Navigation Links
UCLA researchers engineer E. coli to produce record-setting amounts of alternative fuel
Date:3/17/2011

Researchers at UCLA's Henry Samueli School of Engineering and Applied Science have developed a way to produce normal butanol often proposed as a "greener" fuel alternative to diesel and gasoline from bacteria at rates significantly higher than those achieved using current production methods.

The findings, reported online in the journal Applied and Environmental Microbiology, mark an important advance in the production of normal butanol, or n-butanol, a four-carbon chain alcohol that has been shown to work well with existing energy infrastructure, including in vehicles designed for gasoline, without modifications that would be required with other biofuels.

The UCLA team, led by James C. Liao, UCLA's Chancellor's Professor of Chemical and Biomolecular Engineering, demonstrated success in producing 15 to 30 grams of n-butanol per liter of culture medium using genetically engineered Escherichia coli a record-setting increase over the typical one to four grams produced per liter in the past.

For the study, Liao and his team initially constructed an n-butanol biochemical pathway in E. coli, a microbe that doesn't naturally produce n-butanol, but found that production levels were limited. However, after adding metabolic driving forces to the pathway, the researchers witnessed a tenfold increase in the production of n-butanol. The metabolic driving forces pushed the carbon flux to n-butanol.

"Like human beings, microbes need an incentive to work," said Liao, the study's senior author.

"We created driving forces by genetically engineering the metabolism," said Claire R. Shen, a UCLA Engineering graduate student and lead author of the study.

While certain microbes, including species of the bacteria Clostridium, naturally produce n-butanol, Liao's team used E. coli because it is easier to manipulate and has been used industrially in producing various chemicals.

"By u
'/>"/>

Contact: Wileen Wong Kromhout
wwkromhout@support.ucla.edu
310-206-0540
University of California - Los Angeles
Source:Eurekalert

Page: 1 2

Related biology news :

1. Hopkins researchers use light to move molecules
2. Zoo researchers provide African sanctuaries road map
3. Brandeis researchers use lasers, custom microscope to show gene splicing process in real time
4. Synthetic biology: TUM researchers develop novel kind of fluorescent protein
5. Researchers find drug that stops progression of Parkinsons disease in mice
6. Researchers discover new wintering grounds for humpback whales using sound
7. Berkeley Lab researchers illuminate laminins role in cancer formation
8. Researchers discover new shapes of microcompartments
9. Researchers find possible new treatment strategies for pancreatic cancer
10. Scripps oceanography researchers discover arctic blooms occurring earlier
11. Nature study: Jefferson researchers unravel proteins elusive role in embryo and disease development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... July 11, 2014--Researchers at the Department of Energy,s ... 100 awards, presented by R&D Magazine in recognition ... "These awards recognize the tremendous value of our ... "Research and development at the National Labs continues ... and pursue the scientific and technological innovations necessary ...
(Date:7/11/2014)... awarded Michael F. Holick, PhD, MD, of Boston University ... Avioli Award. Holick, a professor of medicine, physiology and ... understanding of vitamin D and its role in disease ... the American Society for Bone and Mineral Research (ASBMR) ... It is named for ASBMR,s first president and founding ...
(Date:7/11/2014)... USC Stem Cell scientists have set a "mouse TRAP" ... described by a recent study published in the ... line uses a technique called TRAP to extract cellular ... , Invented by scientists at the Rockefeller Institute for ... tag to the protein-making machinery, or ribosomes, of the ...
Breaking Biology News(10 mins):ORNL wins eight R&D 100s 2ORNL wins eight R&D 100s 3ORNL wins eight R&D 100s 4BUSM's Michael F. Holick receives American Society for Bone and Mineral Research award 2
... United States have autoantibodies, which are proteins made by ... define a condition known as autoimmunity, a study shows. ... of the most common type of autoantibody, known as ... is highest among women, older individuals, and African-Americans. The ...
... estimated to be seven billion and all these mouths ... of fish stocks in our seas fish farming is ... issues about maintaining the health of stock and how ... Central,s open access journal BMC Microbiology demonstrates ...
... evolution of pigmentation patterns on mollusk seashellswhich could ... proved to be a challenging feat for researchers. ... of Pittsburgh and University of California, Berkeley, researchers ... sea snail Conus to generate a ...
Cached Biology News:NIH study shows 32 million Americans have autoantibodies that target their own tissues 2Titanium dioxide film enhances the sun's natural disinfection power 2Breakthrough model reveals evolution of ancient nervous systems through seashell colors 2
(Date:7/11/2014)... 11, 2014 Cayenne Medical, Inc., ... in the soft tissue reconstruction segment, announced the ... for surgeries involving the shoulder and extremities. The ... novel, inserter-controlled deployment method. The unique delivery eliminates ... anchor pull-out, or anchor displacement (also commonly know ...
(Date:7/10/2014)... Boston, Mass. (PRWEB) July 10, 2014 ... , today announced that Alan Swahn, a former vice ... Terascala’s executive team as vice president of marketing. Terascala’s ... from Dell and NetApp create the highest performance and ... has been appointed to guide Terascala’s channel expansion and ...
(Date:7/10/2014)... Calabasas, CA (PRWEB) July 10, 2014 ... academic institutions and professional associations, addressed the challenges of ... & Medical Device Industries” through strategic sourcing. Describing the ... ) with the Supply Chain Management Institute ( SCMI) ... the event on June 24 at the Kroc Institute ...
(Date:7/10/2014)... Research and Markets ( http://www.researchandmarkets.com/research/s3bqj2/photonic ) ... Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module ... to their offering. ... integration traces its roots in the latter half ... integration went unexplored and unfulfilled for several decades ...
Breaking Biology Technology:Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 3Terascala Expands Executive Team 2Terascala Expands Executive Team 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2
... Jan. 28 Tissue Genesis, Inc., an emerging ... American Medical Systems Holdings, Inc. (Nasdaq: AMMD ) announced ... development of adipose (fat)–derived regenerative cells for use in treating ... million over the life of the agreement to obtain ...
... MADRID , Jan. 28 The 2009 BBVA ... to physicist and chemist Richard N. Zare , of ... the University of Maryland , for their independent, fundamental contributions ... of nature,s building blocks and the underlying interactions between them by ...
... , ... , , ... today,that Scopus Custom Data, the underlying source of Scopus.com, the world,s,largest abstract ... citation linkage analysis between scientific,articles and patents. JST, as the funding agency ...
Cached Biology Technology:American Medical Systems and Tissue Genesis Sign $1.1 Million Collaboration Deal 2American Medical Systems and Tissue Genesis Sign $1.1 Million Collaboration Deal 3American Medical Systems and Tissue Genesis Sign $1.1 Million Collaboration Deal 4Zare and Fisher Win the BBVA Foundation Frontiers of Knowledge Award in Basic Sciences for Rendering Molecules Visible and Analyzing Their Collective Behavior 2Zare and Fisher Win the BBVA Foundation Frontiers of Knowledge Award in Basic Sciences for Rendering Molecules Visible and Analyzing Their Collective Behavior 3Zare and Fisher Win the BBVA Foundation Frontiers of Knowledge Award in Basic Sciences for Rendering Molecules Visible and Analyzing Their Collective Behavior 4Zare and Fisher Win the BBVA Foundation Frontiers of Knowledge Award in Basic Sciences for Rendering Molecules Visible and Analyzing Their Collective Behavior 5Zare and Fisher Win the BBVA Foundation Frontiers of Knowledge Award in Basic Sciences for Rendering Molecules Visible and Analyzing Their Collective Behavior 6Zare and Fisher Win the BBVA Foundation Frontiers of Knowledge Award in Basic Sciences for Rendering Molecules Visible and Analyzing Their Collective Behavior 7Japan Science and Technology Agency (JST) Selects Scopus Custom Data for Citation Linkage Analysis Between Scientific Articles and Patents 2Japan Science and Technology Agency (JST) Selects Scopus Custom Data for Citation Linkage Analysis Between Scientific Articles and Patents 3Japan Science and Technology Agency (JST) Selects Scopus Custom Data for Citation Linkage Analysis Between Scientific Articles and Patents 4Japan Science and Technology Agency (JST) Selects Scopus Custom Data for Citation Linkage Analysis Between Scientific Articles and Patents 5Japan Science and Technology Agency (JST) Selects Scopus Custom Data for Citation Linkage Analysis Between Scientific Articles and Patents 6
... 10 ,Yeast extract, 5 ,Sodium chloride, ... ammonium citrate, 0.5 ,IPTG, 0.03 ... autoclavable chromogenic substrate for -galactosidase. The ... generates a black insoluble precipitate. Lac+ ...
S-100 alpha/beta chain (8B10)...
SCCRO (S-17)...
... is a nucleoside antibiotic ... is a potent translational ... and eukaryotic cells. Resistance ... by the products of ...
Biology Products: