Navigation Links
UCI researchers find sea anemone venom-derived compound effective in anti-obesity studies
Date:5/27/2013

stained journey of discovery made over the 30 years that charts the course for expeditious translation to humans who suffer from potentially lethal consequences of metabolic syndrome and autoimmune diseases," said Chandy, professor of physiology & biophysics at UC Irvine and a Kineta scientific advisor. "We evaluated ShK-186 in an obesity model because it has high selectivity for the Kv1.3 target, a favorable pharmacokinetic profile, and meets the qualities of an industry-standard drug."

"These data are quite exciting and strongly support the notion that inhibition of the Kv1.3 channel provides a highly effective method for managing obesity and its associated metabolic abnormalities. The results obtained with ShK-186 are consistent with what one would expect to see with a potent inhibitor of this channel. While additional studies are needed, the potential clinical relevance of this work is enormous, since a significant number of people are afflicted with obesity and its associated complications, and no Kv1.3 inhibitor, as a drug candidate for obesity, has reached the clinic until now," said Dr. Gary V. Desir, professor of medicine at Yale University, and an expert on the Kv1.3 channel's role in renal potassium secretion and glucose metabolism. Dr. Desir was not involved with the study.

"Knowing that ShK-186's unique mechanism of action may have broad utilization across multiple therapeutic disciplines, such as autoimmune diseases and now obesity, further adds to the potential of this compound. This study also shows how medical progress can be made through academic and private sector partnerships," added Charles Magness, Ph.D., President and CEO of Kineta.

According to the World Health Organization (March 2013), obesity worldwide has nearly doubled since 1980. In 2008, more than 200 million men and nearly 300 million women, or 11 percent, were obese. Diabetes is expected to affect roughly 300 million humans by 2030 with an economic cost of
'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. MU researchers develop radioactive nanoparticles that target cancer cells
2. Genetic predictors of postpartum depression uncovered by Hopkins researchers
3. U of M researchers develop model for better testing, targeting of MPNST
4. Widespread but neglected disease a health threat in Africa, Virginia Tech researchers say
5. Penn Medicine researchers identify 4 new genetic risk factors for testicular cancer
6. Non-inherited mutations account for many heart defects, Yale researchers find
7. Researchers discover a missing link in signals contributing to neurodegeneration
8. Researchers use graphene quantum dots to detect humidity and pressure
9. Researchers reveal new more precise method of performing electroconvulsive therapy
10. Researchers calculate the global highways of invasive marine species
11. University of Maryland School of Medicine researchers find potential novel treatment for influenza
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... and the Quebec government have discovered microplastics (in ... of Fisheries and Aquatic Sciences . , The ... industrial cleansers, to which they are commonly added ... buoyancy, they may readily pass through sewage treatment ... the world,s oceans, but have only recently been ...
(Date:9/18/2014)... ability to acquire and creatively manipulate spoken language is ... the past 6 million years of human evolution to ... the best candidate gene we now have," says Wolfgang ... In his efforts to understand the molecular biological basis ... forward. The results of his latest study, undertaken in ...
(Date:9/18/2014)... 2014Many Americans across racial and ethnic groups describe ... on their day-to-day life, more so than other ... speech (57% of African-Americans, 49% of non-Hispanic whites, ... asked which disease or ailment is the worst ... among African-Americans followed by AIDS/HIV. Hispanics and ...
Breaking Biology News(10 mins):Microplastic pollution discovered in St. Lawrence River sediments 2Language evolution: Quicker on the uptake 2Language evolution: Quicker on the uptake 3Americans rate losing eyesight as having greatest impact on their lives 2Americans rate losing eyesight as having greatest impact on their lives 3
... A current controversy raging in evolutionary biology is ... many genes, each of relatively small effect, or just ... published in Molecular Ecology strongly supports the ... from the Department of Biology and the Redpath Museum, ...
... Robot squirrels from the University of California, Davis, ... a research project on the interaction between squirrels and ... how squirrels signal to snakes with heat and tail ... University and UC Davis aim to learn more about ...
... April 3, 2012 A team led by scientists ... prevent infection from widely differing strains of hepatitis C virus ... very high rate of mutation normally helps it to evade ... to sites on the viral envelope that seldom mutate. One ...
Cached Biology News:Robosquirrels versus rattlesnakes 2Robosquirrels versus rattlesnakes 3Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus 2Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus 3Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus 4
(Date:9/18/2014)... MA (PRWEB) September 18, 2014 ... Molecule Sequencing (tSMS™) technology, announced today the closing ... of investment, led by Genomic Diagnostic Technologies, will ... and diagnostic applications. , Founded in March 2013 ... and Bioinformatics Analyst at Helicos BioSciences, SeqLL has ...
(Date:9/18/2014)... Artificial sweeteners, promoted as aids to weight loss and ... intolerance and metabolic disease; and they do it in ... of the gut microbiota the substantial population of ... of experiments in mice and humans, were published today ... Eran Elinav of the Weizmann Institute,s Immunology Department, who ...
(Date:9/18/2014)... The quest for the ultimate memory device for computing ... at The City College of New York led by ... exhibit both magnetic and ferroelectric properties. , Combining both ... can occur between them and for the devices that ... Combining these two properties in a single material, however, ...
(Date:9/18/2014)... September 18, 2014 September 24 marks ... MX. ASEA is the manufacturer of the world's first ... care product, RENU28. , The Mexico City event ... Duvan Botero, and ASEA Field Leader Shawn Catmull from ... PhD in Atomic/Medical Physics from the University of Utah ...
Breaking Biology Technology:SeqLL Closes Series-A Funding Round for Expansion of Single Molecule Sequencing 2Gut bacteria, artificial sweeteners and glucose intolerance 2Gut bacteria, artificial sweeteners and glucose intolerance 3Oxides discovered by CCNY team could advance memory devices 2Announcing the ASEA Mexico Grand Opening Tour Beginning September 18th 2
... , Strategic Examination and Consolidation of Services Recommended ... 27 Little uniformity exists in the structure or functions of ... to Clinical Trials Offices: What,s New in Research Administration?, ... (AAHC). Emerging centralized clinical trial offices (CTOs) are among the ...
... , , ATLANTA, Aug. 27 ... million extension of its Series C financing which was originally completed in ... $5 million in Series C preferred stock received warrants for an additional ... have up to 30 days from the delivery of Phase III top-line ...
... , , , ... ATLANTA, Aug. 27 Airo, recognized maker of the ... Safe handset is available for delivery Q4 of 2009. Airo ... in potentially explosive environments like Petroleum, Chemicals, Fertilizer, Coal, Propane, ...
Cached Biology Technology:Clinical Trials Offices Changing Academic Health Center Research Infrastructure 2Alimera Sciences Closes $5 Million in Extended Series C Financing 2Airo Wireless Announces the Release of the Intrinsically Safe A25is Cell Phone/PDA 2
... Polynucleotide Kinase catalyzes the transfer ... to the 5-terminus of polynucleotides ... 5-hydroxyl group. The enzyme, purified ... be used to phosphorylate RNA, ...
... Freezers for IVF are designed for human ... ease of setup and operation, and convenience. ... are continuously displayed on the control panel. ... are printed by way of the thermal ...
... adamanteus venom Description: Phosphodiesterase I ... in studying nucleic acid structure ... hydrolyzes 5'-mononucleotides from 3'-hydroxy-terminated ribo-oligonucleotides ... I cleaves ADP-ribosylated proteins at ...
... Life Science Rotarods are used to assess the ... fatigue resistance on mice and rats using one ... user friendly; the animals are placed on textured ... onto the individual sensing platforms below, its test ...
Biology Products: