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UCLA biologists slow the aging process in fruit flies
Date:11/9/2011

m cells, previous research has shown. The biologists also asked what would happen if they used genetic and molecular tools to boost PGC-1 gene expression within only the stem cells and their immediate "daughter" cells.

"Collaborating with a stem cell group at the Salk Institute for Biological Studies, we boosted the gene expression within just the stem- and the immediate daughter-cell types and found that was sufficient to extend the life span of the flies," said Walker, who studies the basic underlying mechanisms of the aging process.

In addition, increasing the fruit fly's version of PGC-1 delays the onset of cellular changes within the intestine, thereby establishing a link between mitochondria, tissue stem cells and aging, the new study shows.

"Many scientists study the diseases of aging, and they tend to do so individually," Walker said. "One group will study Alzheimer's disease, another group will study cardiovascular disease, another will study cancer. We take a different approach. We don't single out any of these specific diseases of old age. We study the aging process itself. Aging is the No. 1 risk factor for most cancers, heart disease, Alzheimer's disease, Parkinson's disease and many others."


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Contact: Stuart Wolpert
swolpert@support.ucla.edu
310-206-0511
University of California - Los Angeles
Source:Eurekalert  

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