Irvine, Calif., July 12, 2011 UC Irvine researchers have found a new approach to the creation of customized therapies for virulent flu strains that resist current antiviral drugs.
Using powerful computer simulations, UCI's Rommie Amaro and Robin Bush created a method to predict how pocket structures on the surface of influenza proteins promoting viral replication can be identified as these proteins evolve, allowing for possible pharmaceutical exploitation.
"Our results can influence the development of new drugs taking advantage of this unique feature," said Amaro, assistant professor of pharmaceutical sciences and computer science. The study appears online in Nature Communications.
The search for effective flu drugs has always been hampered by the influenza virus itself, which mutates from strain to strain, making it difficult to target with a specific pharmaceutical approach.
The most common clinical flu treatments are broad-based and only partially effective. They work by interrupting the action of an enzyme protein in the virus called neuraminidase, which plays a critical role in viral replication.
In 2006, scientists discovered that avian influenza neuraminidase exhibited a distinctive, pocket-shaped feature in the area pinpointed by clinically used drugs. They named it the 150-cavity.
Amaro and Bush, associate professor of ecology & evolutionary biology, conducted research at the San Diego Supercomputer Center and the National Institute for Computational Sciences to learn the conditions under which the pockets form.
They created molecular simulations of flu proteins to predict how these dynamic structures move and change and where and when the 150-cavity pockets will appear on the protein surface. This sequence analysis method could be utilized on evolving flu strains, providing vital information for drug design, Amaro said.
She added: "Having additional antivirals in our tre
'/>"/>
| Contact: Tom Vasich tmvasich@uci.edu 949-824-6455 University of California - Irvine Source:Eurekalert |
Related biology news :
1. Owl study expands understanding of human stereovision
2. Virginia Tech Coal and Energy Center selected for study of CO2 injection into storage reservoirs
3. Large human study links phthalates, BPA and thyroid hormone levels
4. University of Houston researcher an author of multi-institutional genetic study of ovarian cancer
5. Study offers new clues about hereditary spastic paraplegia
6. Study suggests new strategy to prevent infertility, birth defects
7. UTMB-led researchers awarded $7.8 million for Gulf spill study
8. LSUHSC conducts landmark study of mid, long-term health effects of oil exposure
9. Nordic study shows marginally higher but overall low risk of stillbirth in ART children
10. First whole-genome lung cancer study by TGen and Virginia G. Piper Cancer Center set for conference
11. Twin study shows lifestyle, diet can significantly influence course of macular degeneration
| Copyright © 2003-2012 Bio-Medicine. All rights reserved. ABOUT | CONTACT US | DISCLAIMER | PRIVACY POLICY | TERMS AND CONDITIONS |  |