Navigation Links
UCLA researchers find new clue to cause of human narcolepsy
Date:7/3/2013

is also present in a type of brain cell.

For the study, researchers examined five narcoleptic brains and seven control brains from human cadavers. Prior to death, all the narcoleptics had been diagnosed by a sleep disorder center as having narcolepsy with cataplexy. These brains were also compared with the brains of three narcoleptic mouse models and to the brains of narcoleptic dogs.

The researchers found that the humans with narcolepsy had an average of 64 percent more histamine neurons. Interestingly, the team did not see an increased number of these cells in any of the animal models of narcolepsy.

"Humans and animals with narcolepsy share the same symptoms, but we did not see the histamine cell changes we saw in humans in the animal models we examined," said Siegel, who directs the Center for Sleep Research at the UCLA Semel Institute for Neuroscience and Human Behavior and is the senior author of the research. "We know that narcolepsy in the animal models is caused by engineered genetic changes that block hypocretin function. However, in humans, we did not know why the hypocretin cells die.

"Our current findings indicate that the increase of histamine cells that we see in human narcolepsy may cause the loss of hypocretin cells," he said.

The study results may also further our understanding of brain plasticity, Siegel noted. While scientists have known of the existence of neurogenesis the process by which the brain is populated with new neurons it was thought to function mainly to replace existing cells that had died.

"This paper shows for the first time that neuronal numbers can increase greatly and not just serve as replacement cells," he said. "In the current example, this appears to be pathological with the destruction of hypocretin, but in other circumstances, it may underlie recovery and learning and open new routes to treatment of a number of neurological disorders."


'/>"/>

Contact: Mark Wheeler
mwheeler@mednet.ucla.edu
310-794-2265
University of California - Los Angeles
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover new way to block inflammation
2. Researchers call for rethinking efforts to prevent interplanetary contamination
3. Northwestern researchers examine mechanical bases for the emergence of undulatory swimmers
4. Researchers determine factors that influence spinach contamination pre-harvest
5. Researchers discover how a mutated protein outwits evolution and fuels leukemia
6. CNIO researchers discover a new gene involved in obesity
7. Too green to be true? Researchers develop highly effective method for converting CO2 into methanol
8. UMass Amherst researchers develop powerful new technique to study protein function
9. Saint Louis University researchers discover a way to detect new viruses
10. OU researchers collaborate on $20 million NSF EPSCoR grant
11. Researchers unearth bioenergy potential in leaf-cutter ant communities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2015)... SAN JOSE, Calif. , July 13, 2015 ... the leading developer of human interface solutions, today ... second generation touch and display driver integration (TDDI) ... solution is the first to combine Synaptics , ... expertise with proven display driver technology developed in ...
(Date:7/9/2015)... Calif. , July 9, 2015  Synaptics Inc. (NASDAQ: ... solutions, announced today that it will report financial results ... Thursday, July 30, 2015 after the close of market. ... analysts and investors at 2:00 p.m. PT (5:00 p.m. ... To participate on the live call, analysts ...
(Date:7/9/2015)... 9, 2015  Unchained Labs just can,t get ... of Avid Nano. Avid Nano designs, develops and ... Also today, Unchained Labs UNcaged ... to use protein sizing system. The pUNk is ... hydrodynamic size, size distribution, aggregation population and molecular ...
Breaking Biology News(10 mins):Synaptics Announces Sampling of Second Generation TDDI Solutions 2Synaptics Announces Sampling of Second Generation TDDI Solutions 3Synaptics to Report Fourth Quarter, Fiscal Year 2015 Results on July 30 2Unchained Labs just can't get enough, acquires Avid Nano, rocks out the new pUNk! 2
... by global warming, habitat loss, and other human impacts. ... functioning of ecosystems that humans depend on for goods and ... their primary functions with fewer species in them? After ... Earth, are scientists any closer to attaining these answers? ...
... Maps are great for showing where things are. ... Two Michigan State University professors have developed interactive maps ... By using GIS (geographic information systems) technology, they are ... losing access to fresh produce and balanced nutrition. ...
... Nottingham have joined forces with colleagues at Loughborough University and ... keep the mould at bay for longer. Cold plasma ... from wounds safely. It was a chance discovery that led ... cold plasma might also be useful in the food sector. ...
Cached Biology News:Will loss of plant diversity compromise Earth's life-support systems? 2Will loss of plant diversity compromise Earth's life-support systems? 3Will loss of plant diversity compromise Earth's life-support systems? 4Will loss of plant diversity compromise Earth's life-support systems? 5Mapping food deserts 2Keeping soft fruit 'fur-free' for longer 2
(Date:7/27/2015)... July 27, 2015 The Brain ... winners of its annual Klerman and Freedman Prizes, ... who have been supported by NARSAD Young Investigator ... pursue innovative ideas in neurobiological and psychosocial research, ... for the early detection, treatment, prevention and cure ...
(Date:7/27/2015)... Maine , July 27, 2015 IDEXX ... more than 8,000 clinics have submitted over 100,000 specimens ... testing in just the first 10 days since the ... kidney disease (CKD) is a leading cause of suffering ... the submitted specimens are consistent with generally accepted kidney ...
(Date:7/26/2015)... ... July 26, 2015 , ... Maine ... calibration verification / linearity test kit. The VALIDATE® ANEMIA kit contains Ferritin, Folate, ... is prepared using the CLSI recommended “equal delta” method for linearity testing and ...
(Date:7/24/2015)... -- Ryan & Maniskas, LLP that a class ... for the Northern District of California ... common stock of Avalanche Biotechnologies, Inc. ("Avalanche" or the "Company") ... 15, 2015, inclusive (the "Class Period"). Avalanche shareholders ... for appointment as a lead plaintiff of the Class.  If ...
Breaking Biology Technology:Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 2Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 3Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 4Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 5Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 6Over 100,000 Pets Tested with New IDEXX SDMA Kidney Function Test Since Product Launch on July 13 2Over 100,000 Pets Tested with New IDEXX SDMA Kidney Function Test Since Product Launch on July 13 3Over 100,000 Pets Tested with New IDEXX SDMA Kidney Function Test Since Product Launch on July 13 4Over 100,000 Pets Tested with New IDEXX SDMA Kidney Function Test Since Product Launch on July 13 5Maine Standards Company, LLC Announces Release of VALIDATE® ANEMIA Calibration Verification / Linearity Test Kit 2Ryan & Maniskas, LLP Announces Class Action Lawsuit Against Avalanche Biotechnologies, Inc. 2Ryan & Maniskas, LLP Announces Class Action Lawsuit Against Avalanche Biotechnologies, Inc. 3
... Diplomat Specialty,Pharmacy today announced that Dr. Atheer ... Dr. Kaddis will serve as Vice President of,Managed ... Diplomat Specialty,Pharmacy,s President and CEO, Philip Hagerman. ... Managed Care,expertise we need to further develop competitive, ...
... 22 Laser Energetics,Inc. (Pink Sheets: LNGT) announced ... several medical and dental instrument suppliers regarding,the integration ... dental products. LEI,s BrightStar(TM) Alexandrite laser,s shorter ... system can enhance medical and,dental laser applications. The ...
... Shared Through Dynamic WikiAnswers Q&A ... ... show of support for National,Breast Cancer Awareness Month, Answers.com,s question and ... where breast cancer survivors,friends and family have gathered to ask questions ...
Cached Biology Technology:Diplomat Specialty Pharmacy Hires Vice President of Managed Markets 2Laser Energetics to Integrate BrightStar(TM) Alexandrite Lasers in Medical and Dental Applications 2Laser Energetics to Integrate BrightStar(TM) Alexandrite Lasers in Medical and Dental Applications 3Answers.com's WikiAnswers Supervisors Rallying for National Breast Cancer Awareness Month 2Answers.com's WikiAnswers Supervisors Rallying for National Breast Cancer Awareness Month 3
... The DNA quantitation kit is used to ... the presence of RNA or protein. With this ... which can be detected with a VersaFluor or ... range of 10 ng per ml to 5 ...
... stimulating factors for assays of mouse hematopoietic ... fetal liver. Suitable for the growth ... when added to methylcellulose at a final ... Will also support growth of mouse ...
ImmunoPure Plus Immobilized Protein G, , , , Support: Cross-linked 6%, beaded agarose , Capacity: > 20 mg human IgG/ml of gel ...
...
Biology Products: