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UCLA researchers develop way to strengthen proteins with polymers
Date:5/21/2012

ins to form what is called a protein-polymer conjugate," said Heather Maynard, a UCLA associate professor of chemistry and biochemistry and a member of the CNSI. "We found that the polymers significantly stabilized the protein we used lysozyme better to lyophilization (freeze-drying, in which water is removed from the protein) and to heat than did the protein with no additives."

The research team found that attaching the polymer covalently to the protein that is, forming a protein-polymer conjugate stabilized the protein to lyophilization better than adding the non-conjugated polymer at the same concentration.

The team also found that the polymers stabilized lysozyme significantly better than the currently used excipients trehalose and polyethylene glycol, depending on the stress and conditions used.

The Maynard research group is currently exploring the use of their polymer as a stabilizer by attaching it or adding it to FDAapproved protein therapeutics. In addition, they are investigating the mechanism of how the polymer stabilizes proteins.

The research team included Rock J. Mancini and Juneyoung Lee, both graduate students of chemistry and biochemistry in the Maynard research group.


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Contact: Jennifer Marcus
jmarcus@cnsi.ucla.edu
310-267-4839
University of California - Los Angeles
Source:Eurekalert

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