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UC health news: molecular pathway may predict chemotherapy effectiveness
Date:8/31/2007

ff again, says Reed. This suggests that its not just loss of RB that affects therapy responseit could be changes at various steps in cellular signaling that result in different outcomes.

The traditional way of thinking of cancerone cancer gene to treat and youre doneis obviously not the best approach to treating this disease, he adds. These are complex, overlapping molecular pathways. Dissecting them and determining how to use that information to apply combinations of chemotherapeutic agents will allow for individualization of therapy.

Next year, Reed and his colleagues expect to begin testing the RB tumor suppressor in human tumor tissue samples from the UC Thoracic Tumor Registry and compare them to patients with known outcomes.

According to the American Cancer Society, more than 213,000 Americans will be diagnosed with lung cancer in 2007. Because most people are diagnosed late, the five-year survival rate is only 14 percentcompared with 86 percent for breast cancer, 61 percent for colon cancer and 96 percent for prostate cancer.


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Contact: Amanda Harper
amanda.harper@uc.edu
513-558-4657
University of Cincinnati
Source:Eurekalert

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