Navigation Links
UCLA researchers clarify function of glucose transport molecule
Date:7/3/2008

Researchers at the David Geffen School of Medicine at UCLA have solved the structure of a class of proteins known as sodium glucose co-transporters (SGLTs), which pump glucose into cells. These transport proteins are used in the treatment of chronic diarrhea via oral rehydration therapy, saving the lives of millions of children each year. The solution of the SGLT structure will accelerate development of new drugs designed to treat patients with diabetes and cancer.

Led by Jeff Abramson and Ernest Wright of the UCLA Department of Physiology, the research team produced an "atomic snap shot" of an SGLT protein. Using a specialized technique known as X-ray crystallography, they and their team of post-docs and students generated the first high-resolution, three-dimensional picture of a glucose transport protein. The research is published in today's online edition of the journal Science.

"This was a very challenging study that required innovation at each step of the process," said Abramson. "We literally had to invent new approaches to entice the protein into a crystal and then spent years optimizing these crystals to reach a quality suitable for visualization by X-rays. This would not have been possible without high-throughput protein production and purification capabilities."

A tantalizing observation made during the determination of the glucose transporter structure was the possibility for structural similarities with a previously crystallized neurotransmitter transporter molecule. Exploiting these similarities, along with computer modeling of structural dynamics, the researchers obtained the first atomic-level evidence for the mechanism underlying transport of glucose and neurotransmitters (such as serotonin) into cells. These results provide a fundamental understanding of how membrane proteins function in a dynamic manner.

Pharmaceutical companies already have extensive clinical trials underway to evaluate the use
'/>"/>

Contact: Elaine Schmidt
eschmidt@mednet.ucla.edu
310-794-2272
University of California - Los Angeles
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... 20, 2014  Leading identity analyst firm Acuity Market ... the world,s population will have a chip-based National eID ... . Asia , with its ... for more than 60% of all National eID cards ... -- "The Global National eID Industry Report: ...
(Date:10/18/2014)... patients referred for evaluation of suspected genetic conditions, ... 25 percent, including detection of a number of ... disease, according to a study appearing in ... coincide with the American Society of Human Genetics ... or coding regions of thousands of genes simultaneously ...
(Date:10/17/2014)... Copenhagen have shown for the first time how bacteria ... patients, giving them the opportunity to get tremendous insights ... The study also discovered the bacterial growth in chronic ... or slowed down by the immune cells. The researchers ... helped "suffocate" the bacteria, forcing the bacteria to switch ...
Breaking Biology News(10 mins):Half the World's Population Will Have Chip-Based National Electronic Identity (eID) Cards by 2018 2Whole-exome sequencing shows potential as diagnostic tool 2Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2
... the mechanisms that underlie a pathological increase in the size ... the October 24th issue of the journal Molecular Cell ... managing this extremely common cardiac ailment that often leads to ... heart attacks can lead to a abnormal thickening of the ...
... four times more prevalent in the atmosphere than previously ... Institution of Oceanography at UC San Diego. ... geochemistry professor Ray Weiss made the first atmospheric measurements ... more effective at warming the atmosphere than an equal ...
... antioxidant in green tea may prevent or delay the ... researchers say. Researchers were testing EGCG, green tea,s ... diabetes and primary Sjogren,s syndrome, which damages moisture-producing glands, ... focused on Sjogren,s syndrome, so learning that EGCG also ...
Cached Biology News:Research uncovers new steps on pathway to enlarged heart 2Potent greenhouse gas more prevalent in atmosphere than previously assumed 2Potent greenhouse gas more prevalent in atmosphere than previously assumed 3Green tea may delay onset of type 1 diabetes 2Green tea may delay onset of type 1 diabetes 3
(Date:10/20/2014)... - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced ... $5.8 million and provides a good start to Q4.  The orders ... and one in the Middle East ... levels," said Peter Bruijns , President & CEO. "Total bidding ... than they have been for any complete year since the company ...
(Date:10/20/2014)...  GenVec, Inc. (NASDAQ: GNVC ) today announced ... its board of directors effective on October 24, 2014.   Dr. ... as its chairman from June 2006 to November 2013.  During ... Governance and Audit Committees of the board.  ... dedicated service to GenVec, and its stockholders," said Wayne ...
(Date:10/20/2014)... 20, 2014 OncLive® ... Cancer Center at Thomas Jefferson University has joined ... the Strategic Alliance Partnership program, the Sidney Kimmel ... to raise awareness of the Center’s cutting-edge research ... projects. Clinicians and other health care professionals from ...
(Date:10/20/2014)... Local veterinary surgeon, Dr. Tim McCarthy ... of donor stem cells for dogs with osteoarthritis. Dr. ... has performed clinical stem cell therapy for 7 years. ... if a single injection of donor stem cells into ... pain and inflammation in the treated joints. , ...
Breaking Biology Technology:Zola P. Horovitz To Retire From GenVec Board 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2
... be sitting in piles of cash right now. But ... isnt, hell take the latest version of WorkWises manufacturing ... is a provider of enterprise-wide solutions that help manufacturers ... assets. The company recently announced that more than 100 ...
... Both might be counter-intuitive for Wisconsin technology professionals and ... the success of high-tech industry in Wisconsin, according to ... of San Jose-based Cisco Systems , described his ... successful technology clusters at the Wisconsin Economic Summit ...
... Wisconsins secretary of the Department of Commerce, shares ... development in Wisconsin. , ,This feature is part is ... are appearing on the Wisconsin Technology Network (WTN). Titled, ... discussion and debate that will help to illustrate some ...
Cached Biology Technology:WorkWise Helps Manufacturers Squeeze Bottom Line 2Ciscos John Morgridge Speaks on How Wisconsin can Develop Successful Technology Clusters 2Ciscos John Morgridge Speaks on How Wisconsin can Develop Successful Technology Clusters 3Grow Wisconsin resources for technology development 2Grow Wisconsin resources for technology development 3
... Tracker Intracellular Localization Kit provides a straight ... siRNA, of your design, in an efficient ... experiments. Subcellular localization and functional inhibition of ... introduction of the labeled siRNA into mammalian ...
... The Label IT siRNA Tracker Intracellular Localization ... directly label and deliver siRNA, of your ... for in vitro tracking experiments. Subcellular localization ... can be monitored following introduction of the ...
... is a new product number, ... product number. If showing no ... the old Sigma-Aldrich number (Z71,344-9) ... assistance. ID clarifier: box holds ...
... extracellular matrix (ECM) is an important step ... invasion by adhering to and spreading along ... such as MMP collagenases, dissolve tiny holes ... the blood vessels to allow cancer cells ...
Biology Products: