Navigation Links
UCI study finds specific genetic cue for sudden cardiac death syndrome
Date:2/18/2014

Irvine, Calif., Feb. 18, 2014 UC Irvine researchers have found a specific genetic flaw that is connected to sudden death due to heart arrhythmia a leading cause of mortality for adults around the world.

While a number of genes have been linked with arrhythmias, UC Irvine's Geoffrey Abbott and his colleagues discovered that the functional impairment of a gene called KCNE2 underlies a multisystem syndrome that affects both heart rhythm and blood flow and can activate chemical triggers that can cause sudden cardiac death.

"With these findings, we can now explore improved early detection and prevention strategies for people who are at higher risk of sudden cardiac death, such as those with diabetes," said Abbott, a professor of pharmacology and physiology & biophysics in the UC Irvine School of Medicine.

Study results appear in the February issue of Circulation: Cardiovascular Genetics, a publication of the American Heart Association.

Distinct from a heart attack, in which the heart continues to beat but blood flow is blocked, sudden cardiac death occurs when the heart ceases to beat because of the uncontrolled twitching of muscle fibers in its ventricles. Without defibrillation within minutes, this type of event is fatal.

In studies on a mouse model with the KCNE2 gene removed, Abbott and his colleagues had found catalysts for sudden cardiac death including high blood cholesterol, anemia, high blood potassium, an age-related delay in the return to a resting position of the ventricle after contraction and, most surprisingly, diabetes.

Abbott said this link to diabetes and other systemic disturbances is significant because genes such as KCNE2 are better known for directly controlling the electrical signaling that ensures a steady heartbeat. The KCNE2 gene provides instructions for making a protein that regulates the activity of potassium channels, which play a key role in a cell's ability to generate
'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related biology news :

1. U of M study finds fertilization destabilizes global grassland ecosystems
2. Worldwide study finds that fertilizer destabilizes grasslands
3. Study on flu evolution may change textbooks, history books
4. University of Guelph study assesses environmental impact of Ontario corn production
5. Neimark Award winners study statistics, chemistry, plant sciences, astrophysics and linguistics
6. Dartmouth study shows US Southwest irrigation system facing decline after 4 centuries
7. Study: IOC should ban lead shot to help wildlife, water
8. UTMB study examines hospital readmission rates after inpatient rehabilitation
9. TGen study uncovers possible genetic markers in breast cancer that spreads to the brain
10. Study involving twin sisters provides clues for battling aggressive cancers
11. Social or stinky? New study reveals how animal defenses evolve
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... Plants rely on sunlight to make their food, but they ... do. Recently, scientists discovered a group of molecules in plants ... in the Journal of the American Chemical Society , ... plant sunscreens work. , Timothy Zwier and colleagues at Purdue ... to daily can cause serious damage to plant DNA and, ...
(Date:10/29/2014)... all the rage. Thousands of scientists worldwide are conducting ... titanium dioxide nanoparticles from sun creams can get through ... from electronic products are as hazardous for the lungs ... food can get into the blood via the intestinal ... are flowing – and the number of scientific projects ...
(Date:10/29/2014)... bodies decompose, their types and numbers of bugs ... could mean the difference between a closed case ... is using a more than $866,000 U.S. Department ... examine these changing populations. The microbial communities may ... death, gender, race, socioeconomic relations and more, said ...
Breaking Biology News(10 mins):Nanosafety research: The quest for the gold standard 2Nanosafety research: The quest for the gold standard 3MSU partners with Detroit to investigate death scenes 2
... is closely tied to its sexual habits, ecologists have ... such intimate relationships between plants and pollinators, the study ... published online in the British Ecological Society,s journal Functional ... in certain bumblebee species found in the shrinking areas ...
... . Over the past decades climate change ... given rise to a growing scientific interest in the ... dominate our energy map are not only becoming scarce, ... Within the field of renewable energies the scientific community ...
... IMMEDIATE RELEASE Fighting global warming at ... Substituting chicken, fish, or vegetables for red meat ... even more dramatically than buying locally sourced food, ... impacts of food production and distribution in the United ...
Cached Biology News:Ecologists tease out private lives of plants and their pollinators 2More efficient fuel-cells, thanks to a new catalyst 2More efficient fuel-cells, thanks to a new catalyst 3More efficient fuel-cells, thanks to a new catalyst 4American Chemical Society's Weekly PressPac -- April 30, 2008 2American Chemical Society's Weekly PressPac -- April 30, 2008 3American Chemical Society's Weekly PressPac -- April 30, 2008 4American Chemical Society's Weekly PressPac -- April 30, 2008 5American Chemical Society's Weekly PressPac -- April 30, 2008 6American Chemical Society's Weekly PressPac -- April 30, 2008 7American Chemical Society's Weekly PressPac -- April 30, 2008 8
(Date:10/31/2014)... This is a professional and in-depth ... The report provides basic biocides information, including its ... well as industry overview. This research covers the ... well as Global industry analysis covering macroeconomic environment ... Chinese biocides industry covers information on ...
(Date:10/31/2014)... ENVIRON , an international ... that Dr. Harvey Clewell III has rejoined the ... closely with senior professionals in ENVIRON’s Health Sciences ... at The Hamner Institutes for Health Sciences (The ... he is Director, Center for Human Health Assessment. ...
(Date:10/31/2014)... , Oct. 31, 2014  Atlanta-based Intellimedix could ... accompanying the onset of Ebola by suggesting a ... at Georgia Tech,s Center for Computational Systems Biology ... to find alternative uses for existing drugs through ... to aid the bout against Ebola. ...
(Date:10/30/2014)... 30, 2014  Ardelyx, Inc. (NASDAQ: ... cardio-renal, gastrointestinal and metabolic diseases, today announced that ... on Thursday, November 6, 2014. Following the announcement, ... conference call and webcast at 4:30pm ET to ... business update. The live webcast can ...
Breaking Biology Technology:Biocides Market for International & Chinese Regional Development Analysis Now Available at DeepResearchReports.com 2Biocides Market for International & Chinese Regional Development Analysis Now Available at DeepResearchReports.com 3Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 2Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 3Atlanta-Based Intellimedix May Help Solve Ebola With Computer Algorithms 2Ardelyx to Report Third Quarter 2014 Financial Results on November 6, 2014 2
... - Taking more women-owned businesses to the $1 million annual ... perhaps none more important than information technology. , ,That was ... Wisconsin Make Mine a Million program, where women-owned ... extent in their quest to reach the $1 million mark. ...
... Editor's note: Attorney Greg Lynch, a partner with ... on this article with Laura Riske, the firm's director of ... - The United States Department of Energy has ... , ,This funding opportunity is open to applicants with projects ...
... - MailFoundry , a Green Bay anti-spam solution provider, ... 100,000 users and 20 million e-mails per day. , ,The ... this week's Interop exhibit in Las Vegas. , ,The series ... attacks, viruses, and botnets. It comes with MessageIQ 3.0, the ...
Cached Biology Technology:Learning from the big boys: With technology, women urged to go gradual 2Learning from the big boys: With technology, women urged to go gradual 3Wisconsin applicants urged to pursue DOE funding for cellulosic biomass 2
AM100 is an aqueous-based, permanent mounting media designed for use with alkaline phosphatase and immunoperoxidase stained tissue sections....
... first identified as the cellular homolog of the ... Jun D have been shown to be almost ... are involved in dimerization and DNA binding, whereas ... activation, diverge. Antigen: The ...
...
... (phospho Y1007) ( Abpromise for ... Antigen: Synthesized phosphopeptide derived from ... of tyrosine 1007 (K-E-Y P -Y-K). ... 3717 Swiss ...
Biology Products: