Navigation Links
UCLA researchers reconstitute enzyme that synthesizes cholesterol drug lovastatin
Date:11/3/2009

Researchers from the UCLA Henry Samueli School of Engineering and Applied Science have for the first time successfully reconstituted in the laboratory the enzyme responsible for producing the blockbuster cholesterol-lowering drug lovastatin.

The research, published Oct. 23 in the journal Science, could potentially lead to the development of other compounds with similarly beneficial effects.

The lovastatin-synthesizing enzyme is one of the most interesting but least understood of the polyketide synthases, which are found in filamentous fungi and which play a crucial role in the synthesis of "small molecule natural products" pharmacologically or biologically potent compounds produced by living organisms, many of which are the active ingredients in pharmaceuticals.

Commonly used antibiotics, such as tetracycline, are produced by polyketide synthases. Polyketides represent a class of 7,000 known structures, of which more than 20 are commercial drugs, including the immunosuppressant rapamycin, the antibiotic erythromycin and the anticancer drug doxorubicin.

"In this study, we studied the enzyme that makes a small-molecule precursor to lovastatin. And what's really different about this enzyme, compared to all other enzymes people have studied, is that this enzyme is extraordinarily large," said Yi Tang, associate professor of chemical and biomolecular engineering. "It's one of the largest enzymes ever to be reconstituted in a test tube. It is 10 times the size of most enzymes people study."

The enzyme used in Tang's study has seven active sites and catalyzes more than 40 different reactions that eventually result in an important precursor to lovastatin.

By understanding how this large assembly line works, Tang's team hopes to retune the assembly line to be able to produce other natural products something nature doesn't currently do.

"It's like having an assembly line with seven
'/>"/>

Contact: Wileen Wong Kromhout
wwkromhout@support.ucla.edu
310-206-0540
University of California - Los Angeles
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... the University of East Anglia have shown how the ... in cancer patients. , Research published today reveals ... responsible for the drug,s success in shrinking tumours. ... develop a synthetic equivalent with anti-cancer properties. ... de Madridin, Spain. The team used samples of human ...
(Date:7/13/2014)... study in women suggests that experiencing one or more ... meal can slow the body,s metabolism, potentially contributing to ... previous day,s stressors before giving them a meal consisting ... scientists then measured their metabolic rate how long ... and took measures of blood sugar, triglycerides, insulin ...
(Date:7/11/2014)... report from the Wildlife Conservation Society shows that ... economically valuable species such as lobster, conch, and ... re-colonize nearby reef areas. , The reporttitled "Review ... review of research literature from no-take areas around ... Craig Dahlgren, a recognized expert in marine protected ...
Breaking Biology News(10 mins):UEA research reveals how cannabis compound could slow tumour growth 2Weighty issue: Stress and high-fat meals combine to slow metabolism in women 2Weighty issue: Stress and high-fat meals combine to slow metabolism in women 3Weighty issue: Stress and high-fat meals combine to slow metabolism in women 4Belize's lobster, conch, and fish populations rebuild in no-take zones 2
... Mich. Michigan State University veterinarians are taking part ... cancers in dogs, research that could offer new insight ... the human form of the disease. The Canine ... clinicians, nonprofit institutions, universities and industry members will ...
... the Philippines, which aims to develop a new, higher-yielding rice plant ... being led by an academic at the University of Sheffield. ... a dollar a day and nearly one billion live in hunger. ... increase by about 50 per cent and water scarcity will grow. ...
... , NEW YORK, NY June 21, 2010 NYU ... award from the Empire State Stem Cell Boards New York ... be used to expand the NYU RNAi Core Facility and ... School of Medicine. The purpose of the collaboration is ...
Cached Biology News:From bark to bedside: Study looks at canine cancer genes, human health impact 2Rice yields researched to tackle food security issues 2Rice yields researched to tackle food security issues 3NYU Langone Medical Center receives $5.4 million NYSTEM grant for stem cell research 2
(Date:7/11/2014)... WEST PALM BEACH, Fla. , July 11, 2014 ... wide variety of high-quality peptides that are used solely ... online. To honor two successful years in business, Maxim ... Performance LLC, has just launched a new and updated ... addition, the research blog section has been updated with ...
(Date:7/11/2014)... - Sunovion Pharmaceuticals Canada Inc. (Sunovion) today announced that ... use as a once-daily adjunctive therapy for the treatment ... not satisfactorily controlled with conventional therapy.  APTIOM TM ... years of age. Epilepsy is one ... Epilepsy Canada, it affects 0.6% of the population and ...
(Date:7/10/2014)... 10, 2014 Deep Knowledge Ventures ... Forum on ‘Commercialising Longevity Research’ and welcomed a ... the London Bioscience Innovation Center for the event, ... Aging Analytics Ltd. The meeting highlighted the need ... research for age-related disease, as well as the ...
(Date:7/10/2014)... 2014 OMICS Group’s 5th International conference ... August, 2014 at Double Tree by Hilton Beijing, China ... in Analytical & Bioanalytical research methods only to facilitate ... this occasion, Dr. Srinubabu Gedela, MD of OMICS Group ... a remarkable one in bringing a unique and international ...
Breaking Biology Technology:Maxim Peptide Celebrates Second Anniversary Online with an Updated Website and Special Deals Section 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 3Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 2DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 5DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 6A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4
... BEIJING, May 26, 2011 MicroConstants China Inc., a ... and providing full-service early stage clinical trial management in ... with the OECD Principles of Good Laboratory Practice (GLP) ... from the Netherlands GLP Compliance Monitoring Programme . ...
... PARK, N.C. - May 25, 2011 - ... consortium,for semiconductors and related technologies, and researchers ... and Applied Science have,developed a new method ... The advance promises to provide,semiconductor chip manufacturing ...
... La., May 25, 2011 In a new study conducted ... the decrease in workplace physical activity over the past fifty ... study suggests that changes in caloric intake cannot solely account ... women in the United States. The study, entitled ...
Cached Biology Technology:MicroConstants China Receives Endorsement of OECD GLP Compliance 2SRC and UCLA advance design-dependent process monitoring for semiconductor wafer manufacturing 2Pennington Biomedical Research Center Study Suggests Decreases in U. S. Occupation Energy Levels a Significant Trigger of Obesity Epidemic 2Pennington Biomedical Research Center Study Suggests Decreases in U. S. Occupation Energy Levels a Significant Trigger of Obesity Epidemic 3
Mouse monoclonal antibody raised against a partial recombinant EBI3. NCBI Entrez Gene ID = EBI3...
... AS-2055 and AS-2057 are fully automatic sample ... possible level of precision. Sampling flexibility is ... (microplate) for,laboratory automation and combinatorial chemistry. Also ... or the standard rack for 50 2,ml ...
...
... Covance's BCIP/NBT Chromogen system ... Tetrazolium] chromogen in a single ... reacts in the presence of ... purple staining with minimal background ...
Biology Products: