Navigation Links
UCI neuroscientists create fiber-optic method of arresting epileptic seizures
Date:1/24/2013

Irvine, Calif., Jan. 24, 2013 UC Irvine neuroscientists have developed a way to stop epileptic seizures with fiber-optic light signals, heralding a novel opportunity to treat the most severe manifestations of the brain disorder.

Using a mouse model of temporal lobe epilepsy, Ivan Soltesz, Chancellor's Professor and chair of anatomy & neurobiology, and colleagues created an EEG-based computer system that activates hair-thin optical strands implanted in the brain when it detects a real-time seizure.

These fibers subsequently "turn on" specially expressed, light-sensitive proteins called opsins, which can either stimulate or inhibit specific neurons in select brain regions during seizures, depending on the type of opsin.

The researchers found that this process was able to arrest ongoing electrical seizure activity and reduce the incidence of severe "tonic-clonic" events.

"This approach is useful for understanding how seizures occur and how they can be stopped experimentally," Soltesz said. "In addition, clinical efforts that affect a minimum number of cells and only at the time of a seizure may someday overcome many of the side effects and limitations of currently available treatment options."

Study results appear online in Nature Communications.

More than 3 million Americans suffer from epilepsy, a condition of recurrent spontaneous seizures that occur unpredictably, often cause changes in consciousness, and can preclude normal activities such as driving and working. In at least 40 percent of patients, seizures cannot be controlled with existing drugs, and even in those whose seizures are well controlled, the treatments can have major cognitive side effects.

Although the study was carried out in mice, not humans, Soltesz said the work could lead to a better alternative to the currently available electrical stimulation devices.


'/>"/>
Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1

Related biology news :

1. Neuroscientists prove ultrasound can be tweaked to stimulate different sensations
2. UT Dallas researchers awarded $4.3 million to create next-generation technologies
3. Researchers create flexible, nanoscale bed of nails for possible drug delivery
4. Study quantifies the size of holes antibacterials create in cell walls to kill bacteria
5. Powerful enzymes create ethanol from agricultural harvest waste
6. Even in same vineyard, different microbes may create variations in wine grapes
7. Protein creates paths for growing nerve cells
8. New geometries: Researchers create new shapes of artificial microcompartments
9. Rice, Texas Childrens team creates biocompatible patch to heal infants with birth defects
10. Conservationists to create blueprint for saving Malaysias elephants
11. Cells from skin create model of blinding eye disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/11/2017)... Jan. 11, 2017 Intoxalock, a leading ignition ... release of its patent-pending calibration device. With this new ... calibrations, securely upload data logs and process repairs at ... "Fighting drunk driving through the application of ... at large, but also for the customer who can ...
(Date:1/6/2017)... -- Delta ID Inc., a leader in consumer-grade iris scanning ... CES® 2017. Delta ID has collaborated with Gentex Corporation ... of iris scanning as a secure, reliable and convenient ... car, and as a way to elevate the security ... ID and Gentex will demonstrate (booth #7326 LVCC) a ...
(Date:12/22/2016)... -- As part of its longstanding mission to improve genetic literacy ... released its latest children,s book, titled The One ... topics of inheritance and variation of traits that are part ... school classrooms in the US. The book ... Killoran , whose previous book with 23andMe, You ...
Breaking Biology News(10 mins):
(Date:1/13/2017)... , Jan 13, 2017 Research and Markets has ... to their offering. ... global biopolymers market to grow at a CAGR of 16.83% during the ... the growth prospects of the global biopolymers market for 2017-2021. To calculate ... of sales of biopolymer products. The report also includes a a discussion ...
(Date:1/12/2017)... ... January 12, 2017 , ... ... VTI, Vertebral Technologies, Inc., announces the successful outcome of the first lumbar ... 2016, VTI (Vertebral Technologies, Inc.) has partnered with Mexico-based medical product company ...
(Date:1/12/2017)... ... January 12, 2017 , ... ... treatments, 26-year-old Lisa Rosendahl’s doctors gave her only a few months to live. ... drug combination that has stabilized Rosendahl’s disease and increased both the quantity and ...
(Date:1/12/2017)... PUNE, India , January 12, 2017 The report "Direct-Fed ... Aquatic Animals), Form (Dry and Liquid), and Region - Global Forecast to 2022", ... 934.5 Million in 2016 and projected to reach USD 1,399.6 Million by 2022, ... Reading ... MarketsandMarkets Logo ...
Breaking Biology Technology: