Navigation Links
UC San Diego researchers identify potential new drug candidates to combat 'bird flu'
Date:7/2/2008

ng Lily S. Cheng, co-first author; Don Xu; Wilfred Li; and Peter W. Arzberger.

The study, published in the Journal of Medicinal Chemistry, builds on prior work that captured the nanosecond-by-nanosecond movements of a protein called neuraminidase 1 (or N1), needed by the avian flu virus to spread infection to new cells. To help reveal the often-spasmodic motion of proteins, scientists work with molecular dynamics codes that simulate their movements as they obey the fundamental laws of physics. Such is the complexity of the mathematical calculations needed for these simulations that scientists often require the use of supercomputers. In this case, the researchers ran their data through a molecular dynamics program called NAMD - developed at the University of Illinois at Urbana-Champaign - on supercomputers at SDSC and the National Center for Supercomputing Applications in Illinois.

Some surprising details emerged as the scientists watched the protein gyrate and wiggle over time. In particular, one region dubbed a "hot pocket" appeared to be quite dynamic and flexible. Amaro said the topology of this region and the amino acids linking the pocket are significantly different from what the scientists previously observed in a static image of the protein's crystal structure.

"Crystal structures are very important," she said. "They give us a real picture of the protein. But it's just one picture."

Over the past decade or so, scientists have come to realize that the sometimes colorful structures gleaned from standard crystallography studies are limited. Instead of a still-life painting, proteins act more like a moving picture, constantly twitching and jiggling, making the goal of finding a specific inhibitor somewhat daunting. It's somewhat like a baseball pitcher attempting to throw strikes to a catcher who's doing handsprings behind home plate.

Molecular dynamics simulations already have proved their value for other dr
'/>"/>

Contact: Warren R. Froelich
froelich@sdsc.edu
858-822-3622
University of California - San Diego
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Glowing films developed by UC San Diego chemists reveal traces of explosives
2. UC San Diego researchers eliminate drug discovery bottleneck
3. Biologists at UC San Diego identify key protein in cells self-eating function
4. San Diego Harbor Police Deploy BIO-key(R) Automated Vehicle Location System
5. UC San Diego begins trading greenhouse gas credits on Chicago Climate Exchange
6. Experimental Biology 2008 meets in San Diego April 5-9
7. UC-San Diego Engineering Honor Society wins most outstanding chapter award
8. UC San Diego physicists tackle knotty puzzle
9. Texas A&M researchers develop tool to study complex clusters of genes
10. Weekends slow weight loss, researchers find
11. Researchers coat titanium with polymer to improve integration of joint replacements
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UC San Diego researchers identify potential new drug candidates to combat 'bird flu'
(Date:7/28/2014)... showing signs of damage from the Deepwater Horizon oil spill ... Gulf of Mexico. The discovery was made by a team ... University. A paper describing this work and additional impacts of ... be published during the last week of July 2014 in ... the National Academy of Sciences . , "The footprint of ...
(Date:7/28/2014)... people in the United States have a circulatory problem ... be painful and may even require surgery in serious ... wasting and, in turn, limb amputation. , At The ... Medical School, scientists tested a non-surgical preventative treatment in ... associated with increased blood circulation. Their proof-of-concept study ...
(Date:7/28/2014)... pinpointed a mechanism in part of the brain that is ... to both type 1 and type 2 diabetes. The findings ... of the National Academies of Sciences . , "We,ve ... part of the hypothalamus known as the ventromedial nucleus ... levels in the blood," said lead author Sabrina Diano, professor ...
Breaking Biology News(10 mins):Impact of Deepwater Horizon oil spill on coral is deeper and broader than predicted 2Scientists discover genetic switch that can prevent peripheral vascular disease in mice 2Glucose 'control switch' in the brain key to both types of diabetes 2
... (UB) has analysed which facial features our brain examines to ... maximum amount of information possible from each face and according ... in the first place, the eyes and then the shape ... study, undertaken by researcher Matthias S. Keil from the Basic ...
... 20 July 2009: Research at the University of Liverpool has ... protect buildings from earthquakes. The seismic waves produced ... and surface waves which travel across it. The new technology ... damaging and responsible for much of the destruction which follows ...
... has a long history of healing power. Its ability to heal ... back as the 10th century. Legend has it that Cleopatra used ... aloe vera was first recognized the 1930s to heal radiation burns. ... heal sunburn, minor cuts, skin irritation, and many other ailments. Recently, ...
Cached Biology News:Our brain looks at eyes first to identify a face 2Our brain looks at eyes first to identify a face 3'Invisibility cloak' could protect against earthquakes 2Healing power of aloe vera proves beneficial for teeth and gums, too 2
(Date:7/29/2014)... 2014 Genera Energy Inc. ... innovation and supply chain advancements, has announced the ... Energy Grange™ and Supply ASSURE™. Both systems ... testing aimed at consolidating and simplifying the entire ... farmers and feedstock end users. , “Through the ...
(Date:7/29/2014)... 29, 2014 Quorum Review IRB, ... been awarded accreditation by the International Association ... Lean Six Sigma Deployment Program. The citation recognizes ... performance. , Quorum’s Lean Six Sigma program was ... Program designation. The designation is a public statement ...
(Date:7/29/2014)... Aromas, California (PRWEB) July 29, 2014 ... Droidles is a next generation approach to robotics. What ... toys is patent pending technology that allows them to ... programs, all wirelessly over the internet. , “The invention ... "We're giving the little Droidles a life of their ...
(Date:7/29/2014)... Wendel – recipient of a Regional Top Doctor Award for ... Surgeon Specialists for Nashville, TN – has released a new ... Hydration Booster, Retexturing Night Crème, and Anti-aging C Complex, all ... radiant appearance while protecting them from the sun’s harmful UV ... Dr. J. J. Wendel Plastic Surgery, we have developed a ...
Breaking Biology Technology:Genera Energy Introduces Proprietary Feedstock Management Systems 2Genera Energy Introduces Proprietary Feedstock Management Systems 3Genera Energy Introduces Proprietary Feedstock Management Systems 4Quorum Review IRB Accredited by IASSC for Lean Six Sigma Deployment Program 2Quorum Review IRB Accredited by IASSC for Lean Six Sigma Deployment Program 3Droidles, the Social Network of Robots and Open Source Platform for the Internet of Things, Launches for Crowd Funding on IndieGoGo.com 2Dr. J. J. Wendel Launches New Line of Skin Care Products 2
... , SAN DIEGO, Aug. 6 SEQUENOM, Inc. ... ended June 30, 2009. , , (Logo: http://www.newscom.com/cgi-bin/prnh/20040415/SQNMLOGO ) , ... Total revenue for the second quarter of 2009 was $9.2 million, ... the comparable period last year was primarily due to softness in capital expenditure ...
... ... Launch Of Its New And Improved Website. The New Site Provides Users With A ... Functionality And Navigation. The Site Also Offers An Expanded Service Description For Each Of ... ...
... , , LOS ANGELES, Aug. 6 ... an 82 year-old Chinese female immigrant who suffered Stevens-Johnson Syndrome/Toxic Epidermal ... Defendant, an osteopathic physician and registered pharmacist, prescribed it to her ... did not have gout. The doctor claimed that she told ...
Cached Biology Technology:SEQUENOM Reports Second Quarter 2009 Financial Results and Highlights 2SEQUENOM Reports Second Quarter 2009 Financial Results and Highlights 3SEQUENOM Reports Second Quarter 2009 Financial Results and Highlights 4SEQUENOM Reports Second Quarter 2009 Financial Results and Highlights 5SEQUENOM Reports Second Quarter 2009 Financial Results and Highlights 6SEQUENOM Reports Second Quarter 2009 Financial Results and Highlights 7SEQUENOM Reports Second Quarter 2009 Financial Results and Highlights 8SEQUENOM Reports Second Quarter 2009 Financial Results and Highlights 9SEQUENOM Reports Second Quarter 2009 Financial Results and Highlights 10One of the Nation's Leading Analytical Testing Laboratories is Now Easier to Access -- Pace Analytical Launches New Web Site to Showcase Its Three Business Divisions 2The Law Offices of Brian D. Witzer Wins 6+ Million Dollar Verdict 2
WIF-1 (N-20)...
... Strong reactivity with rat (100%), ... guinea pig (48%). Slight ... Specificity confirmed by Western blot ... rat Gia-1, Gia-2, rat Gia-3, ...
VEGF Receptor-2, phospho-specific (Tyr996)...
IgG2b, k APC clone A95-1, Isotype Rat IgG2b, kappa, 0.1 mg ....
Biology Products: