Navigation Links
UCI neuroscientists create fiber-optic method of arresting epileptic seizures
Date:1/24/2013

Irvine, Calif., Jan. 24, 2013 UC Irvine neuroscientists have developed a way to stop epileptic seizures with fiber-optic light signals, heralding a novel opportunity to treat the most severe manifestations of the brain disorder.

Using a mouse model of temporal lobe epilepsy, Ivan Soltesz, Chancellor's Professor and chair of anatomy & neurobiology, and colleagues created an EEG-based computer system that activates hair-thin optical strands implanted in the brain when it detects a real-time seizure.

These fibers subsequently "turn on" specially expressed, light-sensitive proteins called opsins, which can either stimulate or inhibit specific neurons in select brain regions during seizures, depending on the type of opsin.

The researchers found that this process was able to arrest ongoing electrical seizure activity and reduce the incidence of severe "tonic-clonic" events.

"This approach is useful for understanding how seizures occur and how they can be stopped experimentally," Soltesz said. "In addition, clinical efforts that affect a minimum number of cells and only at the time of a seizure may someday overcome many of the side effects and limitations of currently available treatment options."

Study results appear online in Nature Communications.

More than 3 million Americans suffer from epilepsy, a condition of recurrent spontaneous seizures that occur unpredictably, often cause changes in consciousness, and can preclude normal activities such as driving and working. In at least 40 percent of patients, seizures cannot be controlled with existing drugs, and even in those whose seizures are well controlled, the treatments can have major cognitive side effects.

Although the study was carried out in mice, not humans, Soltesz said the work could lead to a better alternative to the currently available electrical stimulation devices.


'/>"/>
Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1

Related biology news :

1. Neuroscientists prove ultrasound can be tweaked to stimulate different sensations
2. UT Dallas researchers awarded $4.3 million to create next-generation technologies
3. Researchers create flexible, nanoscale bed of nails for possible drug delivery
4. Study quantifies the size of holes antibacterials create in cell walls to kill bacteria
5. Powerful enzymes create ethanol from agricultural harvest waste
6. Even in same vineyard, different microbes may create variations in wine grapes
7. Protein creates paths for growing nerve cells
8. New geometries: Researchers create new shapes of artificial microcompartments
9. Rice, Texas Childrens team creates biocompatible patch to heal infants with birth defects
10. Conservationists to create blueprint for saving Malaysias elephants
11. Cells from skin create model of blinding eye disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ) has announced the ... Button Synaptics Fingerprint Sensor Technology Analysis" report to ... Based on a totally different sensing technology ... time a fingerprint sensor in its product. ...
(Date:12/17/2014)... 16, 2014 Valencell, a leader in performance biometric ... to industry leaders such as Intel, Jabra, Atlas, and ... wearable products. These products will be showcased at CES ... Vegas . "Our partners choose ...
(Date:12/15/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/87pph8/global_facial ) ... Recognition Market 2015-2019" report to their offering. ... recognition is a technology used for the identification of ... of a person such as nose, jaw edges, mouth, ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3
... Jan. 24 edition of PLOS Pathogens , Saint Louis ... and the University of Pittsburgh report a breakthrough in the ... the virus. Researchers were able to measure and then block ... taking advantage of known similarities with another major pathogen, HIV. ...
... The Federation of American Societies for Experimental Biology ... Science Research Conference (SRC): Neural Mechanisms in Cardiovascular ... Neural Mechanisms in Cardiovascular Regulation, is an important ... neural mechanisms that regulate normal cardiovascular function, and ...
... MD The Federation of American Societies for ... for the Science Research Conference (SRC): Matricellular Proteins ... cells and their surrounding extracellular matrix (ECM) are ... cell and tissue organization in all metazoan organisms. ...
Cached Biology News:In a fight to the finish, Saint Louis University research aims knockout punch at hepatitis B 2In a fight to the finish, Saint Louis University research aims knockout punch at hepatitis B 3In a fight to the finish, Saint Louis University research aims knockout punch at hepatitis B 4In a fight to the finish, Saint Louis University research aims knockout punch at hepatitis B 5FASEB SRC announces conference: Matricellular Proteins in Development, Health, and Disease 2
(Date:1/22/2015)... Cambridge Semantics, the leading provider of smart ... 2014 was a record-breaking year across the board for the ... Smart Data Platform and our Smart Data solutions, our customers ... data which led to record growth for the company in ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Pipette.com has ... to their comprehensive portfolio of Eppendorf products. , ... to purchase a Centrifuge 5424/5424 R and receive the ... either Eppendorf Research plus or Eppendorf Reference 2 ...
(Date:1/22/2015)... Selexis SA, a serial innovation company with ... used for drug discovery to commercial manufacturing, announced today ... Next-Generation Sequencing (NGS) data packages. The NGS analysis ... ensuring the integrity of the gene, validation of the ...
(Date:1/22/2015)... 2015  Varian Medical Systems (NYSE: VAR ), world ... its commitment to sustainability with inclusion on a prestigious list ... ranked healthcare equipment company among the Corporate Knights Global 100 ... Forum at Davos, Switzerland . ...
Breaking Biology Technology:Cambridge Semantics Announces Record Results for 2014 2Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Varian Honored Among World's 100 Most Sustainable Corporations 2
... they didn't tell Jeanne Moreno when she joined her ... ago. Under the circumstances, she's just fine with that. ... to join a large, global business organization and find ... and obsolete business applications, but compounding the challenge were ...
... : This is the third of a three-part series ... - Will members of the so-called Xbox ... technology as they are in consuming it? , ,Judging by ... schools and institutions of higher learning, there may be more ...
... The past is a source ... , S. Ambrose (1936-2002) Ernest Mueller ... medical, forensic, museum and other archival collections represent,a rich source of ... decades of work by experts in the field. While the majority ...
Cached Biology Technology:CIO Leadership Series: Snap-On's Moreno offers lessons in IT transformation 2CIO Leadership Series: Snap-On's Moreno offers lessons in IT transformation 3CIO Leadership Series: Snap-On's Moreno offers lessons in IT transformation 4CIO Leadership Series: Snap-On's Moreno offers lessons in IT transformation 5While schools combat low tech enrollment, are businesses contributing to IT workforce woes? 2While schools combat low tech enrollment, are businesses contributing to IT workforce woes? 3While schools combat low tech enrollment, are businesses contributing to IT workforce woes? 4While schools combat low tech enrollment, are businesses contributing to IT workforce woes? 5While schools combat low tech enrollment, are businesses contributing to IT workforce woes? 6While schools combat low tech enrollment, are businesses contributing to IT workforce woes? 7Genomic Analysis of Formalin-Fixed Paraffin Embedded (FFPE) Tissues through the use of Whole Genome Amplification (WGA) 2Genomic Analysis of Formalin-Fixed Paraffin Embedded (FFPE) Tissues through the use of Whole Genome Amplification (WGA) 3Genomic Analysis of Formalin-Fixed Paraffin Embedded (FFPE) Tissues through the use of Whole Genome Amplification (WGA) 4Genomic Analysis of Formalin-Fixed Paraffin Embedded (FFPE) Tissues through the use of Whole Genome Amplification (WGA) 5Genomic Analysis of Formalin-Fixed Paraffin Embedded (FFPE) Tissues through the use of Whole Genome Amplification (WGA) 6Genomic Analysis of Formalin-Fixed Paraffin Embedded (FFPE) Tissues through the use of Whole Genome Amplification (WGA) 7
IMAGEQUANT 300 WKSTN, 1 EA. Category: ImageQuant CCD Imagers....
PAb to Hu-IFN-Alpha/Beta R2 [(IFNAR2) CD118], Rabbit Serum, neutralizing Binds to but does not neutralize human interferon alpha/beta receptor...
IMAGEQUANT 400 IQTL, 1 EA. Category: ImageQuant CCD Imagers....
APO-BrdU™ TUNEL Assay Kit *with Alexa Fluor® 488 anti-BrdU* *60 assays*...
Biology Products: