Navigation Links
UCF nanotechnology may speed up drug testing
Date:12/19/2011

Testing the effectiveness of new pharmaceuticals may get faster thanks to a new technique incorporating quantum dots developed at the University of Central Florida.

Some drug testing can take a decade or more, but UCF associate professor Swadeshmukul Santra and his team have created an electronic quantum dots (Qdots) probe that "lights up" when a drug it is delivering attaches to cancer cells. The research appears online in this month's Biomaterials. http://www.sciencedirect.com/science/article/pii/S0142961211012841#FCANote

A researcher can use a microscope to see where and how much of the drug has been delivered because the probe emits a reddish color under special lighting or via MRI because of its optical and magnetic components.

As the drug testing continues, images can be taken over and over without any loss of optical or MRI signal. Researchers can then measure the size of the tumor and number of cancer cells that "light up" compared with the original untreated tumor.

This provides a way to determine whether the drug is doing what it is supposed to be doing in the targeted areas. The technique is much easier than the current process of removing treated cancer tumors and weighing them at regular intervals to determine the drug's efficiency in an animal.

"Many people in my area have been studying this approach for years," Santra said. "But we have now moved it into a live cell, not just in test tubes."

Sudiptal Seal, the director of UCF's NanoScience Technology Center and nanoscience scientist believes Santra's research is significant.

"This is indeed a major breakthrough in Qdot research," Seal said. "This new diagnostic tool will certainly impact the field of nanomedicine."

Santra and his team used semiconductor Qdots to create the probe. Because of their small size and crystal-like structure, Qdots display unique optical and electronic properties when they get excited. These unique properties make them ideal for sustained and reliable imaging with special lights.

For this research funded by the National Science Foundation and National Institutes of Health, the UCF-led team used a superparamagnetic iron oxide nanoparticle core decorated with satellite CdS:Mn/ZnS Qdots which carried the cancer-fighting agent STAT3 inhibitor. The Qdot optical signal turned on when the probe bonded with the cancer cells.

"The potential applications for drug testing specifically for cancer research are immediate," Santra said.


'/>"/>

Contact: Zenaida Kotala
zenaida.kotala@ucf.edu
407-823-6120
University of Central Florida
Source:Eurekalert  

Related biology news :

1. Europe rallies behind nanotechnology to wean world from fossil fuels
2. Nanotechnology boosts war on superbugs
3. NIST, NCI bring web 2.0 tools to nanotechnology standards effort
4. Nanotechnology culture war possible, says Yale study
5. Donation for new Center for Pharmaceutical Nanotechnology and Nanotoxicology
6. Nanotechnology holds promise for STD drug delivery
7. University awarded £1.7M to develop nanotechnology for use in health care
8. Singapore nanotechnology combats fatal brain infections
9. New DNA test uses nanotechnology to find early signs of cancer
10. Nanotechnology and synthetic biology: What does the American public think?
11. Step forward for nanotechnology: Controlled movement of molecules
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCF nanotechnology may speed up drug testing
(Date:2/2/2016)... 2, 2016  BioMEMS devices deployed in ... on medical screening and diagnostic applications, such ... devices that facilitate and assure continuous monitoring ... are being bolstered through new opportunities offered ... acquisition coupled with wireless connectivity and low ...
(Date:2/2/2016)... 2016   Parabon NanoLabs (Parabon) announced ... Research Office and the Defense Forensics and Biometrics ... the company,s Snapshot Kinship Inference software ... generally, defense-related DNA forensics.  Although Snapshot is best ... and ancestry from DNA evidence), it also has ...
(Date:2/1/2016)... Feb. 1, 2016  Wocket® smart wallet ( www.wocketwallet.com ) announces the ... Joey Fatone . Las Vegas , where ... --> Las Vegas , where Joey appeared at ... The new video ad was filmed at the Consumer Electronics Show (CES2016) ... Wocket booth to meet and greet fans. --> ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... 2016 NX Prenatal Inc., a US ... technology for early warning of adverse pregnancy outcomes, ... study by Dr. Thomas McElrath of ... Fetal Medicine,s (SMFM) annual meeting held in ... 2016.  The presentation reported initial positive top-line results ...
(Date:2/10/2016)... Wash., Feb. 10, 2016  IsoRay, Inc. (NYSE MKT: ... brachytherapy and medical radioisotope applications for the treatment of ... today announced its financial results for the second quarter ... 31, 2015. --> ... quarter of fiscal 2016, which ended December 31, 2015, ...
(Date:2/10/2016)... ... February 10, 2016 , ... Benchmark Research, ... the promotion of two long-standing principal investigators (PI) to the roles of Chief ... and Development. , Dr. Laurence Chu, a Benchmark Research PI in the Austin ...
(Date:2/10/2016)... , ... February 10, 2016 , ... ... to their comprehensive training and support program, Sonalinkā„¢ remote monitoring. The inaugural launch ... performed on Friday, February 5th, connecting Dr. Samuel Peretsman to a HIFU technical ...
Breaking Biology Technology: