Navigation Links
UCLA biologists slow the aging process in fruit flies
Date:11/9/2011

UCLA life scientists have identified a gene that slows the aging process.

The biologists, working with fruit flies, activated a gene called PGC-1, which increases the activity of mitochondria, the tiny power generators in cells that control cell growth and tell cells when to live and die.

"We took this gene and boosted its activity in different cells and tissues of the fly and asked whether this impacts the aging process," said David Walker, an assistant professor of integrative biology and physiology at UCLA and a senior author of the study. "We discovered that when we boost PGC-1 within the fly's digestive tract, the fly lives significantly longer. We also studied neurons, muscle and other tissue types and did not find life extension; this is telling us there is something important about the digestive tract."

The research appears in the current online edition of Cell Metabolism, the leading journal in its field, and will be published in an upcoming print edition. Co-authors are from Walker's laboratory, the Salk Institute for Biological Studies in La Jolla, Calif., and the department of biology at UC San Diego.

"By activating this one gene in this one tissue the intestine the fly lives longer; we slow aging of the intestine, and that has a positive effect on the whole animal," said Walker, a member of UCLA's Molecular Biology Institute. "Our study shows that increasing PGC-1 gene activity in the intestine can slow aging, both at the cellular level and at the level of the whole animal."

The biologists delayed the aging of the flies' intestines and extended their lives by as much as 50 percent.

Fruit flies, or Drosophila melanogaster, have a life span of about two months. They start showing signs of aging after about one month, and they slow down, become less active and die, Walker said. They are a great model for studying aging, he said, because scientists know every one of their genes
'/>"/>

Contact: Stuart Wolpert
swolpert@support.ucla.edu
310-206-0511
University of California - Los Angeles
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Biologists use flies and mice to get to the heart of Down syndrome
2. Do bacteria age? Biologists discover the answer follows simple economics
3. American Society of Plant Biologists supports science outreach by grad students and postdocs
4. NYU biologists use Sinatra-named fly to show how to see the blues -- and the greens
5. FSU biologists fish for reasons behind endangered groupers comeback
6. Pitt biologists find surprising number of unknown viruses in sewage
7. UC San Diego biologists discover genes that repair nerves after injury
8. Biologists discovery may force revision of biology textbooks
9. Team led by IU biologists confirms sunflower domesticated in US, not Mexico
10. Open minded and open access: NeoBiota, a new publishing platform for invasion biologists
11. Plant biologists dissect genetic mechanism enabling plants to overcome environmental challenge
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCLA biologists slow the aging process in fruit flies
(Date:8/21/2014)... to ignore, but they are the ultimate source of ... are increasingly dependent on algae, too, to suck up ... to the bottom of the ocean. Now, by using ... have evidence showing that viruses infecting those algae are ... when all else stays essentially the same, and this ...
(Date:8/21/2014)... Nine researchers from Beth Israel Deaconess Medical Center (BIDMC ... World,s Most Influential Scientific Minds 2014," a comprehensive ... a web resource for science metrics and research performance ... the most influential "are performing and publishing work that ... their science," according to a Thomson Reuters statement. Researchers ...
(Date:8/21/2014)... to Wednesday, Oct. 18-22, 2014 , WHERE: ... Drive, San Diego, CA 92101 , WHAT: ... presentations of the latest research in human genetics. ... featuring high-scoring abstracts on rare genetic variants in ... and treatment for sun sensitivity (Saturday, Oct. 18, ...
Breaking Biology News(10 mins):Viruses take down massive algal blooms, with big implications for climate 2BIDMC researchers named among 'the most influential scientific minds' 2BIDMC researchers named among 'the most influential scientific minds' 3American Society of Human Genetics 2014 Annual Meeting 2
... antibiotic appears to be a safe treatment for stroke and ... is currently the only FDA-approved drug therapy, researchers report. ... and Oregon found the drug well tolerated even at three-and-one-half ... arthritis, according to a research team led by the Medical ...
... flowers to produce pretty petals or sweet scents now ... new types of flowers. DNA analysis of wild evergreen ... of the plant could be derived from hybrids cross-breeds ... the rich biodiversity of the natural world, as it shows ...
... carbon nanotubes (hollow tubes of carbon atoms), MIT chemical ... 100 times more than a regular photovoltaic cell. Such ... energy, potentially allowing much smaller and more powerful solar ... a photovoltaic cell, you could have little spots that ...
Cached Biology News:Antibiotic appears safe for stroke patients and good companion for tPA 2Antibiotic appears safe for stroke patients and good companion for tPA 3Nature's gift for gardening may hold key to biodiversity 2MIT researchers develop a way to funnel solar energy 2MIT researchers develop a way to funnel solar energy 3
(Date:8/21/2014)...  BioSpecifics Technologies Corp. (NASDAQ: BSTC ... collagenase-based products marketed as XIAFLEX ® (collagenase ... XIAPEX ® in the EU, today announced ... Phase 2a study of CCH for the potential ... results showed that all three doses of CCH ...
(Date:8/21/2014)... Institute for Molecular Medicine Finland (FIMM), University of ... novel "man and machine" decision support system for ... described in PLOS One scientific journal ... computer vision algorithms similar to those used in ... the diagnostically most relevant areas. Tablet computers can ...
(Date:8/21/2014)... 21, 2014 2014 Deep ... is a professional and in-depth research report ... provides basic Seaweed Fertilizer information, including Seaweed ... structure as well as industry overview. This ... domestic market as well as global industry ...
(Date:8/21/2014)... Emmetsburg, IA (PRWEB) August 21, 2014 ... Project LIBERTY Opening , The Court of His Majesty ... King will attend the Grand Opening of POET-DSM Advanced ... on Wednesday, Sept. 3. , The King will take ... formal opening activity, scheduled for 11 a.m.-12:20 p.m. and ...
Breaking Biology Technology:BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 2BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 3BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 4BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 5A novel 'man and machine' decision support system makes malaria diagnostics more effective 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 3His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 3
... Commission,s Joint Research Centre (JRC) has just launched ... representative range of 25 different types of reference ... consumer protection and confidence in many innovative applications ... promising technological developments. By enabling a harmonised risk ...
... CANTEL MEDICAL CORP. (NYSE: CMN ), through ... prevention and control business by purchasing the sterilization monitoring ... Colorado, ConFirm is one of the leading providers of ... ConFirm offers both a mail-in service and in-office spore ...
... LONG BRANCH, N.J., Feb. 14, 2011 Pharma ChemOutsourcing ... the first wave of 50 speakers from a diverse ...   "The biotechs all have clinical ... limited capital and human resources demonstrate how they have ...
Cached Biology Technology:Small material, big impact 2Cantel Medical Acquires the Sterilization Monitoring Business of ConFirm Monitoring Systems, Inc. 2Cantel Medical Acquires the Sterilization Monitoring Business of ConFirm Monitoring Systems, Inc. 3Pharma ChemOutsourcing 2011 Unveils First Wave of 50 Biotech Chemist Speakers for September 12-15 Show in New Jersey 2