Navigation Links
UCI-led study reveals how SARS virus hijacks host cells
Date:8/22/2013

Irvine, Calif., Aug. 22, 2013 UC Irvine infectious disease researchers have uncovered components of the SARS coronavirus which triggered a major outbreak of severe acute respiratory syndrome in 2002-03 that allow it to take over host cells in order to replicate.

This insight is critical for a full understanding of any outbreaks caused by such viruses and may prove beneficial in the development of therapies not only for human coronavirus infections but for other pathogenic illnesses as well. Study results appear online in the July/August issue of mBio.

Megan Angelini, a graduate student in Professor Michael Buchmeier's laboratory in the Department of Molecular Biology & Biochemistry at UC Irvine, and colleagues found that three proteins in the SARS coronavirus nsp3, nsp4 and nsp6 have the ability to hijack a host cell's internal membranes and utilize them to make more virus.

"Understanding how the virus uses the host cell to reproduce itself could lead to potential therapies for these kinds of pathogens," said Buchmeier, who is also deputy director of the Pacific Southwest Regional Center of Excellence for Biodefense & Emerging Infectious Diseases at UC Irvine.

Additionally, he said, since membrane rearrangement is a tactic employed by all known positive-sense, single-stranded RNA viruses, including those responsible for polio and dengue fever, this work adds to that body of knowledge.

Although the majority of infections caused by coronaviruses in humans are relatively mild, the SARS outbreak of 2002 and 2003 and the emergence last fall of the Middle East respiratory syndrome coronavirus highlight their ability to potentially infect millions around the globe.


'/>"/>

Contact: Andrea Burgess
andrea.burgess@uci.edu
949-824-6282
University of California - Irvine
Source:Eurekalert

Page: 1

Related biology news :

1. Circadian rhythms control bodys response to intestinal infections, UCI-led study finds
2. UCI-led study uncovers how Salmonella avoids the bodys immune response
3. Human brains are hardwired for empathy, friendship, study shows
4. 23andMe conducts the first genetic study of non-syndromic striae distensae (stretch marks)
5. Major study links aging gene to blood cancer
6. BIDMC cardiovascular institute researchers will lead $4 million NIH grant to study micrornas
7. ITN type 1 diabetes study identifies subset of patients with strong response to therapy
8. Rutgers study: Worms may shed light on human ability to handle chronic stress
9. Researchers study seleniums effects on horses
10. Latino families in study eat more fruits and veggies, drink less soda
11. Study finds novel worm community affecting methane release in ocean
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... The Mills Canyon fire started near the City of ... of local resources, the fire quickly grew to over ... cause of the fire is under investigation by the ... is working with existing local resources in developing fire ... Forest Service (USFS), Washington State Department of Natural Resources, ...
(Date:7/11/2014)... the National Institute of Standards and Technology (NIST) ... more effectively, they often prove that necessity is ... case recently for M. Lorna De Leoz and ... specialization of glycomics. Glycomics is the study of ... are attached to proteins and lipids and influence ...
(Date:7/11/2014)... Sweden, have explored two different ways that allow ... to the formation of oxygen molecules in photosynthesis. ... scientific journal Nature Communications . , "The ... catalysts for water oxidation, which are key components ... storage of solar energy in fuels like hydrogen, ...
Breaking Biology News(10 mins):Molecular snapshots of oxygen formation in photosynthesis 2
... This news release is available in German . ... like father, like son. Evolutionary biologists at the universities in Bielefeld ... applies to inheriting a long life at least for fruit ... of these insects mostly inherit their lifespan from their own sex: ...
... WASHINGTON , Sept. 13, 2013  LaserLock Technologies ... and persons, announced today that it has filed ... of Independent Authentication Mechanisms". The system authenticates human ... simple user experience and a higher degree of ...
... emissions, which are projected to set the global mean ... expose 668 million people worldwide to new or aggravated ... study published today, 13 September, in IOP Publishing,s journal ... a further 11 per cent of the world,s population, ...
Cached Biology News:Inheritance of lifespan is sex-dependent in fruit flies 2LaserLock Technologies Files A New Provisional Patent Which Secures Player Identity On Internet Gaming Platforms 2LaserLock Technologies Files A New Provisional Patent Which Secures Player Identity On Internet Gaming Platforms 3Current pledges put over 600 million people at risk of higher water scarcity 2
(Date:7/10/2014)... of Adelaide research may help in the fight against ... detect tiny quantities of explosives with the use of ... journal Sensors and Actuators B: Chemical , the ... detect explosives in concentrations as low as 6.3 ppm ... only a few minutes. , "Traditionally explosives detection has ...
(Date:7/10/2014)... been extremely challenging because there are many genetic variants ... disease. Now investigators reporting in the July 3rd issue ... describe a strategy that may help reveal how ... or environmental exposures to affect the development of the ... may predispose individuals to schizophrenia. , The work ...
(Date:7/10/2014)... upside down forever. Nanophysics makes sure of that. Mechanics researchers ... published in Physical Review E . Knowledge that can ... seem to be able to sit still forever, and walk ... We will soon be able to buy smart new fasteners ... the fact is, sooner or later the grip is lost, ...
(Date:7/10/2014)... new alliance will see the two universities and NPL ... with business and industry and their complementary academic strengths., ... help to shape the scientific priorities of the UK. ... up to 300 high-calibre PhD students, will provide a ... NPL, the potential of the Laboratory will be grown ...
Breaking Biology Technology:Detecting trace amounts of explosives with light 2New strategy could uncover genes at the root of psychiatric illnesses 2Even geckos can lose their grip 2Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 2Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 3
... Feb. 6 Thermo Fisher,Scientific Inc. (NYSE: TMO ... increased to a record $2.62 billion in the fourth ... 2006 merger with Fisher,Scientific), compared with $1.67 billion in ... $.54 in 2007, versus $0.08 in the year-ago,period. GAAP ...
... for detecting explosives and poisons could,be developed following new ... today (3 February) in Nature Photonics. , The ... far,infrared part of the electromagnetic spectrum that have a ... along the surface of a,specially designed material, known as ...
... Quest Executive Director Brings Extensive Strategic Marketing ... ... Transgenomic, Inc. (OTC,Bulletin Board: TBIO), today announced that it has appointed ... a consultant,at Water Street Healthcare Partners, a Chicago-based private equity firm,specializing ...
Cached Biology Technology:Thermo Fisher Scientific Reports Record 2007 Fourth Quarter Revenues and Operating Performance; Provides Guidance for 2008 2Thermo Fisher Scientific Reports Record 2007 Fourth Quarter Revenues and Operating Performance; Provides Guidance for 2008 3Thermo Fisher Scientific Reports Record 2007 Fourth Quarter Revenues and Operating Performance; Provides Guidance for 2008 4Thermo Fisher Scientific Reports Record 2007 Fourth Quarter Revenues and Operating Performance; Provides Guidance for 2008 5Thermo Fisher Scientific Reports Record 2007 Fourth Quarter Revenues and Operating Performance; Provides Guidance for 2008 6Thermo Fisher Scientific Reports Record 2007 Fourth Quarter Revenues and Operating Performance; Provides Guidance for 2008 7Thermo Fisher Scientific Reports Record 2007 Fourth Quarter Revenues and Operating Performance; Provides Guidance for 2008 8Thermo Fisher Scientific Reports Record 2007 Fourth Quarter Revenues and Operating Performance; Provides Guidance for 2008 9Thermo Fisher Scientific Reports Record 2007 Fourth Quarter Revenues and Operating Performance; Provides Guidance for 2008 10Thermo Fisher Scientific Reports Record 2007 Fourth Quarter Revenues and Operating Performance; Provides Guidance for 2008 11Thermo Fisher Scientific Reports Record 2007 Fourth Quarter Revenues and Operating Performance; Provides Guidance for 2008 12Thermo Fisher Scientific Reports Record 2007 Fourth Quarter Revenues and Operating Performance; Provides Guidance for 2008 13Thermo Fisher Scientific Reports Record 2007 Fourth Quarter Revenues and Operating Performance; Provides Guidance for 2008 14Thermo Fisher Scientific Reports Record 2007 Fourth Quarter Revenues and Operating Performance; Provides Guidance for 2008 15Thermo Fisher Scientific Reports Record 2007 Fourth Quarter Revenues and Operating Performance; Provides Guidance for 2008 16Thermo Fisher Scientific Reports Record 2007 Fourth Quarter Revenues and Operating Performance; Provides Guidance for 2008 17Thermo Fisher Scientific Reports Record 2007 Fourth Quarter Revenues and Operating Performance; Provides Guidance for 2008 18Thermo Fisher Scientific Reports Record 2007 Fourth Quarter Revenues and Operating Performance; Provides Guidance for 2008 19Thermo Fisher Scientific Reports Record 2007 Fourth Quarter Revenues and Operating Performance; Provides Guidance for 2008 20Thermo Fisher Scientific Reports Record 2007 Fourth Quarter Revenues and Operating Performance; Provides Guidance for 2008 21Thermo Fisher Scientific Reports Record 2007 Fourth Quarter Revenues and Operating Performance; Provides Guidance for 2008 22'T-ray' breakthrough signals next generation of security sensors 2Transgenomic Appoints David Pauluzzi to Board of Directors 2Transgenomic Appoints David Pauluzzi to Board of Directors 3
... Immunogen corresponds to amino acids 2-105 from ... been successfully used in Western blot, immunocytochemistry ... this antibody detects an ~ 60 kDa ... also been used in immunoprecipitation and immunocytochemical ...
Caspr2 Antigen: Fusion protein amino acids 96-1265 (extracellular domain) of human Caspr2 Accession Number: NP_054860...
... a new tuning and calibration standard for ... Accumix is a lyophilized 7-peptide standard ... both tuning and calibration of ion trap ... transform mass spectrometers. Direct infusion of ...
... White crystalline solid. HYGROSCOPIC. Water-soluble zwitterionic detergent ... 252005) but differing in the length of ... extraction of mycoplasma membrane antigens under mild ... TLC. Soluble in H 2 O. ...
Biology Products: