Navigation Links
UCI-led study reveals how SARS virus hijacks host cells
Date:8/22/2013

Irvine, Calif., Aug. 22, 2013 UC Irvine infectious disease researchers have uncovered components of the SARS coronavirus which triggered a major outbreak of severe acute respiratory syndrome in 2002-03 that allow it to take over host cells in order to replicate.

This insight is critical for a full understanding of any outbreaks caused by such viruses and may prove beneficial in the development of therapies not only for human coronavirus infections but for other pathogenic illnesses as well. Study results appear online in the July/August issue of mBio.

Megan Angelini, a graduate student in Professor Michael Buchmeier's laboratory in the Department of Molecular Biology & Biochemistry at UC Irvine, and colleagues found that three proteins in the SARS coronavirus nsp3, nsp4 and nsp6 have the ability to hijack a host cell's internal membranes and utilize them to make more virus.

"Understanding how the virus uses the host cell to reproduce itself could lead to potential therapies for these kinds of pathogens," said Buchmeier, who is also deputy director of the Pacific Southwest Regional Center of Excellence for Biodefense & Emerging Infectious Diseases at UC Irvine.

Additionally, he said, since membrane rearrangement is a tactic employed by all known positive-sense, single-stranded RNA viruses, including those responsible for polio and dengue fever, this work adds to that body of knowledge.

Although the majority of infections caused by coronaviruses in humans are relatively mild, the SARS outbreak of 2002 and 2003 and the emergence last fall of the Middle East respiratory syndrome coronavirus highlight their ability to potentially infect millions around the globe.


'/>"/>

Contact: Andrea Burgess
andrea.burgess@uci.edu
949-824-6282
University of California - Irvine
Source:Eurekalert

Page: 1

Related biology news :

1. Circadian rhythms control bodys response to intestinal infections, UCI-led study finds
2. UCI-led study uncovers how Salmonella avoids the bodys immune response
3. Human brains are hardwired for empathy, friendship, study shows
4. 23andMe conducts the first genetic study of non-syndromic striae distensae (stretch marks)
5. Major study links aging gene to blood cancer
6. BIDMC cardiovascular institute researchers will lead $4 million NIH grant to study micrornas
7. ITN type 1 diabetes study identifies subset of patients with strong response to therapy
8. Rutgers study: Worms may shed light on human ability to handle chronic stress
9. Researchers study seleniums effects on horses
10. Latino families in study eat more fruits and veggies, drink less soda
11. Study finds novel worm community affecting methane release in ocean
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... -- On April 6-7, 2017, Sequencing.com will host the world,s ... at Microsoft,s headquarters in Redmond, Washington ... health and wellness apps that provide a unique, personalized ... is the first hackathon for personal genomics and the ... the genomics, tech and health industries are sending teams ...
(Date:3/29/2017)...  higi, the health IT company that operates the ... , today announced a Series B investment from ... The new investment and acquisition accelerates higi,s strategy to ... population health activities through the collection and workflow integration ... collects and secures data today on behalf of over ...
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. ... have received the prestigious international IAIR Award for the most innovative ... ... Maldives Immigration ... Algeen (small picture on the right) have received the IAIR award for ...
Breaking Biology News(10 mins):
(Date:7/20/2017)... ... July 20, 2017 , ... Resoundant, Inc. is pleased ... centers around the U.S. that offer MR Elastography for liver fibrosis staging. ... biopsy for staging liver fibrosis assessment. , “MRE:connect was created in response to ...
(Date:7/20/2017)... ... July 20, 2017 , ... ... digital pathology and artificial intelligence Tuesday, July 25, during the Association of Pathology ... Johns Hopkins Medicine. , Baras, Associate Director of Pathology Informatics, will present ...
(Date:7/18/2017)... , ... July 18, 2017 , ... ... accelerate pharmaceutical and biotherapeutics development, announces the launch of a new NTA biosensor ... chip enables researchers to study the kinetics of polyhistidine-tagged (His-tagged) molecules quickly and ...
(Date:7/18/2017)... ... ... Blood centers traditionally see a dangerous drop of blood donations during the ... community blood centers as high schools are out and many frequent donors are on ... up with the South Texas Blood & Tissue Center (STBTC), a subsidiary ...
Breaking Biology Technology: