Navigation Links
UCLA researchers develop system that finds prostate cancer spread earlier than conventional imaging
Date:9/22/2011

Researchers at UCLA's Jonsson Comprehensive Cancer Center have developed a way to image the spread of a particularly dangerous form of prostate cancer earlier than conventional imaging in use today, which may allow oncologists to find and treat these metastases more quickly and give patients a better chance at survival.

The gene-based imaging system targets prostate cancers that have become resistant to androgen deprivation therapy, an aggressive form of the disease known as castration resistant prostate cancer. Once the hormone treatment is no longer working, the cancer will progress within 12 to 18 months and prognosis becomes grim, said Lily Wu, a professor of molecular and medical pharmacology, a Jonsson Cancer Center researcher and senior author of the study.

"Anytime you can detect cancer earlier, the chances of more effective control of the cancer increase and the outcomes for patients are better," Wu said. "Unfortunately, there is little that can be done to treat castration resistant prostate cancer once it has spread. In our study, we focused on finding ways to image these advanced metastatic prostate cancers accurately. "

The study appeared Sept. 21 in the early online edition of Cancer Research, a peer-reviewed journal of the American Association for Cancer Research.

Wu's team focused on using "control switches" of genes that are active only in castration resistant prostate cancer, and linked these molecular switches to a "reporter" gene that can be easily imaged. The specific switch the team used in this study is the prostate specific enhancing sequence (PSES), an androgen-independent promoter in castration resistant prostate cancer that is more specific to that form of malignancy.

The PSES is derived from the prostate specific antigen and the prostate specific membrane antigen (PMSA) and is given a boost by the two-step transcriptional amplification system, which drives the expression of the i
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles Health Sciences
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Joslin researchers identify pathways leading to activation of good fat
2. Kansas researchers find enriched infant formulas benefit brain and heart
3. Researchers sequence dark matter of life
4. Researchers discover a switch that controls stem cell pluripotency
5. MU researchers unveil new method for detecting lung cancer in Nature article
6. Notre Dame researchers demonstrate antibiotic sensing event central to MSRA antibiotic resistance
7. Researchers uncover a potential new benefit of pure maple syrup on liver health
8. EPA grants help Wayne State researchers stave off Great Lakes environmental invaders
9. UTHealth, BCM researchers find common gene variant associated with aortic dissection
10. Researchers find high levels of toxic PCBs in Indiana Harbor and Ship Canal
11. UH researchers work to develop screening method for superbug
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... in understanding the mysteries of the human genome was ... provide the most detailed comparison yet of how the ... , The research, appearing August 28 in in ... encoded in the three species, genomes is "read out," ... chromosomes. , The results add billions of entries to ...
(Date:8/27/2014)... N.C. -- Duke University researchers have identified a gene ... called OSCA1, encodes a protein in the cell membrane ... adjusts the plant,s water conservation machinery accordingly. , ... associate professor of biology at Duke. , The ... Nature , could make it easier to feed the ...
(Date:8/27/2014)... requires nerve cells to rearrange existing patterns of activity ... patterns, a study of monkeys has found. The scientists ... electrical activity of brain cell networks. The study was ... "We looked into the brain and may have seen ... said Aaron Batista, Ph.D., an assistant professor at the ...
Breaking Biology News(10 mins):Encyclopedia of how genomes function gets much bigger 2Encyclopedia of how genomes function gets much bigger 3Encyclopedia of how genomes function gets much bigger 4Water 'thermostat' could help engineer drought-resistant crops 2Scientists plug into a learning brain 2Scientists plug into a learning brain 3
... abnormality that appears to prevent some men from conceiving ... contraceptive, according to University of Iowa researchers reporting their ... American Journal of Human Genetics . Although ... and have proven very effective for family planning, no ...
... A major effort from within the Aspergillus community ... supplement by the Elsevier journal Fungal Genetics ... provides extensive studies based on the genome analysis ... nidulans. The publication was enabled by Eurofungbase, a ...
... student Alistair Boettiger has amassed a beautiful collection of ... them in his computer. He and George Oster, ... mathematical neuroscientist Bard Ermentrout, have written a computer program ... principles developed to explain how the brain works and ...
Cached Biology News:Gene discovery could lead to male contraceptive 2Mollusks taste memories to build shells 2Mollusks taste memories to build shells 3Mollusks taste memories to build shells 4
(Date:8/27/2014)... DENVER , Aug. 27, 2014   MSC ... and patient safety, today announced the appointment of ... With 28 years of experience preparing companies ... in 2013 as Executive Vice President of Corporate Development ... healthcare performance improvement business , as well as corporate ...
(Date:8/27/2014)... TX (PRWEB) August 27, 2014 The ... and in-depth study on the current state of the ... report provides a basic overview of the industry, including ... and Chinese domestic market analysis are provided with a ... the market. A comparison between the international and Chinese ...
(Date:8/27/2014)... Research and Markets  has announced ... (Biodegradable Polymer, Food & Beverage, Personal Care & ... report to their offering. Lactic ... asymmetrical carbon atom. The main applications of lactic ... beverage, personal care product, and pharmaceutical industries. ...
(Date:8/27/2014)... MADISON, N.J. , Aug. 27, 2014 /PRNewswire/ ... significant potential to help physicians better identify early-stage ... progression and disability, according to a new study ... from Quest Diagnostics (NYSE: DGX ) ... of the 14-3-3eta protein outperformed conventional antibody-serum testing, ...
Breaking Biology Technology:MSC names Mary Beth Loesch President and CEO 2Trifluoroacetic Acid Industry (Asia, Europe, North America, ROW) Analysis Report Now Available at ReportsnReports.com 2Global Lactic Acid (Biodegradable Polymer, Food & Beverage, Personal Care & Pharmaceutical) Market - Trends & Forecasts to 2019 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 3Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 4
... SAN DIEGO, Oct. 4 Orexigen® Therapeutics, Inc. (Nasdaq: ... the treatment of obesity, today announced the schedule of ... taking place at the 28th Annual Scientific Meeting of ... the San Diego Convention Center, October 8-12, 2010.Sunday, October ...
... Pharmaceuticals, Inc. (NASDAQ: OGXI ) announced today that ... Investor Forum on Wednesday, October 6 at 10:30 a.m. PDT ... Live webcasts from this conference will be available through the ... http://ir.oncogenex.com . Webcast replays will be available approximately two hours ...
... RAMAT GAN, Israel, October 4, 2010 ... ... ... are keyed by longUrl, so we need to grab the first one. for (var r in data.results) ...
Cached Biology Technology:Orexigen® Therapeutics Announces Upcoming Data Presentations at the 28th Annual Scientific Meeting of The Obesity Society 2OncoGenex Pharmaceuticals to Present at the 9th Annual BIO Investor Forum 2EarlySense's EverOn(R) Central Display Station (CDS) Receives FDA Clearance 2EarlySense's EverOn(R) Central Display Station (CDS) Receives FDA Clearance 3EarlySense's EverOn(R) Central Display Station (CDS) Receives FDA Clearance 4EarlySense's EverOn(R) Central Display Station (CDS) Receives FDA Clearance 5EarlySense's EverOn(R) Central Display Station (CDS) Receives FDA Clearance 6EarlySense's EverOn(R) Central Display Station (CDS) Receives FDA Clearance 7
... Software enables you to identify over ... can distinguish protein isoforms, protein subsets, ... also visualize peptide-protein associations and relationships ... protein identification and relative protein expression ...
... microscopes offer all of the features of ... Equipped with Koehler illumination, a centerable condenser ... B3 is the workhorse of Motic's range ... the need for re-focusing following a change ...
... Green II RNA gel stain is ... has bright fluorescence when bound to RNA ... ideal for use with either formaldehyde/agarose or ... UV transilluminators. A 500 µL unit size ...
... SYBR Green II RNA gel stain is ... bright fluorescence when bound to RNA and low ... with either formaldehyde/agarose or polyacrylamide gels using laser ... 100 minigels. A 500 µL unit size (S-7564) ...
Biology Products: