Navigation Links
UCLA biologists slow the aging process in fruit flies
Date:11/9/2011

UCLA life scientists have identified a gene that slows the aging process.

The biologists, working with fruit flies, activated a gene called PGC-1, which increases the activity of mitochondria, the tiny power generators in cells that control cell growth and tell cells when to live and die.

"We took this gene and boosted its activity in different cells and tissues of the fly and asked whether this impacts the aging process," said David Walker, an assistant professor of integrative biology and physiology at UCLA and a senior author of the study. "We discovered that when we boost PGC-1 within the fly's digestive tract, the fly lives significantly longer. We also studied neurons, muscle and other tissue types and did not find life extension; this is telling us there is something important about the digestive tract."

The research appears in the current online edition of Cell Metabolism, the leading journal in its field, and will be published in an upcoming print edition. Co-authors are from Walker's laboratory, the Salk Institute for Biological Studies in La Jolla, Calif., and the department of biology at UC San Diego.

"By activating this one gene in this one tissue the intestine the fly lives longer; we slow aging of the intestine, and that has a positive effect on the whole animal," said Walker, a member of UCLA's Molecular Biology Institute. "Our study shows that increasing PGC-1 gene activity in the intestine can slow aging, both at the cellular level and at the level of the whole animal."

The biologists delayed the aging of the flies' intestines and extended their lives by as much as 50 percent.

Fruit flies, or Drosophila melanogaster, have a life span of about two months. They start showing signs of aging after about one month, and they slow down, become less active and die, Walker said. They are a great model for studying aging, he said, because scientists know every one of their genes
'/>"/>

Contact: Stuart Wolpert
swolpert@support.ucla.edu
310-206-0511
University of California - Los Angeles
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Biologists use flies and mice to get to the heart of Down syndrome
2. Do bacteria age? Biologists discover the answer follows simple economics
3. American Society of Plant Biologists supports science outreach by grad students and postdocs
4. NYU biologists use Sinatra-named fly to show how to see the blues -- and the greens
5. FSU biologists fish for reasons behind endangered groupers comeback
6. Pitt biologists find surprising number of unknown viruses in sewage
7. UC San Diego biologists discover genes that repair nerves after injury
8. Biologists discovery may force revision of biology textbooks
9. Team led by IU biologists confirms sunflower domesticated in US, not Mexico
10. Open minded and open access: NeoBiota, a new publishing platform for invasion biologists
11. Plant biologists dissect genetic mechanism enabling plants to overcome environmental challenge
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCLA biologists slow the aging process in fruit flies
(Date:9/15/2014)... digestion to disease resistance. Despite the fact that tropical ... planet, more is known about belly-button bacteria than bacteria ... working on Panama,s Barro Colorado Island discovered that small ... more than 400 different kinds of bacteria. The combined ... different kinds. , Bacteria in tropical forests may also ...
(Date:9/15/2014)... determined that a single group of microorganisms may be ... in the oceans, with implications for the global carbon ... an essential molecule required by most life on this ... group of microorganisms because it is so large and ... in maintaining the brain and nervous systems, as well ...
(Date:9/15/2014)... that reef biodiversity may not provide the level of ... In an international study published today, Professor David Bellwood ... Studies (Coral CoE) says we need to identify and ... In coral reefs, just as in any modern-day society, ... and functioning. , Professor Bellwood says, in many ...
Breaking Biology News(10 mins):Smithsonian scientists discover tropical tree microbiome in Panama 2Researchers discover new producer of crucial vitamin 2Specialized species critical for reefs 2
... are often seen laughing and smiling, but this cheerful ... and seizures. , ,ew research in mice, ... alleviated. , Edwin Weeber, Ph.D., and colleagues reversed ... syndrome by preventing the inhibition of CaMKII, an enzyme ...
... sea levels in the centuries to come? Are we destroying ... oceans on the rise? Can aquaculture be environmentally sustainable? And ... coastal fisheries? , Most importantly, what can governments, industry and ... media are invited to join leading international researchers and government ...
... winner of the 2006 David Horrobin Prize for medical ... Assumption and No Two Alike, the article, "Parental selection: ... hairlessness and skin color" was judged to best embody ... in 2004, is awarded annually and named in honour ...
Cached Biology News:Angelman syndrome deficits rescued in mice 2Angelman syndrome deficits rescued in mice 3Are we killing the world's oceans? 2Why aren't humans furry? Stone-Age moms could be the answer 2
(Date:9/16/2014)...   Synthetic Biologics, Inc. (NYSE MKT: ... and drug programs targeting specific pathogens that cause ... the Company,s Investor Day in New ... syndrome (IBS) program, including its novel, oral product ... the keynote presentation, Mark Pimentel , MD, ...
(Date:9/16/2014)... LOUISVILLE, Ky. , Sept. 16, 2014 /PRNewswire/ ... laboratory technologies and products to hospitals, physician office ... announce that, effective October 1, 2014, it will ... in specified hospital market segments and as a ... in the 48 contiguous United States ...
(Date:9/16/2014)... In preparation for VARTECH 2014, 2FA, Inc., ... focused on authentication and SSO announced today that their ... generate a OTP through the presentation of an RFID ... RFID authentication, 2FA,s solutions have leveraged the existence of ... RFID authentication is broadly deployed in healthcare and other ...
(Date:9/16/2014)... 16, 2014 RENU 28, the world's first ... available for purchase in Australia and New Zealand in ... beginning September 16th. The tour will make stops in Brisbane ... on the 18th, Sydney on the 20th, and Melbourne on ... and New Zealand and to educate people about the new ...
Breaking Biology Technology:Synthetic Biologics' Statin-Class Candidate for Constipation-Predominant Irritable Bowel Syndrome Detailed at Company's Investor Day 2Synthetic Biologics' Statin-Class Candidate for Constipation-Predominant Irritable Bowel Syndrome Detailed at Company's Investor Day 3LABSCO Secures Alliance With Siemens Healthcare Diagnostics 2LABSCO Secures Alliance With Siemens Healthcare Diagnostics 32FA, Inc. Announces RFID-based One-Time Password (OTP) Authentication 2Global Wellness Company Hosts ASEA Australia Tour September 16-22 2
... , Key ... • receptor binding assay • LEADseeker • ... The α 2 -adrenergic receptors are G protein-coupled receptors ... as renal Na + re-absorption, insulin secretion, platelet aggregation, and neurotransmitter release ...
... Key words: NK2 • GPCR ... SPA Imaging Beads , ... a family of small neuropeptides. Members of this family include peptides, substance ... hemokinin-1 (1). Neurokinins are widely distributed throughout the central and peripheral nervous ...
... Key words: formalin-fixed ... degenerate oligonucleotideprimed PCR (DOP-PCR),• Cy3/Cy5-dCTP probe labeling • comparative,genomic ... array CGH , ... Human genomic DNA isolated from formalin-fixed paraffin-embedded (FFPE) tissue ...
Cached Biology Technology:Development of an adrenergic α2a receptor binding assay using the LEADseeker Multimodality Imaging System 2Development of an adrenergic α2a receptor binding assay using the LEADseeker Multimodality Imaging System 3Development of an adrenergic α2a receptor binding assay using the LEADseeker Multimodality Imaging System 4Development of an NK2 neuropeptide receptor binding assay using LEADseeker Multimodality Imaging System 2Development of an NK2 neuropeptide receptor binding assay using LEADseeker Multimodality Imaging System 3Development of an NK2 neuropeptide receptor binding assay using LEADseeker Multimodality Imaging System 4GenomiPhi amplification of FFPE tissue DNA for array CGH 2GenomiPhi amplification of FFPE tissue DNA for array CGH 3GenomiPhi amplification of FFPE tissue DNA for array CGH 4GenomiPhi amplification of FFPE tissue DNA for array CGH 5GenomiPhi amplification of FFPE tissue DNA for array CGH 6GenomiPhi amplification of FFPE tissue DNA for array CGH 7GenomiPhi amplification of FFPE tissue DNA for array CGH 8GenomiPhi amplification of FFPE tissue DNA for array CGH 9GenomiPhi amplification of FFPE tissue DNA for array CGH 10
... custom siRNA service provides the premium quality ... research. Custom siRNAs can be readily ordered ... target sequence, or by providing the sense ... Ambion's Silencer Validated and Silencer Pre-designed siRNAs, ...
... Ambion's custom siRNA service provides the premium ... silencing research. Custom siRNAs can be readily ... base target sequence, or by providing the ... out Ambion's Silencer Validated and ...
Human SDNSF/MCFD2 Biotinylated Affinity Purified PAb...
Recombinant Ovine (Sheep) Prolactin, Ultra Pure...
Biology Products: