Navigation Links
UCLA researchers develop new PET scanning probe that will allowing monitoring of the immune system
Date:6/8/2008

opment of the probe is uniquely suited to UCLA's collaborative strengths. Researchers from the cancer center, the Broad stem cell center and the Crump Institute for Molecular Imaging took part in the study. The PET scanner was invented by UCLA's Michael Phelps, also a co-author on this study.

The work by Witte and his colleagues was prompted by the desire to add to a short list of probes now used in PET scanning and to develop new probes that monitor different molecular functions than the current probes.

"What we wanted to do was to develop new ways to look inside a living organism and gather as much information as we can about the immune system," said Caius Radu, an assistant professor of molecular and medical pharmacology, a Jonsson Cancer Center researcher and the first author of the study. "We wanted to know how cells move from one site in the body to another and find a way to trace them to tumors."

In previous studies, Witte and other UCLA researchers were able to track the immune system as it recognized and responded to cancer. But in those studies, the cells had to be modified with "reporter" genes that sequestered a specifically designed PET probe that allowed scientists to monitor them. The new probe doesn't require modified cells, making it easier and less expensive to use and giving it far broader applications than existing probes. In addition to modeling and measuring the immune system, those applications include stratifying different types of cancers and their response to therapy, defining the level of immune response in both normal and pathological situations and helping to determine whether new drugs prompt an immune response to cancer and other diseases.

"This probe will tell us things about the immune system that existing probes can't," said Radu, who also is a member of the Crump Institute for Molecular Imaging.


'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers observe spontaneous ratcheting of single ribosome molecules
2. At Boston symposium, NARSAD researchers report on genes and family traits
3. Fruits, vegetables and teas may protect smokers from lung cancer, UCLA researchers report
4. 2 University of Illinois researchers named HHMI investigators
5. New family of gecko discovered by researchers from the U of Minnesota and Villanova University
6. Montana State University researchers map iron transport protein
7. Gene mutations in mice mimic human-like sleep disorder, UT Southwestern researchers find
8. UF researchers develop improved gene therapy agent
9. Researchers document rapid, dramatic reverse evolution in the threespine stickleback fish
10. Stowers Institute researchers identify gene linked to vertebral defects in patient populations
11. Researchers discover architecture for fundamental processes of life
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... constantly wages war on the human body. Battles ... stalemate. In pancreatic cancer, this stalemate—known as tumor ... aggressively malignant, a phenomena that is poorly understood. ... the laboratory of Salvatore Torquato, a Professor of ... conditions surrounding tumor dormancy and the switch to ...
(Date:10/16/2014)... tract infections and worldwide claims the lives of ... Ghent University have succeeded in developing a promising ... , Xavier Saelens (VIB/UGent): "We discovered a ... the development of a novel approach to vaccination ... numerous small children and elderly people." , ...
(Date:10/15/2014)... is a non-traditional biophysics textbook and it describes how ... journey of discovery into biological systems and provides an ... It is about how our genes make proteins that ... of cells in an organism. It quantifies the principles ... can be found on both large and small scales. ...
Breaking Biology News(10 mins):Modeling tumor dormancy 2New perspectives for development of an RSV vaccine 2New book about life as seen from physics 2
... On April 15, 2010 , Dr. Stipkala joined a panel ... hosted by the University of South Carolina ,s NanoCenter in ... capitalists from all over the Southeast who are active in the nanotechnology ... Dr. Stipkala and ...
... Bethesda, MD The Genetics Society of America is ... selected for poster awards at the 51st Annual Drosophila ... were selected for first, second and third place awards ... undergraduate. This was the first time that undergraduate student ...
... YORK (April 25, 2010) -- Researchers at the ... Psychiatry at Weill Cornell Medical College discovered that ... behaviors. The genetically altered mice, which behaved much ... disorder (OCD), could help scientists design new therapies ...
Cached Biology News:Dr. Jeremy M. Stipkala, Patent Attorney, Speaks on USC NanoCenter Panel 2Genetics Society of America announces award recipients at 51st Annual Drosophila Conference 2Weill Cornell researchers find that a single gene is responsible for OCD-like behaviors in mice 2Weill Cornell researchers find that a single gene is responsible for OCD-like behaviors in mice 3Weill Cornell researchers find that a single gene is responsible for OCD-like behaviors in mice 4
(Date:10/22/2014)... DUBLIN , Oct. 22, 2014 ... "Organic Electronics Market by Material, by Application, Geography ... report to their offering. Organic electronics, ... a branch of material science which deals with small ... as organic because small molecules and polymers are carbon ...
(Date:10/20/2014)... 2014 Convey Computer , the ... from Iowa State University won first place in the ... Convey HC-2ex, the team’s solution achieved the highest overall ... the second place finisher. , Experts from all segments ... month long challenge, using a variety of design tools, ...
(Date:10/20/2014)... Oct. 20, 2014  GenVec, Inc. (NASDAQ: GNVC ... , Ph.D., from its board of directors effective on October ... 2003, and served as its chairman from June 2006 to ... Nominating and Corporate Governance and Audit Committees of the board.  ... a decade of dedicated service to GenVec, and its stockholders," ...
(Date:10/20/2014)... Local veterinary surgeon, Dr. Tim McCarthy is ... donor stem cells for dogs with osteoarthritis. Dr. McCarthy ... performed clinical stem cell therapy for 7 years. The ... a single injection of donor stem cells into one ... and inflammation in the treated joints. , Candidates ...
Breaking Biology Technology:Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 2Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 3Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3Zola P. Horovitz To Retire From GenVec Board 2Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2
... China, May 15, 2012 BGI, one of ... Roche GS FLX+ System has been successfully installed at its ... existing array of short read sequencing technologies and enhance BGI,s ... developed by 454 Life Sciences, a Roche Company, features the ...
... (Santa Barbara, Calif.) Imagine an LED light with 20 ... that can generate, transmit, and store data 100 times faster ... planet be if we could turn waste heat into electricity, ... more efficient, and more accessible? The (IEE) at ...
... 14, 2012  More than one billion people worldwide have a ... the ability of the lens in the eye to change ... others struggle with trying to read menus and newspapers. Maybe ... this change in vision, which often begins around age 40, ...
Cached Biology Technology:BGI Installs Roche GS FLX+ System to Enhance Long Read Sequencing Capabilities for Genome and Transcriptome Research 2BGI Installs Roche GS FLX+ System to Enhance Long Read Sequencing Capabilities for Genome and Transcriptome Research 3Oracle chairman Jeff Henley makes $50 million gift to UC Santa Barbara 2Oracle chairman Jeff Henley makes $50 million gift to UC Santa Barbara 3Oracle chairman Jeff Henley makes $50 million gift to UC Santa Barbara 4New Daily Disposable Multifocal Contact Lenses from CooperVision Offer Comfort, Performance, Health, and Convenience to Fit Your Life 2New Daily Disposable Multifocal Contact Lenses from CooperVision Offer Comfort, Performance, Health, and Convenience to Fit Your Life 3
Biotin d anti-mouse Tim-1...
Mouse monoclonal [1-N-14] to Adenovirus Type 7 hexon C11 Immunogen: Purified Adenovirus type 7 Specificity: This antibody is specific for Adenovirus type 7 hexon C11....
Request Info...
... is the main excitatory neurotransmitter in the ... considered to act only on the ligand-gated ... that are involved in the fast excitatory ... to regulate enzymes producing second messengers via ...
Biology Products: