Navigation Links
UCLA researchers locate and image prostate cancer as it spreads to lymph nodes
Date:7/11/2008

Using an engineered common cold virus, UCLA researchers delivered a genetic payload to prostate cancer cells that allowed them, using Positron Emission Tomography (PET), to locate the diseased cells as they spread to the lymph nodes, the first place prostate cancer goes before invading other organs.

The tiny cancer metastases in the pelvic lymph nodes are very difficult to find using conventional imaging tools such as CT scanning. This discovery could aid oncologists in finding the cancer's spread earlier, when it's more treatable, and before it invades distant organs, said Lily Wu, a researcher at UCLA's Jonsson Cancer Center and the senior author of the study.

The next step for Wu and her colleagues is linking the non-invasive imaging advance with a treatment component, activating a toxic agent in the genetic payload to kill the spreading cancer cells. Wu hopes one day to be able to find tiny prostate cancer metastases in patients and kill them at the same time, watching it all on a PET scanner. She currently is refining this image-guided therapy in her lab in mouse models.

"I think this is very exciting for many reasons," said Wu, who also is an associate professor of pharmacology and urology. "We now know we can reach these prostate cancer metastases at an earlier stage than before, and we know we can deliver genes to those cancer cells that produce proteins that can be imaged by PET. Now we will find out how effective this genetic toxic payload is in preventing further spread of the cancer to other vital organs."

The study appears July 11, 2008 in the early, online edition of the peer-reviewed journal Nature Medicine.

The spread of prostate cancer to the pelvic lymph nodes is the most reliable indicator that the patient will have a poor prognosis, with disease recurrence and progression likely. Accurately assessing pelvic lymph node involvement in patients is critical in planning their treatment,
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert  

0

GOOD

Page: 1 2 3

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCLA researchers locate and image prostate cancer as it spreads to lymph nodes
UCLA researchers locate and image prostate cancer as it spreads to lymph nodes
(Date:1/7/2009)..., RESTON, Virginia, January 7 /PRNewswire/ ...ider of high-performance search and match software...d the company as Vice President of,Sales for the ...ive in the biometrics and ID management,industry....utions, where he,was responsible for strategic pr...
(Date:1/7/2009)..., The molecular details of Aromatase, the key enz... longer a mystery thanks to the structural biology...rd Medical Research Institute (HWI) in Buffalo, Ne...e-dimensional structure of aromatase is the first ...he mechanism of synthesizing estrogen. , In fac...
(Date:1/7/2009)..., Boston, Mass. January 07, 2009 A special issu... Part B: Neuropsychiatric Genetics presents a com...tic research of Attention Deficit/Hyperactivity Di...e field of complex psychiatric genetics, underscor...what approaches are needed to uncover its genetic ...
(Date:1/7/2009)..., Observing and betting on cricket fights has b...ast the Sung Dynasty (A.D. 960-1278). This ancient... characteristics that Chinese practitioners think ...olved, there was a strong incentive for the practi...hters closely," says Kevin Judge, a biology postdo...
Breaking Biology News(10 mins):HWI scientist first in world to unravel structure of key breast cancer target enzyme 2HWI scientist first in world to unravel structure of key breast cancer target enzyme 3Studies examine genetic determinants of ADHD 2Male crickets with bigger heads are better fighters, study reveals, echoing ancient Chinese text 2UC San Diego launches Institute of Engineering in Medicine to accelerate health care tech 4102 1UC San Diego launches Institute of Engineering in Medicine to accelerate health care tech 4102 2UC San Diego launches Institute of Engineering in Medicine to accelerate health care tech 4102 3Michael J Fox Foundation Awards 242 4 Million for Validation of Nine Promising Therapeutic Targets for Parkinsons Disease 2658 1Michael J Fox Foundation Awards 242 4 Million for Validation of Nine Promising Therapeutic Targets for Parkinsons Disease 2658 2Michael J Fox Foundation Awards 242 4 Million for Validation of Nine Promising Therapeutic Targets for Parkinsons Disease 2658 3EPA releases report on climate change and health 4096 1AGM EGM Postponed to July 20 2008 6620 1
...like roses and grapevines develop into a tumor? Th... that is able to "smell" the wound and speed up th...logist Steve Winans says that the pathogen Agroba...ies the genes required for infection, which can sl...ausing a cancer-like disease called crown gall. Th...
...of how humans differ from one another at the DNA l...has shaped the recent evolution of our species, ac...lera Genomics and Celera Diagnostics. , In a stud...ture, Cornell scientists analyzed 11,624 genes, co...t also between the humans and a chimpanzee, whose ...
...he main product they are used in - beer - has rapi...help prevent many types of cancer. , Researchers a...cer-related properties of this flavonoid compound ...blication by an OSU researcher in the journal Phyt...ce then. And many other scientists in programs aro...
...ed LEDGF is the first such molecule found to contr... according to a new study from researchers at the ...his study, published in this week,s early online e...ar target for modulating where viruses insert into...er design of gene-therapy delivery. Retroviral vec...
Other Biology News:Plant wounds trigger bacteria 2Cornell finds natural selection in humans 2Cornell finds natural selection in humans 3Anti-cancer Compound In Beer Gaining Interest 2Anti-cancer Compound In Beer Gaining Interest 3HIV inserts into human genome using a DNA-associated protein 2
(Date:1/8/2009)...e-FirstCall/ -- Amicus Therapeutics (Nasdaq: FOL...Ph.D., to its Board of Directors. Dr. Barer curre...r of Celgene Corporation. As an industry veteran,...rience and a reputation as a trusted and respected...of the world,s preeminent biopharmaceutical compan...
(Date:1/8/2009)...8 Palomar Medical Techno...er and developer of light-based systems for cosmet...its international distribution agreement with the ...ckholm Mid Cap:QMED), a leading biotech/medical de...ational distribution agreement was originally ente...
(Date:1/7/2009)...Newswire-FirstCall/ -- Amgen (Nasdaq: AMGN ) wil...thcare Conference at 9:00 a.m. Pacific Time on Mon...an Francisco, Calif. Amgen Chairman and CEO Kevin... of the presentation will be available over the In... www.amgen.com , under Investors. , , (Logo: ...
(Date:1/7/2009).../ -- Cold season has settled in for the,winter mo...for doctor,appointments and missed days of school...boost your immune system. And Immunity Enhanced Be...ntly introduced by Innovative Beverage Products, I...uid supplement intended to strengthen the,body,s ...
Breaking Biology Technology:Amicus Therapeutics Adds Sol J. Barer, Ph.D. to Board of Directors 2Palomar and Q-MED AB Terminate International Distribution Agreement 2Palomar and Q-MED AB Terminate International Distribution Agreement 3Palomar and Q-MED AB Terminate International Distribution Agreement 4Palomar and Q-MED AB Terminate International Distribution Agreement 5Innovative Beverage Products Launches New Product Designed to Enhance the Body's Immune Defense 2
...time gains due to Hurricane Katrina and other Gulf...a net loss of nearly $45 million, or 20 cents per ...rmation management services firm reported net inco... reported in the fourth quarter of 2005, a drop of...art to unpredictable events such as the $31.5 mill...
... of Chris Shipley,s keynote speech given to open t...if. , , I shouldn,t be surprised by the energy i... at the very center of an exciting shift in the in...comes increasingly distributed, individuals themse...ly, we have struggled to find a name for this powe...
...sin will create 200 new union jobs in Milwaukee t...o service that soon will be available in the Milwa.... VanderSanden, president of AT&T Wisconsin, and S...ons Workers of America (CWA), said the new jobs w...ukee St. , ,AT&T, which already has call centers i...
...stics, therapeutics, or prognosis? While all are i...ory has addressed this question and also how recen... diagnostics units, shed light on this fundamental...ine for granted, to not delve too deeply into its ... appeared. However, considering the historical ori...
Other Biology Technology:Age of empowered individuals: People power behind robust computing 2Age of empowered individuals: People power behind robust computing 3Age of empowered individuals: People power behind robust computing 4Age of empowered individuals: People power behind robust computing 5A prognosis for GE and Abbott Diagnostics 2A prognosis for GE and Abbott Diagnostics 3A prognosis for GE and Abbott Diagnostics 4A prognosis for GE and Abbott Diagnostics 5A prognosis for GE and Abbott Diagnostics 6A prognosis for GE and Abbott Diagnostics 7
Antibodies were affinity purified using epitopes specific to PPP1CC immobilized on solid support.
...er Supply, 1. 3500 V, 400 mA, 200 W maximum.Consta...linear voltage ramp modes.Linear voltage ramp mode...ips quickly without danger of overheating.Volt-hou...ions in gel thickness, sample ionic strength, and ...
Human Aminopeptidase P1/XPNPEP1 Affinity Purified PAb Protein Family: Aminopeptidases, Metalloproteases
Template and primers for preparation of internal control spots
Biology Products: