she said. "If you keep it from assembling, that's just as good as keeping it from being active, because it never even forms."

While there is enormous interest in telomerase due to its connection to cancer and aging, very little is known about its three-dimensional structure or its formation, Feigon said.

Four years ago, UCLA postdoctoral scholar Mahavir Singh set out to determine how a strand of RNA and multiple proteins bind together to form telomerase. He set his sights on the p65 protein, one of the key components of the enzyme. Like many proteins, p65 is a long chain of both stiff and supple links that fold in upon one another in a prescribed pattern. At the very end of the p65 protein is a floppy, disordered tail.

"We knew the tail was important for the protein's function, but it wasn't clear how or why," said Singh, first author of the current study. "From the structure, it became evident how it interacts with the telomerase RNA."

When Singh snipped off the flexible tail from p65, he found that the assembly of telomerase became severely limited. The tailless p65 simply couldn't help put together the enzyme.

Using both X-ray crystallography and nuclear magnetic resonance spectroscopy, Singh probed the structure of the protein and its interaction with telomerase RNA. He found that upon assembly, the flexible tail transforms into a rigid crowbar that pries apa
'/>"/>

Contact: Stuart Wolpert
swolpert@support.ucla.edu
310-206-0511
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scientists reconstruct pre-Columbian human effects on the Amazon Basin
2. Scientists tie DNA repair to key cell signaling network
3. Top young Latin-American scientists named Pew Biomedical Fellows
4. 22 of Americas most promising scientists selected as Pew Biomedical Scholars
5. Berkeley Lab scientists help define the healthy human microbiome
6. Consortium of scientists maps the human bodys bacterial ecosystem
7. Citizen scientists to document biodiversity with high-resolution imagery during summer solstice
8. Evaluation of microscopy techniques may help scientists to better understand ancient plants
9. Dont feel like exercise? Scientists find compound that may help you work out harder
10. Scientists identify mechanism for regulating plant oil production
11. NYBG scientists identify 81 new plant and fungus species
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/km7m5t/natural_language ... "Natural Language Processing Market by Type (Rule-Based, Statistical, ... Image Recognition) - Worldwide Forecast to 2020" ... vendors occupying the market are 3M, Apple, Dolbey ... Solutions, SAS Institute Inc., Verint Systems among various ...
(Date:6/29/2015)... 24, 2015 Research and ... "Latin America Biomedical Sensors Market - Growth, Trends ... The Latin America Biomedical Sensors market is estimated ... 2.04% over the period 2014-2020 The near ... the genetic formulation of each individual. These sensors can ...
(Date:6/24/2015)... -- The biologics safety testing market is growing at ... include growth of the pharmaceutical and biological industries and ... years, the number of drug approvals in North American ... approved 225 drug applications and Health Canada approved 99. ... accounted for 3,822 of the pharmaceutical and 1,998 ...
Breaking Biology News(10 mins):Natural Language Processing Market by Type (Rule-Based, Statistical, and Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) - Worldwide Forecast to 2020 2Latin America Biomedical Sensors Market Report 2015-2020 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 3Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 4
... Monmouth University,s Urban Coast Institute will host its third ... from 10 a.m. to 12 p.m., in the Woodrow ... Ocean Literate Society: Building Communities for Action," will envision ... communication will be used to increase the general publics ...
... adults rely on signals from distant brain regions to ... with existing neighboring cellsa finding that has important implications ... replace brain cells lost by trauma or neurodegeneration, Yale ... Neuroscience. In fact, certain important synaptic connectionsthe circuitry ...
... can combine chemically rather than biologically to form the building ... These processes might have taken place on primitive earth, but ... the University of Georgia have now proposed the first detailed, ... building blocks of DNA, might be built up from the ...
Cached Biology News:Abel to receive posthumous Ocean and Coastal Leadership award 2How did chemical constituents essential to life arise on primitive Earth? 2
(Date:7/28/2015)... (PRWEB) , ... July 28, 2015 , ... ... more than EUR 1.022 billion in 2013; while production volume reached close to ... leading producing country with a share of 75.5% of the region’s total aluminium ...
(Date:7/28/2015)... July 28, 2015 Deerfield Management Company, L.P. ... Fund, L.P., which will invest in groundbreaking advancements in ... diseases, cancer, and orphan diseases. The venture capital fund ... therapeutics are developed and improve the way healthcare is ... the largest healthcare-focused venture funds in the sector, will ...
(Date:7/28/2015)... , July 28, 2015 BioStructures, LLC, ... has hit a milestone of 4,000 implantations of ... 510(k) cleared in early 2014 as a bone ... spine fusion procedures.  This is a distinguished status ... than 6% of new synthetic products have received ...
(Date:7/28/2015)... NESS ZIONA, Israel ... CollPlant Ltd. (TASE:CLPT; OTC:CQPTY), a regenerative medicine company ... repair products, today announced that Shomrat Shurtz has ... September 20, 2015.      (Photo: ... brings over 25 years of experience in marketing, ...
Breaking Biology Technology:EU27 Aluminium Hydroxide Market Analysed and Forecast by BAC Reports in New Research Study Available at MarketPublishers.com 2EU27 Aluminium Hydroxide Market Analysed and Forecast by BAC Reports in New Research Study Available at MarketPublishers.com 3Deerfield Launches $550 Million Healthcare Venture-Capital Fund 2Deerfield Launches $550 Million Healthcare Venture-Capital Fund 3Revolutionary Bone Graft Exceeds Expectations 2CollPlant Names Shomrat Shurtz Senior Director of Business Development 2
... CALGARY, Oct. 2 /PRNewswire-FirstCall/ - Oncolytics Biotech Inc. ("Oncolytics" ... with the terms of the warrant indenture for those ... with the terms of the broker warrant certificates for ... Corporation has provided the required written notice to holders ...
... -- The Board of Directors of Sigma-Aldrich( )Corporation (Nasdaq: ... a Director of the Company. Dr. Church (age 55) ... and Director of the Center for Computational Genetics in Cambridge, ... development of key fields in Chemistry and Biomedicine with over ...
... Oct. 2 /PRNewswire-FirstCall/ - avVaa World Health Care Products ... and distributor of nationally branded therapeutic, natural skin and ... their Neuroskin(R) Psoriasis Relief DRTV commercial during the two ... Inc. is launching a two week DRTV media test ...
Cached Biology Technology:Oncolytics Biotech(R) Inc. Accelerates Warrant Expiry Date 2Sigma-Aldrich Elects George M. Church as Director 2avVaa World Health Care Products Inc. Announces DRTV Test Television Stations 2avVaa World Health Care Products Inc. Announces DRTV Test Television Stations 3
... Antigen Afinity Purified Tyrosine ... polyclonal antibody was raised against ... acids residues surrounding the phospho-Ser40 ... The antibody was purified by ...
Monoclonal Antibody to GLP Immunogen: Ni-NTA purified truncated recombinant GLP expressed in E. Coli strain BL21 (DE3)...
Biotin anti-human CD164...
Co-precipitant is free of background polynucleotides,Dnases,Rnases, proteases. 20mg/ml...
Biology Products: