Navigation Links
UCI-led study uncovers how Salmonella avoids the body's immune response

Irvine, Calif., March 14, 2012 UC Irvine researchers have discovered how Salmonella, a bacterium found in contaminated raw foods that causes major gastrointestinal distress in humans, thrives in the digestive tract despite the immune system's best efforts to destroy it.

Their findings help explain why Salmonella is difficult to eradicate and point to new approaches for possible treatments. Most people infected with Salmonella suffer from diarrhea, fever and abdominal cramps for up to seven days before the infection resolves.

Lead researcher Manuela Raffatellu, a UCI assistant professor of microbiology & molecular genetics, and colleagues identified a novel molecular mechanism that allows Salmonella to survive. Results of their study appear in the March issue of Cell Host & Microbe.

Pathogens like Salmonella flourish and cause disease in humans through a process by which they acquire metal ions, such as zinc, from the body. One of the body's key immune responses is to flood the infected area with antimicrobial proteins that include calprotectin, which removes zinc. Without enough of this vital element, most pathogens eventually die.

Raffatellu's team found, however, that salmonellae overcome this immune response by expressing specialized transporter proteins that enable the bacteria to acquire zinc in spite of calprotectin reducing the amount available in the digestive tract. This distinctive mechanism lets salmonellae continue proliferating.

At the same time, calprotectin inadvertently promotes Salmonella growth by killing the microbes that normally reside within the intestines and help the immune system battle pathogenic bacteria.

"We're beginning to learn more about the mechanisms that allow pathogens like Salmonella to evade our natural defenses and make us sick," Raffatellu said. "In light of this, if we can devise therapies that block the acquisition of zinc and other metals by Salmonella specifically, we can fight this infection."

Additionally, she said, the new findings may have relevance for other illnesses, such as inflammatory bowel disease and colon cancer, in which high levels of calprotectin are detected.


Contact: Tom Vasich
University of California - Irvine

Related biology news :

1. Gases drawn into smog particles stay there, UCI-led study reveals
2. UCI-led team finds new way to boost potency of marijuana-like chemical in body
3. UCI-led butterfly study sheds light on convergent evolution
4. Study demonstrates cells can acquire new functions through transcriptional regulatory network
5. University of Houston study shows BP oil spill hurt marshes, but recovery possible
6. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
7. Crystal structure of archael chromatin clarified in new study
8. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
9. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
10. BYU study: Using a gun in bear encounters doesnt make you safer
11. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
Post Your Comments:
(Date:11/9/2015)... 2015 ... "Global Law Enforcement Biometrics Market 2015-2019" ... ) has announced the addition ... Market 2015-2019" report to their offering. ... ) has announced the addition of ...
(Date:11/2/2015)... Calif. , Nov. 2, 2015  SRI International ... million to provide preclinical development services to the National ... contract, SRI will provide scientific expertise, modern testing and ... variety of preclinical pharmacology and toxicology studies to evaluate ... --> The PREVENT Cancer Drug Development Program ...
(Date:10/29/2015)... 2015 Daon, a global leader in mobile ... a new version of its IdentityX Platform , ... America have already installed IdentityX v4.0 and ... FIDO UAF certified server component as an ... FIDO features. These customers include some of the largest ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... , November 25, 2015 ... Report is a professional and in-depth study on ...      (Logo: ) , ... the industry including definitions, classifications, applications and industry ... for the international markets including development trends, competitive ...
(Date:11/24/2015)... , Nov. 24, 2015 Halozyme Therapeutics, Inc. (NASDAQ: ... in New York on Wednesday, December 2 ... Torley , president and CEO, will provide a corporate overview. ... York at 1:00 p.m. ET/10:00 a.m. PT . ... relations, will provide a corporate overview. --> th ...
(Date:11/24/2015)... -- Clintrax Global, Inc., a worldwide provider of clinical research services headquartered ... the company has set a new quarterly earnings record in Q3 ... posted for Q3 of 2014 to Q3 of 2015.   ... , with the establishment of an Asia-Pacific ... United Kingdom and Mexico , with ...
(Date:11/24/2015)... 2015 --> ... released by Transparency Market Research, the global non-invasive prenatal ... of 17.5% during the period between 2014 and 2022. ... Industry Analysis, Size, Volume, Share, Growth, Trends and Forecast ... market to reach a valuation of US$2.38 bn by ...
Breaking Biology Technology: