Navigation Links
UCI research turns the corner on autism
Date:1/15/2013

Irvine, Calif. With $14 million from the William & Nancy Thompson Family Foundation and the Children & Families Commission of Orange County, UC Irvine is helping lead the charge against a disorder that affects about 1 in 88 children in the U.S. autism.

The funding created the Center for Autism & Neurodevelopmental Disorders of Southern California, which will provide unparalleled access to assessment, diagnosis, care coordination, family support and education for children, teens and young adults.

Along with facilitating this continuum of care, the generous funding will augment an aggressive UC Irvine research campaign to find new treatments that is affiliated with the new center.

"In addition to all that the Center for Autism & Neurodevelopmental Disorders of Southern California will offer, we must stand behind world-class research," says William Thompson, chairman of the William & Nancy Thompson Family Foundation. "This is taking place right now at UC Irvine. Real breakthroughs must start with research that is directed toward novel treatment approaches, and the research team at UC Irvine is distinctively set up to do this. These efforts walk hand in hand with our clinical, educational and advocacy efforts."

Under the leadership of Dr. J. Jay Gargus, professor of physiology & biophysics and pediatrics, the Center for Autism Research & Treatment will launch an innovative drug discovery effort uniting multidisciplinary campus scientists in a common purpose: to develop an effective pharmaceutical therapy for the core deficits of autism.

"UC Irvine has world-class molecular geneticists, biophysicists, neurobiologists, behaviorists, pharmacologists and clinical researchers, many of whom are already engaged in the study of autism and are excited by the opportunity to work together in an integrated program," says Gargus, a nationally recognized metabolic/genetic specialist.

"CART presents a distinctive chance to have a transformational and lasting impact on autism worldwide because of our focus on how molecular, cellular and brain functions are altered and how drugs affect each level. We are confident that the program and its goals are feasible because all of the necessary pieces are already in place at UC Irvine."

The center's role is particularly important today, he says, because major pharmaceutical companies have mostly neglected autism, and breakthroughs in decoding the human genome are now providing researchers an unprecedented opportunity to understand the innermost workings of autism.

More than a decade ago, it was discovered that cancer is a genetic disease, making the defective genes a target of drug discovery campaigns and resulting in the first round of cancer drugs specific to the molecular lesion. Thus began an optimistic new era of cancer treatments.

Gargus thinks autism research is at a point where it can begin duplicating the trajectory of cancer research. "It is now clear that most autism, like cancer, has a genetic basis and that while rare forms of both are caused by mutations in single genes, many defective genes in a pathway generally need to work together to produce disease," he says.

By determining the mechanisms by which malfunctioning genes affect the common neural pathways linked to autism, Gargus believes, it will be possible to design or repurpose existing drugs to normalize the function of those channels. Like cancer therapy, this may well require a synergistic cocktail of drugs that act on distinct but interacting targets.

Three separate drug discovery efforts by UC Irvine neuroscientists involving these neural pathways are being integrated into CART.

Pharmacology professor Kelvin Gee is testing compounds that stabilize the firing rate of brain cells; psychiatry & human behavior professor Gary Lynch is using molecules called ampakines to increase growth factors in brain cells that allow for normal signaling; and Daniele Piomelli, the Louise Turner Arnold Chair in the

Neurosciences, is finding that boosting natural, marijuana-like chemicals in the brain can improve transmission between neurons.

While not originally focused specifically on autism, their work on these compounds addresses biological machinery implicated in the disorder.

"We're approaching this from different points of view to see what can work," says Gee, who has also created the basis of a treatment for fragile X syndrome a form of autism that is currently undergoing clinical trial. "The more disciplines you can get under one roof, the more lightbulbs you get to turn on. I think it's great."

"We're really raising the bar high," Lynch adds.

Because these compounds have been found effective in rodent models, and some have already been found safe for people, Gargus notes, they're much closer to reaching early-stage testing in human patients.

"We have amazing pieces of the puzzle coming together here," he says. "UC Irvine is truly distinctive in this aggressive push to a cure."


'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Related biology news :

1. Chronic disease research awarded funding
2. Ben-Gurion U. establishes stem cell research fund in honor of inventor Jordan Baruch
3. Researchers create flexible, nanoscale bed of nails for possible drug delivery
4. New research network for multiple sclerosis research
5. F1000Research articles will be listed in PubMed, and deposited in PubMed Central
6. AgriLife Research gets grant to crack biofuel production waste issue
7. Researchers identify a new gene with a key role in obesity and diabetes
8. GW researchers find variation in foot strike patterns in predominantly barefoot runners
9. After decades of research, scientists unlock how insulin interacts with cells
10. Mathematics and weather and climate research
11. KAIST and Saudi Aramco agreed to establish a joint CO2 research center in Korea
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/21/2016)... VANCOUVER, British Columbia , June 21, 2016 ... been appointed to the new role of principal ... has been named the director of customer development. ... , NuData,s chief technical officer. The moves reflect ... development teams in response to high customer demand ...
(Date:6/16/2016)... 2016 The global ... reach USD 1.83 billion by 2024, according to ... Technological proliferation and increasing demand in commercial buildings, ... drive the market growth.      (Logo: ... development of advanced multimodal techniques for biometric authentication ...
(Date:6/9/2016)... control systems is proud to announce the introduction of fingerprint attendance control software, allowing ... are actually signing in, and to even control the opening of doors. ... ... ... Photo - http://photos.prnewswire.com/prnh/20160609/377487 ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 A person commits ... the crime scene to track the criminal down. ... U.S. Food and Drug Administration (FDA) uses DNA evidence to ... Sound far-fetched? It,s not. The FDA has ... to support investigations of foodborne illnesses. Put as simply as ...
(Date:6/23/2016)... FRANCISCO , June 23, 2016   EpiBiome ... has secured $1 million in debt financing from Silicon ... ramp up automation and to advance its drug development ... its new facility. "SVB has been an ... beyond the services a traditional bank would provide," said ...
(Date:6/23/2016)... Calif. , June 23, 2016  Blueprint Bio, ... biological discoveries to the medical community, has closed its ... Matthew Nunez . "We have received ... with the capital we need to meet our current ... essentially provide us the runway to complete validation on ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... line of intelligent tools designed, tuned and optimized exclusively for Okuma CNC machining ... Chicago. The result of a collaboration among several companies with expertise in toolholding, ...
Breaking Biology Technology: