Navigation Links
UCLA scientists discover how key enzyme involved in aging, cancer assembles
Date:6/19/2012

UCLA biochemists have mapped the structure of a key proteinRNA complex that is required for the assembly of telomerase, an enzyme important in both cancer and aging.

The researchers found that a region at the end of the p65 protein that includes a flexible tail is responsible for bending telomerase's RNA backbone in order to create a scaffold for the assembly of other protein building blocks. Understanding this protein, which is found in a type of single-celled organism that lives in fresh water ponds, may help researchers predict the function of similar proteins in humans and other organisms.

The study was published June 14 in the online edition of the journal Molecular Cell and is scheduled for publication in the print edition on July 13.

The genetic code of both the single-celled protozoan Tetrahymena and humans is stored within long strands of DNA packaged neatly within chromosomes. The telomerase enzyme helps create telomeres protective caps at the ends of the chromosomes that prevent the degradation of our DNA, said Juli Feigon, a UCLA professor of chemistry and biochemistry and senior author of the study.

Each time the cell divides, the telomeres shorten, acting like the slow-burning fuse of a time bomb. After many divisions, the telomeres become eroded to a point that can trigger cell death.

Cells with abnormally high levels of telomerase activity constantly rebuild their protective chromosomal caps, allowing them to replicate indefinitely and become, essentially, immortal. Yet undying cells generally prove to be more of a curse than a blessing, Feigon said.

"Telomerase is not very active in most of our cells because we don't want them to live forever," said Feigon, who is also a researcher at UCLA's Molecular Biology Institute and a member of the National Academy of Sciences. "After many generations, DNA damage builds up and we wouldn't want to pass those errors on to subseq
'/>"/>

Contact: Stuart Wolpert
swolpert@support.ucla.edu
310-206-0511
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scientists reconstruct pre-Columbian human effects on the Amazon Basin
2. Scientists tie DNA repair to key cell signaling network
3. Top young Latin-American scientists named Pew Biomedical Fellows
4. 22 of Americas most promising scientists selected as Pew Biomedical Scholars
5. Berkeley Lab scientists help define the healthy human microbiome
6. Consortium of scientists maps the human bodys bacterial ecosystem
7. Citizen scientists to document biodiversity with high-resolution imagery during summer solstice
8. Evaluation of microscopy techniques may help scientists to better understand ancient plants
9. Dont feel like exercise? Scientists find compound that may help you work out harder
10. Scientists identify mechanism for regulating plant oil production
11. NYBG scientists identify 81 new plant and fungus species
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... examples of complex systems. Their infrastructure equipment requires ... cooling, transport to supply fuel, and ICT systems ... network chain is interconnected with a wider network ... of UK-based scientists has studied various aspects of ... been published in EPJ B by Gaihua Fu ...
(Date:8/28/2014)... This news release is available in German . ... electronic products are now built with the help of sophisticated ... are fixed, are an important part of these assembly lines. ... are attached in various work stages arranged in a precise ... the end of the line. , The creation of such ...
(Date:8/28/2014)... Protected areas conserve biodiversity and more action is needed ... areas, researchers say. , Published in PLOS ONE ... University of Exeter, used meta-analysis - combining results from ... years of research into these areas, to determine whether ... School of Biological Sciences, said protecting an area from ...
Breaking Biology News(10 mins):Inter-dependent networks stress test 2Nanoscale assembly line 2Nanoscale assembly line 3Protected areas proven to protect biodiversity 2
... Irvine, Calif., July 12, 2011 UC Irvine researchers ... customized therapies for virulent flu strains that resist current ... Amaro and Robin Bush created a method to predict ... promoting viral replication can be identified as these proteins ...
... The National Heart, Lung and Blood Institute, one of ... at the Johns Hopkins University School of Medicine each ... establish two Programs of Excellence in Glycosciences. Gerald Hart, ... professor of pharmacology and molecular sciences, will lead these ...
... Beach, FL. New research findings to be presented ... Study of Ingestive Behavior (SSIB), the foremost society for research ... ghrelin, a natural gut hormone that stimulates feeding, also modulates ... dopamine levels within the striatum, a critical component of the ...
Cached Biology News:UCI study points to new means of overcoming antiviral resistance in influenza 2Johns Hopkins researchers awarded $32 million 2
(Date:8/28/2014)... Best Sanitizers, Inc., a leader in hand ... is asking industry professionals to prepare for fall harvest ... soap they’re currently using to the Best Sanitizers’ ... hygiene is critical to fighting cross-contamination and the spread ... criteria are identified to evaluate the effectiveness of an ...
(Date:8/28/2014)... , Aug. 28, 2014 /PRNewswire/ ... new market research report is ... Whole Exome Sequencing Market ... Preparation, Target Enrichment), by Services ... Synthesis), by Application (Cancer, Monogenic ...
(Date:8/28/2014)... PARK, Calif. , Aug. 28, 2014 /PRNewswire/ ... focused on developing novel mid- to late-stage cardiovascular ... $7.0 million in its first round of financing. ... Biomedical Investments and Hercules Bioventures with participation from ... entrepreneur and pharmaceutical executive, Dr. Larry Hsu ...
(Date:8/28/2014)... PrimeSource Building Products, Inc., a ... SoundConnect to support their communication needs with ... web conferencing platform GlobalMeet powered by SoundConnect. The ... SoundConnect delivers award winning “results driven” business ... will be utilizing GlobalMeet powered by SoundConnect ...
Breaking Biology Technology:Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 2Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 3Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 4Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 5Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 6Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 7Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 8Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 9Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 10Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 11Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 12Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 13Armetheon Completes $7.0 Million Series A Financing 2Armetheon Completes $7.0 Million Series A Financing 3PrimeSource Chooses SoundConnect as Collaboration Provider 2
... PALO ALTO, Calif., Feb. 7 Avicena Group, ... that,develops central nervous system therapeutics for neurodegenerative,disorders, announced ... Nivaggioli, Ph.D., will present an overview of the ... BIO CEO & Investor,Conference to be held February ...
... Feb. 7 Logical Therapeutics, Inc., a,biotechnology company ... associated with poorly controlled inflammation, announced today,that its ... presented with the,Distinguished Investigator Award from the American ... Care Congress of the Society of Critical,Care Medicine ...
... Home-Based Device Market Featuring Diode Laser ... Technology for Hair ... in,light-based therapeutic beauty devices, today announced over-the-counter,(OTC) clearance from the ... laser hair removal device designed for at-home,use. The TRIA is ...
Cached Biology Technology:Avicena Group to Present at 10th Annual BIO CEO & Investor Conference 2Avicena Group to Present at 10th Annual BIO CEO & Investor Conference 3Logical Therapeutics Co-Founder and CEO Honored with a Distinguished Investigator Award from the American College of Critical Care Medicine 2TRIA At-Home Laser Hair Removal Device Cleared by FDA 2
...
Anti-Indolamine (Indoleamine) 2,3-dioxygenase Immunogen: Recombinant human IDO. Available Date: 38454...
Anti-Ephrin B1 Host: rabbit polyclonal Species Reactivity: human Applications: WB Storage: 4C...
Human Regulatory T cell Staining Kit #2 (w/ APC Foxp3 PCH101, FITC CD4, PE CD25)...
Biology Products: