Navigation Links
UCI researchers develop world's first plastic antibodies
Date:6/21/2010

Irvine, Calif., June 21, 2010 UC Irvine researchers have developed the first "plastic antibodies" successfully employed in live organisms stopping the spread of bee venom through the bloodstream of mice.

Tiny polymeric particles just 1/50,000th the width of a human hair were designed to match and encase melittin, a peptide in bee venom that causes cells to rupture, releasing their contents. Large quantities of melittin can lead to organ failure and death.

The polymer nanoparticles were prepared by "molecular imprinting" a technique similar to plaster casting: UCI chemistry professor Kenneth Shea and project scientist Yu Hoshino linked melittin with small molecules called monomers, solidifying the two into a network of long polymer chains. After the plastic hardened, they removed the melittin, leaving nanoparticles with minuscule melittin-shaped holes.

When injected into mice given high doses of melittin, these precisely imprinted nanoparticles enveloped the matching melittin molecules, "capturing" them before they could disperse and wreak havoc greatly reducing deaths among the rodents.

"Never before have synthetic antibodies been shown to effectively function in the bloodstream of living animals," Shea says. "This technique could be utilized to make plastic nanoparticles designed to fight more lethal toxins and pathogens."

Takashi Kodama of Stanford University and Hiroyuki Koide, Takeo Urakami, Hiroaki Kanazawa and Naoto Oku of Japan's University of Shizuoka also contributed to the study, published recently in the Journal of the American Chemical Society.

Unlike natural antibodies produced by live organisms and harvested for medical use, synthetic antibodies can be created in laboratories at a lower cost and have a longer shelf life.

"The bloodstream includes a sea of competing molecules such as proteins, peptides and cells and presents considerable challenges for the design of nanoparticles," Shea says. "The success of this experiment demonstrates that these challenges can be overcome."


'/>"/>

Contact: Laura Rico
lrico@uci.edu
949-824-9055
University of California - Irvine
Source:Eurekalert

Related biology news :

1. Little is understood about alcohols effect on fetal development, Georgetown researchers say
2. Researchers identify a fundamental process in lysosomal function and protein degradation
3. High-yield agriculture slows pace of global warming, say Stanford researchers
4. Mass. General researchers develop functional, transplantable rat liver grafts
5. OU researchers find way to prevent blindness in research model for retinitis pigmentosa
6. Texas A&M veterinary researchers achieve cloning first
7. Researchers discover mechanism that limits scar formation
8. Researchers identify gene linked to hereditary incontinence
9. UCLA stem cell researchers uncover previously unknown patterns in DNA methylation
10. Lasers help researchers predict birds preferred habitat
11. Researchers find gene linked to birth defects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2017)... Feb. 2, 2017   TapImmune, Inc. ... company specializing in the development of innovative peptide ... of cancer and metastatic disease, announced today it ... manufacturing of a second clinical lot of TPIV ... receptor alpha. The manufactured vaccine product will be ...
(Date:2/1/2017)... Massachusetts , February 1, 2017 IDTechEx ... events on emerging technology, announces the availability of a new report, ... Continue Reading ... ... in industrial and collaborative robots. Source: IDTechEx Report "Sensors for Robotics: ...
(Date:1/26/2017)... PANAMA CITY , Jan. 26, 2017  Crossmatch, ... today unveiled a new solution aimed at combatting fraud, ... The solution was introduced at the Action on Disaster ... a key meeting point for UN agencies and foreign ... Fraud, waste and abuse are a largely ...
Breaking Biology News(10 mins):
(Date:2/24/2017)... ... February 24, 2017 , ... Delpor, Inc. (Delpor), a ... from the National Institute of Mental Health (NIMH) for the further advancement of the ... PROZOR technology and is expected to deliver therapeutic levels of olanzapine for a ...
(Date:2/24/2017)... SAN FRANCISCO , Feb. 24, 2017 ... that is developing a new category of therapeutics, announced ... trial of SB-030 in peripheral artery disease. The trial ... locally administered single-use therapeutic, in the reduction of restenosis ... reached this critical development milestone for SB-030," said ...
(Date:2/24/2017)... China Biologic Products, Inc. (NASDAQ: CBPO) ("China Biologic" ... in China, today announced its financial results for the fourth ... Quarter 2016 Financial Highlights Total sales ... RMB terms, or increased by 13.6% in USD terms to ... 2015. Gross profit increased by 13.3% to ...
(Date:2/23/2017)... Financial Highlights (in ... Months Ended December 31,Twelve Months Ended December 31,20162015% ... $           300$     ... Revenue 3539(10)%9498(4)%Kuvan Net Product Revenue ... 756025%297303(2)%Vimizim Net Product Revenue ...
Breaking Biology Technology: