Navigation Links
UC-developed technology to assist research and genetic drug delivery
Date:3/24/2010

Techulon, Inc., and UC sign worldwide exclusive license agreements to manufacture and sell novel reagents used for research and therapeutic delivery of nucleic acids.

Techulon, Inc., a life sciences company, has signed worldwide exclusive license agreements with the University of Cincinnati to manufacture and sell novel transfection reagents used for research and therapeutic delivery of nucleic acids. The licenses cover a family of new molecules invented by Theresa M. Reineke while she was a faculty member in the Chemistry Department of the McMicken College of Arts & Sciences and described in two patent applications filed by UC.

"The polymeric transfection agents we have licensed from the University of Cincinnati are an exact fit for our business," states Frank Akers, president of Techulon. "Our ionic biopolymer expertise and infrastructure allow us to bring products to market almost immediately. Our first product, Glycofect, is especially effective in transfecting DNA into cells because of its low toxicity and efficiently induced transgene expression. These qualities make Glycofect especially suitable for sensitive and difficult-to-transfect cell lines or primary cells."

Marketed under the name of Glycofect Transfection Reagent, the new polymer-based formulations demonstrate unparalleled efficacy for delivering genetic materials into a variety of cell types for health-related research and drug development.

In contrast to currently used lipid-based transfection reagents that dominate a growing $100 million market, Techulon's products are based on novel carbohydrate polymer structures invented by Reineke, now an associate professor of chemistry at Virginia Tech.

"This new class of polymers can deliver DNA research reagents and therapeutics into a high number of cells and tissues types without causing cell damage or death," Reineke says. "After cellular delivery, the glycopolymers degrade and release their DNA cargo to perform its biological function without toxic side effects."

"We intend to expand our transfection reagent offerings, plus we have sublicenses available for companies needing a highly efficient vector with low toxicity to aid in their drug discovery," says Akers. "Techulon has strong developmental and synthetic capabilities headed up by Joshua Bryson, who studied under world-renowned biomaterials researcher Theresa Reineke at the University of Cincinnati. Techulon will work in partnerships to tailor our delivery vehicles for optimal effectiveness of novel genetic tools and drugs."

Bryson, principal scientist at Techulon, adds, "The exceptional delivery, high gene expression, and low toxicity of GlycofectTM are particularly evident in primary cells. This is of great benefit to biological and medical research because current transfection reagents do not work well with primary cells and these cell types are very costly and difficult to obtain."

GlycofectTM has been sampled to a number of medical research laboratories that have identified a broad spectrum of applications. In some cases, Techulon is cooperating with researchers to tailor the GlycofectTM formulations to optimize results for a variety of applications including siRNA delivery. GlycofectTM will be available for purchase as a transfection reagent for research applications on April 1, 2010. Techulon also plans to sublicense GlycofectTM for therapeutic development.


'/>"/>

Contact: Wendy Beckman
wendy.beckman@uc.edu
513-556-1826
University of Cincinnati
Source:Eurekalert  

Related biology news :

1. Yale scientists use nanotechnology to fight E. coli
2. Voice Biometrics Gains Traction as Most Accurate and Convenient Technology to Secure Customer Privacy
3. M2SYS Partners with SecuGen Corporation to Support Market Leading Hamster Plus Fingerprint Reader with Auto-On Technology
4. Silicon Valley Technology Leaders LaserCard Corporation and Tesla Motors Sign LaserPass Secure Access Deal
5. Nanotechnology: Whats that?
6. UCs NIH grant brings technology from outer space to playgrounds
7. BIO-key(R) International to Showcase Deployed Biometric Security Applications at 2007 Biometric Technology Expo
8. Cogent Systems and Northrop Grumman Reach Agreement to Settle Automated Fingerprint Identification Technology Suit and Create Strategic Alliance
9. UCLA/VA partners with ASU to advance biosensor technology for urinary tract infections
10. Herr receives Heinz Award for Technology, the Economy and Employment
11. Singapore National Science and Technology Awards
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UC-developed technology to assist research and genetic drug delivery
(Date:2/8/2017)... About Voice Recognition Biometrics Voice recognition biometrics ... a stored voiceprint template. Acoustic features of an ... are compared to distinguish between individual voices. Voice ... PCs already have a microphone and can authenticate ... are most likely to be deployed in telephone-based ...
(Date:2/8/2017)... 2017 Report Highlights The global ... $8.3 billion in 2016 at a compound annual growth ... Report Includes - An overview of the global market ... data from 2015 and 2016, and projections of compound ... the market on the basis of product type, source, ...
(Date:2/6/2017)... 2017 According to Acuity Market Intelligence, ... authorities to continue to embrace biometric and digital ... Automated Border Control (ABC) eGates and 1436 Automated ... than 163 ports of entry across the globe. ... a combined CAGR of 37%. APC Kiosks reached ...
Breaking Biology News(10 mins):
(Date:2/22/2017)... Fort Washington, PA (PRWEB) , ... ... ... The Omnia-Prova Education Collaborative (TOPEC), the leading medical education provider of ... Accreditation with Commendation by the Accreditation Council for Continuing Medical Education (ACCME). ...
(Date:2/22/2017)... Dublin - Research ... Crop Protection (Bio-Pesticide) Market-By Type, By Application, By End User, By ... offering. ... Biological Crop Protection Market is forecasted to grow at a CAGR ... biopesticide or biological crop protection market is driven by the surging ...
(Date:2/22/2017)... ... February 22, 2017 , ... Pharma and biotech ... as European director. Operating from Pennside’s Zurich headquarters, Pennside Partners, GmbH, Mr. Perkins ... Pennside after more than a decade with leading market research firm, GfK. He ...
(Date:2/21/2017)... - SQI Diagnostics Inc. ("SQI" or the "Company") (TSX-V: SQD; OTCQX: ... months ended December 31, 2016. SQI is ... company that develops and commercializes proprietary technologies and products for ... ... milestones achieved in fiscal 2016," said Andrew Morris , ...
Breaking Biology Technology: