Navigation Links
UCI-led study uncovers how Salmonella avoids the body's immune response
Date:3/14/2012

Irvine, Calif., March 14, 2012 UC Irvine researchers have discovered how Salmonella, a bacterium found in contaminated raw foods that causes major gastrointestinal distress in humans, thrives in the digestive tract despite the immune system's best efforts to destroy it.

Their findings help explain why Salmonella is difficult to eradicate and point to new approaches for possible treatments. Most people infected with Salmonella suffer from diarrhea, fever and abdominal cramps for up to seven days before the infection resolves.

Lead researcher Manuela Raffatellu, a UCI assistant professor of microbiology & molecular genetics, and colleagues identified a novel molecular mechanism that allows Salmonella to survive. Results of their study appear in the March issue of Cell Host & Microbe.

Pathogens like Salmonella flourish and cause disease in humans through a process by which they acquire metal ions, such as zinc, from the body. One of the body's key immune responses is to flood the infected area with antimicrobial proteins that include calprotectin, which removes zinc. Without enough of this vital element, most pathogens eventually die.

Raffatellu's team found, however, that salmonellae overcome this immune response by expressing specialized transporter proteins that enable the bacteria to acquire zinc in spite of calprotectin reducing the amount available in the digestive tract. This distinctive mechanism lets salmonellae continue proliferating.

At the same time, calprotectin inadvertently promotes Salmonella growth by killing the microbes that normally reside within the intestines and help the immune system battle pathogenic bacteria.

"We're beginning to learn more about the mechanisms that allow pathogens like Salmonella to evade our natural defenses and make us sick," Raffatellu said. "In light of this, if we can devise therapies that block the acquis
'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Gases drawn into smog particles stay there, UCI-led study reveals
2. UCI-led team finds new way to boost potency of marijuana-like chemical in body
3. UCI-led butterfly study sheds light on convergent evolution
4. Study demonstrates cells can acquire new functions through transcriptional regulatory network
5. University of Houston study shows BP oil spill hurt marshes, but recovery possible
6. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
7. Crystal structure of archael chromatin clarified in new study
8. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
9. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
10. BYU study: Using a gun in bear encounters doesnt make you safer
11. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2015)... , May 6, 2015 LifeBEAM, a ... established helmet producer, announced today that they will expand ... the world,s first bio-sensing cycling helmet and the first ... in two new colors in order to give cyclists ... product. In addition, LifeBEAM and Lazer announced their plan ...
(Date:4/27/2015)... Fla. , Apr. 27, 2015 Profile ... access control and security systems is pleased to announce ... company as a consultant and member of its scientific ... is widely known as a thought leader in technology-enhanced ... Learning Technology Group, and has published studies and books ...
(Date:4/17/2015)... 17, 2015 Increasing ... technological advancement to drive biometric systems market in ...   According to a recently released ... &  Opportunities, 2020 ", biometric systems market in ... growth at CAGR of over 22% through 2020. ...
Breaking Biology News(10 mins):LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3
... between genetic factors and certain adverse events related to ... 15th issue of The Journal of Infectious Diseases, now ... from other live vaccines. , Immunization against infectious agents ... medicine, and the eradication of smallpox from the world ...
... be one step closer to finding new drugs to ... leading bioservices organisation announced that its fungal collection will ... houses one of the world’s largest genetic resource collections ... original penicillin producing isolate. They will be supplying ...
... diseases are associated with defective proteins accumulating in ... mechanisms are not operating correctly. Now, researchers at ... discovered a molecular link between the cell’s two ... succeeded in using this link to rescue neurodegenerative ...
Cached Biology News:Genetic factors are linked to fever following smallpox vaccination 2Could fungal collection hold the key to new life-saving drugs? 2Penn researchers link cell's protein recycling systems 2Penn researchers link cell's protein recycling systems 3
(Date:5/29/2015)... Worth, Texas (PRWEB) May 29, 2015 Translation ... grow. This is for a good reason--if used in a ... wonders for the offering of a business product or service ... which translation can have a positive effect on a company's ... or service that anyone in the world can use, why ...
(Date:5/28/2015)... 2015 Research ... the addition of Jain PharmaBiotech,s new ... and Companies"  to their offering.  ,     ... and evaluates animal biotechnology and its ... as well as improvement in food ...
(Date:5/28/2015)... DUBLIN , May 27, 2015 ... addition of Jain PharmaBiotech,s new report "Neuroprotection ... offering. This report describes the role ... and injuries of the nervous system as well ... because many of the underlying mechanisms of damage ...
(Date:5/28/2015)... DryLet, LLC a biotechnology company providing ... animal waste reduction, bioremediation, wastewater treatment, aquaculture and ... plants and restaurant kitchen settings, announced today it ... 3-5 in Des Moines, Iowa. , ManureMagic™ was ... Journal article because of its industry-leading qualities and ...
Breaking Biology Technology:Three Ways Translation Can Help Businesses Grow 2Global Animal Biotechnology Report 2015 - Technologies, Markets and Companies Analysis to 2024 2Global Animal Biotechnology Report 2015 - Technologies, Markets and Companies Analysis to 2024 3Global Neuroprotection Market Report 2015-2024 - Drugs, Markets and Companies 2Global Neuroprotection Market Report 2015-2024 - Drugs, Markets and Companies 3DryLet to Showcase Patented ManureMagic™ at the 2015 World Pork Expo, June 3-5 in Des Moines, Iowa 2
... Key, Fla. Climate models have long predicted that ... events. A new study conducted at the University of ... first observational evidence to confirm the link between a ... of the most serious challenges humanity will face in ...
... 7 Verenium Corporation,(Nasdaq: VRNM ), a ... in the development of high-performance specialty enzymes, announced,today ... will present at,the upcoming Canaccord Adams 28th Annual ... at 10:30 a.m. ET on Thursday, August 14,and ...
... Calif., Aug. 7 InterMune, Inc.,(Nasdaq: ITMN ) ... of InterMune, will present at the Canaccord Adams 28th ... at 1:00 p.m. EDT., To access a live ... may log on to the investor relations page of ...
Cached Biology Technology:Climate change: When it rains it (really) pours 2Verenium Corporation to Present at Canaccord Adams 28th Annual Global Growth Conference 2Verenium Corporation to Present at Canaccord Adams 28th Annual Global Growth Conference 3
Values of steady state parameters for enzyme activities are determined....
... This protein identification Service includes 1. ... protein spots 3. High-sensitive tryptic in-gel ... of samples for MALDI-MS 5. Acquisition ... via MALDI-MS (Bruker ultraflex TOF/TOF) 6. ...
... The ImageXpress 5000A automated cellular imaging ... and software system designed specifically for rapid ... high throughput cell-based screening. ImageXpress is ... full resolution (1280 x 1024 pixels), with ...
...
Biology Products: