Navigation Links
UCLA bioengineers discover how particles self-assemble in flowing fluids

From atomic crystals to spiral galaxies, self-assembly is ubiquitous in nature. In biological processes, self-assembly at the molecular level is particularly prevalent.

Phospholipids, for example, will self-assemble into a bilayer to form a cell membrane, and actin, a protein that supports and shapes a cell's structure, continuously self-assembles and disassembles during cell movement.

Bioengineers at the UCLA Henry Samueli School of Engineering and Applied Science have been exploring a unique phenomenon whereby randomly dispersed microparticles self-assemble into a highly organized structure as they flow through microscale channels.

This self-assembly behavior was unexpected, the researchers said, for such a simple system containing only particles, fluid and a conduit through which these elements flow. The particles formed lattice-like structures due to a unique combination of hydrodynamic interactions.

The research, published online today in the journal Proceedings of the National Academy of Sciences, was led by UCLA postdoctoral scholar Wonhee Lee and UCLA assistant professor of bioengineering Dino Di Carlo.

The research team discovered the mechanism that leads to this self-assembly behavior through a series of careful experiments and numerical simulations. They found that continuous disturbance of the fluid induced by each flowing and rotating particle drives neighboring particles away, while migration of particles to localized streams due to the momentum of the fluid acts to stabilize the spacing between particles at a finite distance. In essence, the combination of repulsion and localization leads to an organized structure.

Once they understood the mechanism, the team developed microchannels that allowed for "tuning" of the spatial frequency of particles within an organized particle train. They found that by simply adding short regions of expanded channel width, the particles could be induced to self-assemble into different structures in a controllable and potentially programmable way.

"Programmable control of flowing microscale particles may be important in opening up new capabilities in biomedicine, materials synthesis and computation, similar to how improved control of flowing electrons has enabled a revolution in computing and communication," Di Carlo said.

For example, controlling the positions of microscale bioparticles, such as cells in flowing channels, is important for the operation of blood analysis and counting diagnostic systems. In addition, improving the uniformity of cell concentrations entering the microscale volume of a print head can enable burgeoning fields such as "tissue printing," in which single cells in a polymer ink are sequentially positioned to form a functional tissue architecture, such as the cylindrical lumen of a blood vessel.

More complete control of lattices of particles may also allow tunable manufacturing of optical or acoustic metamaterials that interact uniquely with light and sound waves based on the arrangement of the embedded particles, the researchers said.


Contact: Matthew Chin
University of California - Los Angeles

Related biology news :

1. UC San Diego bioengineers fill holes in science of cellular self-organization
2. New method developed by UC San Diego bioengineers gives regenerative medicine a boost
3. Bioengineers succeed in producing plastic without the use of fossil fuels
4. Penn bioengineers create simulator to test blood platelets in virtual heart attacks
5. Bioengineers provide adult stem cells with simultaneous chemical, electrical and mechanical cues
6. Formula discovered for longer plant life
7. Chemical equator discovery will aid pollution mapping
8. Researchers discover that growing up too fast may mean dying young in honey bees
9. Scientists discover why a mothers high-fat diet contributes to obesity in her children
10. Sirtris review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery
11. Groundbreaking discovery may lead to stronger antibiotics
Post Your Comments:
(Date:11/18/2015)... 18, 2015 --> ... new market report titled  Gesture Recognition Market - Global ... - 2021. According to the report, the global gesture recognition market was ... to reach US$29.1 bn by 2021, at a CAGR ... North America dominated the global gesture recognition ...
(Date:11/16/2015)... Calif. , Nov 16, 2015  Synaptics ... of human interface solutions, today announced expansion of ... TouchView ™ touch controller and display driver ... revolution of smartphones. These new TDDI products add ... TD4100 (HD resolution), TD4302 (WQHD resolution), and TD4322 ...
(Date:11/10/2015)... , Nov. 10, 2015  In this ... the basis of product, type, application, disease ... in this report are consumables, services, software. ... are safety biomarkers, efficacy biomarkers, and validation ... report are diagnostics development, drug discovery and ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... ... November 24, 2015 , ... ... the year and one of the premier annual events for pharmaceutical manufacturing: 2015 ... 8–11 November 2015, where ISPE hosted the largest number of attendees in more ...
(Date:11/24/2015)... 2015 --> ... "Oligonucleotide Synthesis Market by Product & Services (Primer, Probe, ... DNA, RNAi), End-User (Research, Pharmaceutical & Biotech, Diagnostic Labs) ... market is expected to reach USD 1,918.6 Million by ... CAGR of 10.1% during the forecast period. ...
(Date:11/24/2015)... SHPG ) announced today that Jeff Poulton , ... Annual Healthcare Conference in New York City ... (1:30 p.m. GMT). --> SHPG ) announced today that ... Piper Jaffray 27 th Annual Healthcare Conference in ... at 8:30 a.m. EST (1:30 p.m. GMT). --> Shire ...
(Date:11/24/2015)... Nov. 24, 2015 /PRNewswire/ - Aeterna Zentaris Inc. ... that the remaining 11,000 post-share consolidation (or 1,100,000 ... (the "Series B Warrants") subject to the previously ... November 23, 2015, which will result in the ... effect to the issuance of such shares, there ...
Breaking Biology Technology: