Navigation Links
UCLA engineers develop new metabolic pathway to more efficiently convert sugars into biofuels
Date:9/30/2013

UCLA chemical engineering researchers have created a new synthetic metabolic pathway for breaking down glucose that could lead to a 50 percent increase in the production of biofuels.

The new pathway is intended to replace the natural metabolic pathway known as glycolysis, a series of chemical reactions that nearly all organisms use to convert sugars into the molecular precursors that cells need. Glycolysis converts four of the six carbon atoms found in glucose into two-carbon molecules known acetyl-CoA, a precursor to biofuels like ethanol and butanol, as well as fatty acids, amino acids and pharmaceuticals. However, the two remaining glucose carbons are lost as carbon dioxide.

Glycolysis is currently used in biorefinies to convert sugars derived from plant biomass into biofuels, but the loss of two carbon atoms for every six that are input is seen as a major gap in the efficiency of the process. The UCLA research team's synthetic glycolytic pathway converts all six glucose carbon atoms into three molecules of acetyl-CoA without losing any as carbon dioxide.

The research is published online Sept. 29 in the peer-reviewed journal Nature.

The principal investigator on the research is James Liao, UCLA's Ralph M. Parsons Foundation Professor of Chemical Engineering and chair of the chemical and biomolecular engineering department. Igor Bogorad, a graduate student in Liao's laboratory, is the lead author.

"This pathway solved one of the most significant limitations in biofuel production and biorefining: losing one-third of carbon from carbohydrate raw materials," Liao said. "This limitation was previously thought to be insurmountable because of the way glycolysis evolved."

This synthetic pathway uses enzymes found in several distinct pathways in nature.

The team first tested and confirmed that the new pathway worked in vitro. Then, they genetically engineered E. coli bacteria to use the synth
'/>"/>

Contact: Matthew Chin
mchin@support.ucla.edu
310-206-0680
University of California - Los Angeles
Source:Eurekalert

Page: 1 2

Related biology news :

1. Stanford engineers monitor heart health using paper-thin flexible skin
2. Natures phenomena might teach Virginia Tech engineers new tricks
3. Cornell engineers solve a biological mystery and boost artificial intelligence
4. Iowa State computer, electrical engineers working to help biologists cope with big data
5. Maintaining Earths sustainability: Scientists, engineers, educators take coordinated approach
6. Nanoengineers can print 3D microstructures in mere seconds
7. WHOI scientists/engineers partner with companies to market revolutionary new instruments
8. Medusa reimagined: Caltech-led team reverse engineers a jellyfish with the ability to swim
9. BYU engineers conceive disc replacement to treat chronic low back pain
10. Civil engineers find savings where the rubber meets the road
11. Engineers use droplet microfluidics to create glucose-sensing microbeads
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... BETHESDA, Md. , April 2, 2015 ... Salt Lake City , the American ... election of five new directors to its Board.  Members ... for the ACMG and for forming and advancing its ... the medical genetics profession. "It,s an eventful ...
(Date:4/1/2015)...   Medisafe ™, the leading global medication management ... and Android smartphones and tablets, announces ... platform to allow patients to track and correlate their ... patients will be able to visualize in real-time how ... such as glucose levels and blood pressure. ...
(Date:3/26/2015)... -- The Granite Club, Canada,s ... today announced it has implemented a state-of-the-art access and ... members and staff, while restricting access to authorized users ... FST,s IMID Access system because it has the perfect ... staff, in addition to unparalleled security," said James ...
Breaking Biology News(10 mins):American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2
... that increase the risk of developing endometriosis, a common ... of this often very painful condition, which has a ... Details of the research, carried out at ... Nuffield Department of Obstetrics & Gynaecology, University of Oxford; ...
... Men with type 1 diabetes may be able ... tissue, say Georgetown University Medical Center (GUMC) researchers who ... Cell Biology 50th annual meeting in Philadelphia. Their laboratory ... human spermatogonial stem cells (SSCs) extracted from testicular tissue ...
... treatment of breast cancer just because a woman is pregnant, ... Breast Group. This suggestion is based on study results ... Loibl presented this data at the 33rd Annual CTRC-AACR San ... the time we started the study in 2003, there was ...
Cached Biology News:Genetic variants linked to increased risk of common gynecological disease 2'Grow your own transplant' may be possible for men with type 1 diabetes 2Unique needs and outcomes of pregnant women with breast cancer identified 2
(Date:5/1/2015)... , May 1, 2015 Pfenex ... engaged in the development of biosimilar therapeutics including ... today that its first quarter 2015 financial results ... before the open of market. At 8:30 am Eastern ... to discuss the financial results and provide a ...
(Date:5/1/2015)... 2015 Investor-Edge has initiated ... (NASDAQ: GENE ), Agilent Technologies Inc. (NYSE: ... TMO ), Sequenom Inc. (NASDAQ: SQNM ... Free research report on Genetic Technologies can be ... 30, 2015, the NASDAQ Composite ended at 4,941.42, ...
(Date:5/1/2015)... RESEARCH TRIANGLE PARK, N.C. , May 1, 2015 /PRNewswire/ ... Roger Jeffs , Ph.D., President and Co-Chief Executive Officer ... the company,s business at the Deutsche Bank 40 th ... . The presentation will take place on Wednesday, ... be accessed via a live webcast on the United Therapeutics ...
(Date:4/30/2015)... DIEGO , April 30, 2015   Tamir ... announced today an update on its Ebola antiviral therapy ... Tamir,s leading candidates, TMR004, is currently being evaluated and ... of the battle against Ebola. During the first quarter ... And Leadership Meeting To Accelerate The Evaluation of Potential ...
Breaking Biology Technology:Pfenex To Report First Quarter 2015 Results and Provide Business Update on Thursday, May 14, 2015 2Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 2Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 3Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 4Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 5Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 2Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 3Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 4
... Overview , ... the separation and purification of a number of biological molecules. For ... A, or a protein may be purified on the basis of ... purifications take place in a chromatographic column with a relatively large ...
... Purpose , Agricultural ... effectively and efficiently using LC/MS/MS. These agricultural compounds are extracted from ... Overview , ... great importance on the identification and quantitation of insecticides and herbicides ...
... Abstract , ... techniques that produce highpurity total RNA from biological sources such as ... or other manual handling, and produce a highly pure product, free ... These new techniques respond to the ...
Cached Biology Technology:Use of ZipTip Pipette Tips for Microscale Affinity Mass Spectrometry 2Use of ZipTip Pipette Tips for Microscale Affinity Mass Spectrometry 3Identification of Insecticides and Herbicides by LC/MS/MS Using the API 2000 LC/MS/MS System 2Total RNA Purification from Cultured Cells Using the ABI PRISM 6700 Automated Nucleic Acid Workstation and Total RNA Lysis Reagents 2Total RNA Purification from Cultured Cells Using the ABI PRISM 6700 Automated Nucleic Acid Workstation and Total RNA Lysis Reagents 3Total RNA Purification from Cultured Cells Using the ABI PRISM 6700 Automated Nucleic Acid Workstation and Total RNA Lysis Reagents 4Total RNA Purification from Cultured Cells Using the ABI PRISM 6700 Automated Nucleic Acid Workstation and Total RNA Lysis Reagents 5Total RNA Purification from Cultured Cells Using the ABI PRISM 6700 Automated Nucleic Acid Workstation and Total RNA Lysis Reagents 6
... product contains 5 ml Dynabeads® ... the monoclonal BerEP4 against the ... cell adhesion molecule). Also available ... 2 x 10e7 MNC in ...
albumin from bovine serum (BSA), tetramethylrhodamine conjugate...
Superior homology search software - in all the flavours of blast, with increased sensitivity and speed...
... Processing mini Tray (3 per pack), ... staining and blot processing.Automated staining of ... proteins and nucleic acid analysis.Prepares blots ... chromogenic detection.Programmable control of protocol, solution, ...
Biology Products: