Navigation Links
UCI, French researchers find master switch for adult epilepsy
Date:6/27/2011

ut three dozen other important genes are altered by a major cellular repressor called NRSF, which increases after events that give rise to epilepsy.

NRSF proteins work by attaching to the DNA of selected genes and shutting them down, causing neurons to fire abnormally and promoting the development of epilepsy. This was discovered when Baram and her colleagues prevented NRSF from linking to HCN1 and other NRSF-regulated genes, the development of epilepsy was markedly lessened.

This NRSF binding process is an example of epigenetics enduring changes to gene expression without changes to the DNA sequence. Baram said the study is the first to show the significance of epigenetic mechanisms in the formation of epilepsy. The findings also point to NRSF having a larger role in influencing brain activity.

"NRSF operates like a master switch on many genes affecting neuron function," said Shawn McClelland, UCI researcher and study co-author. "And if its levels increase, it can provoke changes lasting for years."

"We're quite excited about this discovery," Baram said. "Understanding how previous brain infections, seizures or injuries can interact with the cellular machinery to cause epilepsy is a crucial step toward designing drugs to prevent the process. We don't want to just treat people with epilepsy. We hope to develop medicines that will prevent epilepsy from occurring and influence the lives of millions of people around the globe."

The founder of UCI's Epilepsy Research Center, Baram is considered the world's leading investigator of the basic neural mechanisms involved in childhood febrile seizures those caused by high fever and how prolonged febrile seizures might lead to the onset of TLE.


'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related biology news :

1. French scientist wins the Journal of Experimental Biology Outstanding Paper Prize
2. French Authorities Give Sole Approval to GMAT Exam to Collect Biometric Data to Advance Security
3. French scientist wins the Journal of Experimental Biology Outstanding Paper Prize 2009
4. French and Spanish researchers develop a natural alternative to antibiotics in animal feed
5. Road salt and cars produce extreme water contamination in Frenchmans Bay, UTSC research reveals
6. French national research agency funds PREDIMOL project
7. Springer and the French National Institute for Agricultural Research INRA team up
8. First French bulldog with sex reversal identified in Spain
9. NC State researchers get to root of parasite genome
10. Researchers find animal with ability to survive climate change
11. Researchers find an essential gene for forming ears of corn
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... 10, 2014  That blood pressure plays a role in ... – the medical term for high blood pressure – was ... the inflatable cuff that,s used in measuring blood pressure was ... nothing new about hypertension, its triggers and its effects. In ... condition and the best ways to treat it. ...
(Date:12/10/2014)... You,ve been here before: you desperately need to ... password, site key or the answer to your secret question. ... Today, Hoyos Labs , a digital ... finally put an end to the frustration that comes with ... 1U leverages a user,s smartphone to acquire his or her ...
(Date:12/10/2014)...  Wake Forest Baptist Medical Center today announced plans for ... Medicine. Funding for this $50 million capital project is ... publicly launched next summer. The medical ... series R.J. Reynolds Tobacco Company complex, adjacent to 525@vine ... with plans to be ready to welcome medical students ...
Breaking Biology News(10 mins):Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4
... New knowledge points to the fact that a genetically ... skin barrier, plays a decisive role in the origin ... 3000 school-children scientists of the Helmholtz Zentrum Mnchen and ... the German population carry variations of the filaggrin gene, ...
... (MS), neuroradiologists and neurologists of the University hospitals of ... tissue damage, most of which had remained unrecognized up ... medium, Gadofluorine M, in magnetic resonance imaging. The scientists ... the renowned medical journal Brain . ...
... , Now that Olympia is approaching, the Chinese authorities ... large cities with different measures. For example, the car ... ordered not to use 70 percent of all company ... even or odd days - in accordance with their ...
Cached Biology News:When our protective armor shows weakness 2Multiple Sclerosis: new MRI contrast medium enables early diagnosis in animal model 2GKSS membranes reduce air pollution in Beijing 2
(Date:12/24/2014)... (PRWEB) December 23, 2014 GMO corn ... biotechnology company, Syngenta, are in the process of being ... The consolidated case is In Re: Syngenta AG MIR ... District Court for the District of Kansas. , Management ... been handed over to U.S. District Judge John W. ...
(Date:12/24/2014)... The report provides basic ... definition, classification, application and industry overview. This ... and product cost structure. Production is separated ... also covers upstream raw materials, equipment, downstream ... and proposals. In the end, the export ...
(Date:12/24/2014)... AUSTIN, Texas , Dec. 23, 2014 /PRNewswire/ ... solutions company focused on gynecologic disease, announced today ... W. Schuler , Birchview Fund LLC and several ... million of unregistered shares of Vermillion,s common stock ... common stock in a private placement.  ...
(Date:12/22/2014)... PA & Brussels (PRWEB) December 22, 2014 ... (CfPIE), the global leader of technical training across ... Society for Clinical Data Management (SCDM) to provide ... and certification programs —providing access to the more ... partnership extends SCDM members with 10% off when registering ...
Breaking Biology Technology:Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3
... spotlight on the,ever-growing field of life sciences, Larta Institute,s ... in the midst of the dark backdrop of the,current ... to,focus on brilliant entrepreneurs in the life sciences, even ... years, through good,economic times and bad, the passion and ...
... 14 Access Pharmaceuticals, Inc.,(OTC Bulletin Board: ACCP) announced ... & Renshaw 5th Annual Global Healthcare Conference to be ... in Monte Carlo, Monaco.,Jeffrey B. Davis, CEO of Access ... 3:10 pm local time, 9:10 am Eastern time and ...
... May 14 /PRNewswire-FirstCall/ - Oncolytics Biotech Inc.,("Oncolytics") ... has,received a letter of approval from the ... for its Clinical Trial Application (CTA),to begin ... administration of,REOLYSIN(R) in combination with paclitaxel and ...
Cached Biology Technology:Betting on Change - The Venture Forum in 2008 2Betting on Change - The Venture Forum in 2008 3Access Pharmaceuticals to Present at the Rodman & Renshaw 5th Annual Global Healthcare Conference 2Oncolytics Biotech Inc. Announces U.K. Phase II Clinical Trial Investigating REOLYSIN(R) in Combination with Paclitaxel and Carboplatin 2
... host strains are K-12 derivatives that have ... and glutathione reductase (gor) genes, which greatly ... Studies have shown that expression in Origami(DE3) ... another host even though overall expression levels ...
Recommend to use at 1000X dilutions for cell culture (e.g. Add 1 ul to 1 ml of culture medium.)...
... Kit, 1 kit. Convenient way ... Conjugations are carried out under mild ... Dyes are packaged in premeasured amounts ... Category: Blotting & Labeling & Detection, ...
Recombinant Human Erythropoietin (Tissue Culture Grade)...
Biology Products: