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UC-developed technology to assist research and genetic drug delivery
Date:3/24/2010

Techulon, Inc., and UC sign worldwide exclusive license agreements to manufacture and sell novel reagents used for research and therapeutic delivery of nucleic acids.

Techulon, Inc., a life sciences company, has signed worldwide exclusive license agreements with the University of Cincinnati to manufacture and sell novel transfection reagents used for research and therapeutic delivery of nucleic acids. The licenses cover a family of new molecules invented by Theresa M. Reineke while she was a faculty member in the Chemistry Department of the McMicken College of Arts & Sciences and described in two patent applications filed by UC.

"The polymeric transfection agents we have licensed from the University of Cincinnati are an exact fit for our business," states Frank Akers, president of Techulon. "Our ionic biopolymer expertise and infrastructure allow us to bring products to market almost immediately. Our first product, Glycofect, is especially effective in transfecting DNA into cells because of its low toxicity and efficiently induced transgene expression. These qualities make Glycofect especially suitable for sensitive and difficult-to-transfect cell lines or primary cells."

Marketed under the name of Glycofect Transfection Reagent, the new polymer-based formulations demonstrate unparalleled efficacy for delivering genetic materials into a variety of cell types for health-related research and drug development.

In contrast to currently used lipid-based transfection reagents that dominate a growing $100 million market, Techulon's products are based on novel carbohydrate polymer structures invented by Reineke, now an associate professor of chemistry at Virginia Tech.

"This new class of polymers can deliver DNA research reagents and therapeutics into a high number of cells and tissues types without causing cell damage or death," Reineke says. "After cellular delivery, the glycopolymers degrade and release their DNA cargo to perform it
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Contact: Wendy Beckman
wendy.beckman@uc.edu
513-556-1826
University of Cincinnati
Source:Eurekalert  

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