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UCLA researchers make first direct recording of mirror neurons in human brain
Date:4/12/2010

Mirror neurons, many say, are what make us human. They are the cells in the brain that fire not only when we perform a particular action but also when we watch someone else perform that same action.

Neuroscientists believe this "mirroring" is the mechanism by which we can "read" the minds of others and empathize with them. It's how we "feel" someone's pain, how we discern a grimace from a grin, a smirk from a smile.

Problem was, there was no proof that mirror neurons existed only suspicion and indirect evidence. Now, reporting in the April edition of the journal Current Biology, Dr. Itzhak Fried, a UCLA professor of neurosurgery and of psychiatry and biobehavioral sciences, Roy Mukamel, a postdoctoral fellow in Fried's lab, and their colleagues have for the first time made a direct recording of mirror neurons in the human brain.

The researchers recorded both single cells and multiple-cell activity, not only in motor regions of the brain where mirror neurons were thought to exist but also in regions involved in vision and in memory.

Further, they showed that specific subsets of mirror cells increased their activity during the execution of an action but decreased their activity when an action was only being observed.

"We hypothesize that the decreased activity from the cells when observing an action may be to inhibit the observer from automatically performing that same action," said Mukamel, the study's lead author. "Furthermore, this subset of mirror neurons may help us distinguish the actions of other people from our own actions."

The researchers drew their data directly from the brains of 21 patients who were being treated at Ronald Reagan UCLA Medical Center for intractable epilepsy. The patients had been implanted with intracranial depth electrodes to identify seizure foci for potential surgical treatment. Electrode location was based solely on clinical criteria; the researchers, with the patien
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Contact: Mark Wheeler
mwheeler@mednet.ucla.edu
310-794-2265
University of California - Los Angeles
Source:Eurekalert

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