Navigation Links
UCI, French researchers find master switch for adult epilepsy
Date:6/27/2011

Irvine, Calif., June 27, 2011 UC Irvine and French researchers have identified a central switch responsible for the transformation of healthy brain cells into epileptic ones, opening the way to both treat and prevent temporal lobe epilepsy.

Epilepsy affects 1 to 2 percent of the world's population, and TLE is the most common form of the disorder in adults. Among adult neurologic conditions, only migraine headaches are more prevalent. TLE is resistant to treatment in 30 percent of cases.

UCI neurologist and neuroscientist Dr. Tallie Z. Baram and her colleagues found that TLE manifests after a major reorganization of the molecules governing the behavior of neurons, the cells that communicate within the brain. These alterations often stem from prolonged febrile seizures, brain infections or trauma.

"This discovery marks a dramatic change in our understanding of how TLE comes about. Previously, it was believed that neurons died after damaging events and that the remaining neurons reorganized with abnormal connections," said Baram, the Danette Shepard Chair in Neurological Studies. "However, in both people and model animals, epilepsy can arise without the apparent death of brain cells. The neurons simply seem to behave in a very abnormal way."

To learn why, Baram's UCI team collaborated with a French group led by Christophe Bernard of the University of Marseille and Inserm. They focused on ion channels, molecules that straddle the boundaries of brain cells and govern how they fire and communicate among themselves.

Specifically, they explored an ion channel called HCN1 which is suppressed in response to brain seizures, injuries and infections that lead to epilepsy hoping to find the long-sought mechanism that triggers epileptic activity in previously normal brain cells.

In their study, which appears online in the Annals of Neurology, the researchers reveal that mechanism: The HCN1 channel gene and abo
'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related biology news :

1. French scientist wins the Journal of Experimental Biology Outstanding Paper Prize
2. French Authorities Give Sole Approval to GMAT Exam to Collect Biometric Data to Advance Security
3. French scientist wins the Journal of Experimental Biology Outstanding Paper Prize 2009
4. French and Spanish researchers develop a natural alternative to antibiotics in animal feed
5. Road salt and cars produce extreme water contamination in Frenchmans Bay, UTSC research reveals
6. French national research agency funds PREDIMOL project
7. Springer and the French National Institute for Agricultural Research INRA team up
8. First French bulldog with sex reversal identified in Spain
9. NC State researchers get to root of parasite genome
10. Researchers find animal with ability to survive climate change
11. Researchers find an essential gene for forming ears of corn
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2015)... JOSE, Calif. , July 9, 2015 ... the leading developer of human interface solutions, ... technology, the industry,s first fully hardware encapsulated ... Match-in-Sensor secure authentication technology is literally off ... storage and biometric matching within the fingerprint ...
(Date:7/8/2015)... 2015 The consumer products industry for ... have products such as wearables, smart wallets & other smart ... based devices continues to rapidly grow.  Biometrics & Wearable Device ... ), Google Inc. (NASDAQ: GOOG ), Apple Inc. (NASDAQ: ... Inc. (NASDAQ: GPRO ) and Baidu Inc. (NASDAQ: ...
(Date:7/2/2015)... DUBLIN , June 25, 2015 ... has announced the addition of the "Natural ... Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image ... to their offering. The key vendors ... Google, HP, IBM Corporation, Microsoft Corporation, NetBase Solutions, ...
Breaking Biology News(10 mins):Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 2Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 3Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 4Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 5Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 6Natural Language Processing Market by Type (Rule-Based, Statistical, and Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) - Worldwide Forecast to 2020 2
... 13th January print edition of the journal Current ... into an old mystery in cell biology, and offer ... and Mnica Bettencourt Dias, working with researchers at the ... mystery of how cells count the number of centrosomes, ...
... painstakingly handwritten books produced in medieval Europe still exist ... when and where the majority of these works originated. ... using modern advances in genetics to develop techniques that ... cultural artifacts. Many medieval manuscripts were written on ...
... book, Wonderful World, Stephen Jay Gould writes about an experiment ... time, let the tape of life play again and see ... biology tells us that it wouldn,t look the same ... before. Now, scientists at the Instituto Gulbenkian de Cincia (IGC) ...
Cached Biology News:How do cells count? 2DNA testing may unlock secrets of medieval manuscripts 2Reverse evolution in real-time 2
(Date:8/4/2015)... , Aug. 4, 2015 /PRNewswire/ -- Sinovac Biotech Ltd. ... products in China , today announced ... the second quarter, ended June 30, 2015, after market ... a conference call on Thursday, August 13, 2015, at ... p.m. China Standard Time) to review the Company,s financial ...
(Date:8/3/2015)... -- MiMedx Group, Inc. (NASDAQ: MDXG ), the leading ... processes to develop and market advanced products and therapies ... Ophthalmic and Dental sectors of healthcare, announced today that ... Canaccord|Genuity Growth Conference in Boston, Massachusetts ... William C. Taylor , President and COO, and ...
(Date:8/3/2015)... Medical, Inc. (Nasdaq: AEMD ), the pioneer in ... announced that it will host its First Quarter Fiscal ... 13, 2015 at 4:30 p.m. Eastern Time. ... fiscal 2016 first quarter results.  A recorded version of ... the call at the Investor Relations portion of the ...
(Date:8/3/2015)... , Aug. 3, 2015 /PRNewswire/ - RepliCel Life Sciences ... company focused on the development of autologous cell therapies, announced ... presenting at the InvestMNT conference held in Minneapolis, ... AM local time. Hall,s presentation will highlight RepliCel,s 18-month milestones ... in Europe , clinical data from both ...
Breaking Biology Technology:Sinovac to Host Conference Call to Report Second Quarter 2015 Unaudited Financial Results 2MiMedx To Present At 35th Annual Canaccord|Genuity Growth Conference 2Aethlon Medical To Host First Quarter Fiscal 2016 Investor Call on August 13, 2015 2RepliCel Presenting at InvestMNT Investor Conference in Minneapolis 2
... , Introduction ... staples in the diets of all countries. The ability to produce enough crops ... enough to eat before they can advance to higher endeavors. , ... the occurrence of frost, wind erosion, etc., can be detrimental to the success ...
... Introduction , ... to environmental protection. In addition to the obvious necessity of ... trace the source of a dangerous material and contribute to ... <P,>A substantial body of research has clearly established the efficiency ...
... , , Reduced-Volume Samples , 20 L, 50 ... Samples <br ,>enzymes polymers amino acids ,<P ... <P ,>Samples can be valuable. Either you dont want ... with which to start. Biological proteins and enzymes, for example, ...
Cached Biology Technology:Food science: increasing crop yields 2Screening and classifying hazardous waste samples 2Screening and classifying hazardous waste samples 3Screening and classifying hazardous waste samples 4Screening and classifying hazardous waste samples 5
... Imaging Systems group announces the availability ... Imaging Systems, featuring high resolution cooled ... luminescence, radiographic and chromogenic imaging capability. ... and 10x optical zoom lens provides ...
... It has been demonstrated that oxidative stress ... and cancer. Oxidative stress is the condition ... and physiological antioxidants exist leading to the ... response to oxidative stress is through several ...
Compound(s) tested through a broad panel of 38 ligand binding and enzyme assays targeting the Central Nervous System. Used to determine selectivity and potential Neurological liabilities of compound...
Compound(s) screened through any number of client selected assays. Client also selects number of concentrations and replicates....
Biology Products: