Navigation Links
UC health news: molecular pathway may predict chemotherapy effectiveness
Date:8/31/2007

CINCINNATIA common molecular pathway could help physicians predict which lung cancer patients will benefit from chemotherapy drugs, according to new research from a multidisciplinary team at the University of Cincinnati (UC).

Known as the retinoblastoma (RB) tumor suppressor, this fundamental molecule regulates cell proliferation in the body. Research has shown that the RB pathway is either entirely inactive or altered in most human cancers. Scientists are beginning to use its actions as a biomarker for how tumors will respond to different therapies.

Michael Reed, MD, and his UC colleagues found that turning off the RB pathway in lung cancer cells resulted in an altered response to chemotherapy agents and more cancer cell death. They report their findings in the September 2007 issue of the journal Cancer Research.

Dissecting the RB pathway will help us better understand how chemotherapy works and predict which patients might benefit from therapy and which ones wont, explains Reed, assistant professor of surgery at UC and a thoracic surgeon at University Hospital.

As pathways are further defined, we could choose agents that are targeted to an individual tumors molecular characteristics, he adds.

A previous UC study, published in the January 2007 issue of the Journal of Clinical Investigation, showed that when this pathway is disrupted or shut off in breast cancer, the tumor resists anti-estrogen drugs and the cancer continues to grow in spite of the therapy.

For this laboratory study, Reeds team shut off the RB pathway in human non-small cell lung cancer cells and exposed them to chemotherapy agents representative of those currently used to treat lung cancer patients.

Their results showed that when RB was turned off, the cancer cells continued to divide, but became more susceptible to the drugs, so the tumors stopped growing.

But the minute you take away the chemotherapy, the cells take off again, says Reed. This suggests that its not just loss of RB that affects therapy responseit could be changes at various steps in cellular signaling that result in different outcomes.

The traditional way of thinking of cancerone cancer gene to treat and youre doneis obviously not the best approach to treating this disease, he adds. These are complex, overlapping molecular pathways. Dissecting them and determining how to use that information to apply combinations of chemotherapeutic agents will allow for individualization of therapy.

Next year, Reed and his colleagues expect to begin testing the RB tumor suppressor in human tumor tissue samples from the UC Thoracic Tumor Registry and compare them to patients with known outcomes.

According to the American Cancer Society, more than 213,000 Americans will be diagnosed with lung cancer in 2007. Because most people are diagnosed late, the five-year survival rate is only 14 percentcompared with 86 percent for breast cancer, 61 percent for colon cancer and 96 percent for prostate cancer.


'/>"/>
Contact: Amanda Harper
amanda.harper@uc.edu
513-558-4657
University of Cincinnati
Source:Eurekalert

Related biology news :

1. Chemists create Superbowl molecule; May lead to better health
2. New push for public health, AIDS spending at African Union summit
3. Scientists collaborate to assess health of global environment
4. Highly adaptable genome in gut bacterium key to intestinal health
5. Genetically modified rice in China benefits farmers health, study finds
6. How the environment could be damaging mens reproductive health
7. BioMed Central welcomes the new National Institutes of Health public access policy
8. OneWorld Health drug receives Orphan designation from U.S. and European regulatory agencies
9. Mutation in clams protects against paralytic shellfish poisoning but raises human health risk
10. Health costs soar as 60 million Americans classed as obese
11. Study of energy and health in Africa focuses spotlight on charcoal and forest management
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2016)... , June 20, 2016 Securus Technologies, ... technology solutions for public safety, investigation, corrections and ... prisons involved, it has secured the final acceptance ... facilities for Managed Access Systems (MAS) installed. Furthermore, ... facilities to be installed by October, 2016. MAS ...
(Date:6/9/2016)... -- Perkotek an innovation leader in attendance control systems is proud to announce the introduction ... to make sure the right employees are actually signing in, and to even control ... ... ... ...
(Date:6/3/2016)... LONDON , June 3, 2016 /PRNewswire/ ... Transport Management) von Nepal ... ,Angebot und Lieferung hochsicherer geprägter Kennzeichen, einschließlich ... weltweit führend in der Produktion und Implementierung ... an der Ausschreibung im Januar teilgenommen, aber ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016   Boston Biomedical ... novel compounds designed to target cancer stemness pathways, ... been granted Orphan Drug Designation from the U.S. ... of gastric cancer, including gastroesophageal junction (GEJ) cancer. ... designed to inhibit cancer stemness pathways by targeting ...
(Date:6/23/2016)... 2016 A person commits a crime, and the ... track the criminal down. An outbreak of foodborne ... Administration (FDA) uses DNA evidence to track down the bacteria ... far-fetched? It,s not. The FDA has increasingly used a complex, ... foodborne illnesses. Put as simply as possible, whole genome sequencing ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, Inc. ... test has received AOAC Research Institute approval 061601. , “This is another AOAC-RI ... stated Bob Salter, Vice President of Regulatory and Industrial Affairs. “The Peel Plate ...
(Date:6/23/2016)... -- The Biodesign Challenge (BDC), a university competition that asks ... systems and biotechnology, announced its winning teams at the ... York City . The teams, chosen ... MoMA,s Celeste Bartos Theater during the daylong summit. Keynote ... of architecture and design, and Suzanne Lee , ...
Breaking Biology Technology: