Navigation Links
UCI chemists devise inexpensive, accurate way to detect prostate cancer
Date:5/22/2013

Irvine, Calif., May 22, 2013 Early screening for prostate cancer could become as easy for men as personal pregnancy testing is for women, thanks to UC Irvine research published today in the Journal of the American Chemical Society.

After more than a decade of work, UC Irvine chemists have created a way to clearly identify clinically usable markers for prostate cancer in urine, meaning that the disease could be detected far sooner, with greater accuracy and at dramatically lower cost. The same technology could potentially be used for bladder and multiple myeloma cancers, which also shed identifiable markers in urine.

"Our goal is a device the size of a home pregnancy test priced around $10. You would buy it at the drugstore or the grocery store and test yourself," said the study's corresponding author, Reginald Penner, UC Irvine Chancellor's Professor of chemistry. "We're on the verge of a very important breakthrough in a new era of personal health management."

About 240,000 men in the U.S. are diagnosed with prostate cancer each year, and 29,000 are expected to die of it in 2013. But current, widely utilized testing does not always catch the disease in its early stages, often yields false positives and can lead to unnecessary, risky treatments. A recent report concluded that the prostate-specific antigen, or PSA, test can be more harmful than beneficial, although it remains important for detecting recurring prostate cancer. The UC Irvine researchers used a different biomarker, PSMA, and plan to test others to pinpoint if a cancer is growing aggressively or not.

"A big problem is that the approach used now does not catch cancer soon enough," said co-author Gregory Weiss, a UC Irvine biochemist. "We want this to be a disruptive technology that will change how we save lives and that will bring down healthcare costs drastically."

The researchers used a combination of readily available chemicals and unique electronic sensors to create the screening process.

Salt in urine helps conduct electricity but also makes it challenging for typical biosensors to differentiate the "signals" of cancer molecules from "noise" around them in the electrodes. The UC Irvine team developed a new type of sensor: They added nanoscale protein receptors to tiny, pencil-like viruses called phages that live only within bacteria. Double wrapping the phages with additional receptors greatly increases the capture and transmission of cancer molecule signals.

"We add a high concentration of the viruses, and they get trapped directly in the electrode. We're jamming the signal with the cancer marker, and it stays on louder than all the other material," said lead author Kritika Mohan, a graduate student with Weiss' lab. "To our surprise, it works really well in the ingredients that make up urine."

The next step is human clinical trials, which the researchers hope can be conducted fairly quickly since the testing will be noninvasive. The method has been patented and licensed, and a commercial partner has been identified.

Ultimately, the scientists aim to capitalize on related nanowire research to design invisible filaments that could carry cancer signals to a smartphone or other electrical device. Software would notify users whether they're in the safe range or should contact a physician.

Other prostate cancer tests coming to market cost up to $4,000 each. The UC Irvine team made price a key design factor of their work.

"The manufacturing costs would be low, because the material costs are very, very low. The receptors for recognizing the cancer markers are really inexpensive to make. That's why we chose these viruses," Weiss said. "They're grown in a yeasty, brothy solution kind of like chicken broth that could easily be mixed on a huge scale."

He added that the receptors are also "incredibly tough." They don't need to be refrigerated and can withstand nearly boiling temperatures, meaning the portable tests could be used in myriad weather conditions and storage situations.


'/>"/>

Contact: Janet Wilson
janet.wilson@uci.edu
949-824-3969
University of California - Irvine
Source:Eurekalert

Related biology news :

1. Chemists devise inexpensive, benchtop method for marking and selecting cells
2. Chemists develop reversible method of tagging proteins
3. Chemists advance clear conductive thin films
4. UMass Amherst biochemists developing tools to stop plague and other bacterial threats
5. UC Berkeley chemists installing first carbon dioxide sensor network in Oakland
6. Inexpensive, abundant starch fibers could lead to ouchless bandages
7. Blowing in the wind: How accurate is thermography of horses legs?
8. APL novel method accurately predicts disease outbreaks
9. More accurate, sensitive DNA test allows early identification of fungus causing WNS
10. Plants provide accurate low-cost alternative for diagnosis of West Nile Virus
11. More accurate wind energy forecasts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2016)... PROVIDENCE, R.I. , March 31, 2016  Genomics ... leadership of founding CEO, Barrett Bready , M.D., ... addition, members of the original technical leadership team, including ... Vice President of Product Development, Steve Nurnberg and Vice ... have returned to the company. Dr. Bready ...
(Date:3/22/2016)... PROVO and SANDY, ... Screening Ontario (NSO), which operates the highest sample volume ... testing, and Tute Genomics and UNIConnect, leaders in clinical ... today announced the launch of a project to establish ... testing panel. NSO has been contracted ...
(Date:3/15/2016)... , March 15, 2016 --> ... published by Transparency Market Research "Digital Door Lock Systems Market ... 2015 - 2023," the global digital door lock systems market ... in 2014 and is forecast to grow at a CAGR ... micro, small and medium enterprises (MSMEs) across the world and ...
Breaking Biology News(10 mins):
(Date:5/20/2016)... ... May 20, 2016 , ... The leading Regenerative Veterinary Medicine Company, ... veterinary clients have treated over 100 of their own patients with the VetStem Cell ... highest level of care for their patients. , The veterinarians are Dr Ross ...
(Date:5/19/2016)... Ashland, Virginia (PRWEB) , ... May 19, 2016 , ... ... a new 30,000 square foot office building is complete. The new structure adds a ... In 2011, Anton Paar USA purchased 2.4 acres of land, along with ...
(Date:5/19/2016)... 19, 2016 Regen ... PINK: RGBPP) announced today initiation of a preclinical ... blood based cancer immunotherapeutic product leveraging its NR2F6 ... described a generation of cord blood derived killer ... silencing.  The product in development will be a ...
(Date:5/18/2016)... , May 18, 2016 The Biotech ... does not mean that there are no opportunities ahead. Today, ... Inc. (NASDAQ: THLD ), Seattle Genetics Inc. (NASDAQ: ... ), and Ophthotech Corp. (NASDAQ: OPHT ). Sign ... at: http://www.activewallst.com/ Threshold Pharmaceuticals ...
Breaking Biology Technology: