Navigation Links
UCLA researchers develop way to strengthen proteins with polymers
Date:5/21/2012

Proteins are widely used as drugs insulin for diabetics is the best known example and as reagents in research laboratories, but they react poorly to fluctuations in temperature and are known to degrade in storage.

Because of this instability, proteins must be shipped and stored at regulated temperatures, resulting in increased costs, and sometimes must be discarded because their "active" properties have been lost. Manufacturers of protein drugs will generally add substances known as excipients, like polyethylene glycol, to the proteins to prolong their activity.

In a new study published in the Journal of the American Society of Chemistry (DOI: 10.1021/ja2120234), investigators from the UCLA Department of Chemistry and Biochemistry and the California NanoSystems Institute at UCLA (CNSI) describe how they synthesized polymers to attach to proteins in order to stabilize them during shipping, storage and other activities. The study findings suggest that these polymers could be useful in stabilizing protein formulations.

The polymers consist of a polystyrene backbone and side chains of trehalose, a disaccharide found various plants and animals that can live for long periods with very little or no water. An example many people will recognize is Sea- Monkeys the 'novelty aquarium pet' introduced in 1962. SeaMonkeys can be purchased as kits that contain a white powder; when water is added, the powder becomes small shrimp whose long tails are said to resemble those of monkeys.

Trehalose is known to stabilize proteins when water is removed, and as a result, it is an additive in several protein drug formulations approved by the Food and Drug Administration (FDA) to treat cancer and other conditions.

"Our polymers were synthesized by a controlled radical polymerization technique called reversible addition-fragmentation chain transfer (RAFT) polymerization in order to have end groups that can attach to prote
'/>"/>

Contact: Jennifer Marcus
jmarcus@cnsi.ucla.edu
310-267-4839
University of California - Los Angeles
Source:Eurekalert

Page: 1 2

Related biology news :

1. Tufts Medical Center researchers finds marker in premies saliva predicts readiness to feed by mouth
2. Researchers aim to assemble the tree of life for all 2 million named species
3. Dartmouth researchers are learning how exercise affects the brain
4. Nottingham researchers lead worlds largest study into pre-eclampsia
5. Begin early: Researchers say water with meals may encourage wiser choices
6. Researchers look to relatives for clues in quest to develop sources of bioenergy
7. WSU researchers say genes and vascular risk modify effects of aging on brain and cognition
8. KIT researchers succeed in realizing a new material class
9. Sloppy shipping of human retina leads IU researchers to discover new treatment path for eye disease
10. UCSB researchers find that less is more, for female cowbirds
11. Researchers discover first gene linked to missing spleen in newborns
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/6/2014)... team of Florida State University biologists could lead to ... and survive environmental swings such as droughts or floods. ... the journal The Plant Cell , sheds light ... is organized in a cell and how plants regulate ... and others are turned off. , "If you understand ...
(Date:11/5/2014)... Fidel Santamaria, associate professor of biology in the ... researchers in the nation selected to receive a ... Grant for Exploratory Research (EAGER). The funding supports ... support researchers to create new technology that will ... Santamaria, complex behaviors in neuroscience are broken into ...
(Date:11/4/2014)... nature, the right amount of death at the right ... according to new research that could help in understanding ... stocks. , In a paper in the journal ... researcher and European colleagues conclude that the kind of ... loss of individuals, or mortality, depends on the size ...
Breaking Biology News(10 mins):Maize analysis yields whole new world of genetic science 2UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3When less is more: Death in moderation boosts population density in nature 2
... a portion of Zion National Park in the past ... leading to severe ecological damage, loss of cottonwood trees, ... of environmental degradation, all linked to the decline of ... study to affect a broad range of terrestrial and ...
... Wake Forest University Baptist Medical Center and colleagues at ... multi-year study to identify genes that may contribute to ... in their teens and early adult life who have ... their risk factors for heart disease and stroke sooner ...
... of California, San Diego and Yale University have discovered ... bacterium sprayed on crops by organic farmers to reduce ... in laboratory animals. , Their discovery, detailed in ... the National Academy of Sciences, could pave the way ...
Cached Biology News:Cougar predation key to ecosystem health 2Cougar predation key to ecosystem health 3Cougar predation key to ecosystem health 4Scientists work to identify genes that contribute to early heart attack risk 2Bacterial protein shows promise in treating intestinal parasites 2Bacterial protein shows promise in treating intestinal parasites 3
(Date:11/22/2014)... --   , ... KLOX    Mariano Rodriguez ... bestellt    KLOX ist bestens vorbereitet, ... Behandlungssystems zur Wundheilung zu beginnen    , ... erfreut, die folgenden personellen Veränderungen anzukündigen: ...
(Date:11/21/2014)... 2014 The science of light and ... with more than 200 primary students in a traveling ... University of Otago Physics Department and funded by an ... members of the university’s OSA/SPIE Student Chapter visited six ... giving children from small, rural schools hands-on lessons in ...
(Date:11/21/2014)... November 20, 2014 The ... policy research organization representing leading California academic institutions, ... PwC US today released a report ... sciences industry growth. The trend shows a 4 ... 2015 California Biomedical Industry Report indicates that, ...
(Date:11/21/2014)... Arkansas (PRWEB) November 20, 2014 ... Pinnacle Ozone Solutions, LLC (Pinnacle), and PCI, Inc., ... announced that they have been selected to provide ... of Fayetteville, Arkansas Paul R. Noland Wastewater Treatment. ... BlueInGreen’s patented HyDOZ® gas dissolution technology, ...
Breaking Biology Technology:KLOX Technologies meldet Neubesetzung von Führungspositionen 2KLOX Technologies meldet Neubesetzung von Führungspositionen 3KLOX Technologies meldet Neubesetzung von Führungspositionen 4KLOX Technologies meldet Neubesetzung von Führungspositionen 5Optics and photonics outreach programs share science, spark fascination with light 2Optics and photonics outreach programs share science, spark fascination with light 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 4City of Fayetteville Leads Nation with Innovative Ozone Technology 2City of Fayetteville Leads Nation with Innovative Ozone Technology 3City of Fayetteville Leads Nation with Innovative Ozone Technology 4
... LIUZHOU CITY, Guangxi, China , May ... Board: CNBI), ("China BCT" or the,"Company"), a leading pharmaceutical distributor, ... , China , today,announced results for the first quarter ... First Quarter 2010 Highlights, -- Revenue ...
... ... Sales Revenue" - a webinar focusing on essential internet tools and techniques used by eMarketers ... at 2PM EST. Registration for the event is free. For more information, visit ... ...
... and EMERYVILLE, Calif. , May 20 Bayer ... announced that more than 70 studies evaluating the use of Nexavar® (sorafenib) ... (ASCO) annual meeting in Chicago . , ... "Bayer and Onyx are encouraged by the number and ...
Cached Biology Technology:China BCT Reports First Quarter 2010 Results 2China BCT Reports First Quarter 2010 Results 3China BCT Reports First Quarter 2010 Results 4China BCT Reports First Quarter 2010 Results 5China BCT Reports First Quarter 2010 Results 6China BCT Reports First Quarter 2010 Results 7China BCT Reports First Quarter 2010 Results 8China BCT Reports First Quarter 2010 Results 9China BCT Reports First Quarter 2010 Results 10China BCT Reports First Quarter 2010 Results 11China BCT Reports First Quarter 2010 Results 12China BCT Reports First Quarter 2010 Results 13China BCT Reports First Quarter 2010 Results 14Healthcare Data Solutions Announces New Healthcare eMarketing Webinar 2Healthcare Data Solutions Announces New Healthcare eMarketing Webinar 3Nexavar Data to be Presented at 46th American Society of Clinical Oncology Annual Meeting 2Nexavar Data to be Presented at 46th American Society of Clinical Oncology Annual Meeting 3Nexavar Data to be Presented at 46th American Society of Clinical Oncology Annual Meeting 4Nexavar Data to be Presented at 46th American Society of Clinical Oncology Annual Meeting 5Nexavar Data to be Presented at 46th American Society of Clinical Oncology Annual Meeting 6Nexavar Data to be Presented at 46th American Society of Clinical Oncology Annual Meeting 7Nexavar Data to be Presented at 46th American Society of Clinical Oncology Annual Meeting 8
... used to quantitate double-stranded DNA (dsDNA) in solution, ... With this kit, DNA is stained with Hoechst ... VersaFluor or other fluorometer. The kit quantitates dsDNA ... to 5 micrograms per ml and contains Hoechst ...
... stimulating factors for assays of mouse hematopoietic ... fetal liver. Suitable for the growth ... when added to methylcellulose at a final ... Will also support growth of mouse ...
ImmunoPure Plus Immobilized Protein G, , , , Support: Cross-linked 6%, beaded agarose , Capacity: > 20 mg human IgG/ml of gel ...
...
Biology Products: