Navigation Links
UC San Diego researchers identify potential new drug candidates to combat 'bird flu'
Date:7/2/2008

As the specter of a worldwide outbreak of avian or "bird flu" lingers, health officials recognize that new drugs are desperately needed since some strains of the virus already have developed resistance to the current roster of anti-flu remedies.

Now, a team of UC San Diego scientists - with the help of resources at the San Diego Supercomputer Center (SDSC), also at UC San Diego - have isolated more than two dozen promising and novel compounds from which new "designer drugs" might be developed to combat this disease. In some cases, the compounds appeared to be equal or stronger inhibitors than currently available anti-flu remedies.

"If those resistant strains begin to propagate, then that's when we're going to be in trouble, because we don't have any anti-virals active against them," said Rommie Amaro, a postdoctoral fellow in chemistry at UC San Diego. "So, we should have something as a backup, and that's exactly why we're working on this."

Avian flu has provoked considerable concern since humans have little or no immune protection against the virus. While flu vaccines are being developed, it could take up to nine months for an effective vaccine to be developed against any new strains, and could still be rendered ineffective if any new strains arise over that time. Should the virus gain the capacity to spread from person to person, the result could be a worldwide outbreak or pandemic.

"In light of the urgency to find drugs to combat this virus, we're hopeful that our results will assist in that effort," said J. Andrew McCammon, holder of the Joseph Mayer Chair of Theoretical Chemistry at UC San Diego and a Howard Hughes Medical Institute Investigator.

Also participating in this study were researchers from the National Biomedical Computation Resource (NBCR), part of the Center for Research on Biological Systems and the California Institute for Telecommunications and Information Technology at UC San Diego, includi
'/>"/>

Contact: Warren R. Froelich
froelich@sdsc.edu
858-822-3622
University of California - San Diego
Source:Eurekalert  

0

GOOD

Page: 1 2 3 4

Related biology news :

1. Glowing films developed by UC San Diego chemists reveal traces of explosives
2. UC San Diego researchers eliminate drug discovery bottleneck
3. Biologists at UC San Diego identify key protein in cells self-eating function
4. San Diego Harbor Police Deploy BIO-key(R) Automated Vehicle Location System
5. UC San Diego begins trading greenhouse gas credits on Chicago Climate Exchange
6. Experimental Biology 2008 meets in San Diego April 5-9
7. UC-San Diego Engineering Honor Society wins most outstanding chapter award
8. UC San Diego physicists tackle knotty puzzle
9. Texas A&M researchers develop tool to study complex clusters of genes
10. Weekends slow weight loss, researchers find
11. Researchers coat titanium with polymer to improve integration of joint replacements

Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UC San Diego researchers identify potential new drug candidates to combat 'bird flu'
UC San Diego researchers identify potential new drug candidates to combat 'bird flu'
(Date:11/26/2009)...essive antlers, red deer have been caught in the h...rs are much more than decorative. They are lethal ...ohn Currey, from The University of York, UK, has b... for over half a century and has become fascinated...long-standing collaboration with Tomas Landete-Cas...
(Date:11/26/2009)...ember 26, 2009) Whitehead researchers have develo...o pinpoint specific genes and proteins used by pat... In most human cell cultures genes are present in ...from the mother. Gene inactivation by mutation is ...ctivated, the second copy usually remains active a...
(Date:11/25/2009)...tists at the California Institute of Technology (C...tion-like behavior in the fruit fly, Drosophila m...evant to the relationship between the neurotransmi...disorder (ADHD), are described in the December iss...rain contains only about 20,000 neurons and has lo...
Breaking Biology News(10 mins):Tough yet stiff deer antler is materials scientist's dream 2Knockouts in human cells point to pathogenic targets 2Caltech scientists find emotion-like behaviors, regulated by dopamine, in fruit flies 2Caltech scientists find emotion-like behaviors, regulated by dopamine, in fruit flies 3Caltech scientists find emotion-like behaviors, regulated by dopamine, in fruit flies 4Aldrichimica Acta Ranked First in Organic Chemistry by Impact Factor 13555 1Aldrichimica Acta Ranked First in Organic Chemistry by Impact Factor 13555 2Service Corporation International Declares Quarterly Cash Dividend 54485 1Service Corporation International Declares Quarterly Cash Dividend 54485 2Service Corporation International Declares Quarterly Cash Dividend 54485 3Exercise May Help in Leukemia Recovery 54483 1Exercise May Help in Leukemia Recovery 54483 2
...harks are known to have a keen sense of smell, whi...owever, according to new research from Boston Univ...their noses to locate prey; they also need their s...ine. The lateral line is an organ used by all fish...nd vibration in the surrounding water. According t...
...ew research conducted at the Uniformed Services Un...t it may be possible to develop a vaccine that pro... HIV is extremely variable, so an effective vaccin...reactive antibodies that will neutralize multiple ...ction of truly broad-spectrum neutralizing antibod...
...n the wake of the U.S. government’s watershed deci...ned" under the Endangered Species Act, the Wildlif...nitiative to save the Earth’s largest terrestrial ...ut the receding sea ice habitat that may drastical...ect named "Warm Waters for Cool Bears," WCS will u...
Other Biology News:New research shows sharks use their noses and bodies to locate smells 2New research shows sharks use their noses and bodies to locate smells 3Want to save polar bears? Follow the ice 2Want to save polar bears? Follow the ice 3
(Date:11/24/2009)...w York investment bank KTA Capital,s client Neuren...7 mil convertible note private placement with a U....as arranged by KTA Capital as Neuren,s exclusive p... New York (PRWEB) November 23, 2009 -- The ind... ("KTA Capital") has announced that its ...
(Date:11/24/2009)...re-FirstCall/--Sigma-AldrichCorporation(Nasdaq: SI...day,December1stat1:45PMGMTinLondon,7:45AMUS/CST.In...heInternetavailableat http://inve s tor.sig m ...toaccessthisfile. ,, AboutSigma-Aldrich: Sig...mpany.Itschemicalandbiochemicalproductsandkitsareu...
(Date:11/24/2009)...RNewswire-FirstCall/--NeurogesX,Inc.(Nasdaq: NGSX ...ommercializingnovelpainmanagementtherapies,announc...veOfficer,isscheduledtopresentatthe21stAnnualPiper...09atTheNewYorkPalaceHotelinNewYork,NewYork. ,, ...r,willbeavailabletorespondtoquestionsduringthepres...
(Date:11/24/2009)...asbeenmetforpatientswithadvanced-stage,orrecurrent...wire-FirstCall/-AEternaZentarisInc.(NASDAQ: AEZS ;...panyfocusedonendocrinetherapyandoncology,todayanno...rgetedcytotoxicpeptideconjugate,AEZS-108(formerlyA...lcancer.Inapersonalizedhealthcareapproach,thestudy...
Breaking Biology Technology:KTA Capital Arranges an AU$6.7 Million Private Placement by Neuren Pharmaceuticals 2NeurogesX to Present at Piper Jaffray Health Care Conference 2NeurogesX to Present at Piper Jaffray Health Care Conference 3AEterna Zentaris Announces Positive Results for Phase 2 Study with LHRH-Receptor Targeted Cytotoxic Conjugate AEZS-108 in Endometrial Cancer 2AEterna Zentaris Announces Positive Results for Phase 2 Study with LHRH-Receptor Targeted Cytotoxic Conjugate AEZS-108 in Endometrial Cancer 3AEterna Zentaris Announces Positive Results for Phase 2 Study with LHRH-Receptor Targeted Cytotoxic Conjugate AEZS-108 in Endometrial Cancer 4
... Merge eFilm , the Milwaukee-based medical imagi...chnologies Inc., continued to build momentum leadi...ara and subsidiary eMed by posting net sales of ju..., ,That,s a 22 percent increase over first quarter...et sales in the fourth quarter of 2004. , ,Sales o...
...your annual review date is approaching and you,re ...ming your way. , ,You know you have to have a grea...your pay-raise proposal. You also know that dollar...rammed after several years of heart-rending pleas ...ay-me-more arguments. , ,So how can you create a p...
...Wis. Donato Diorio would like to toss the buying...n occupied by buttonhooks and buggy whips. , ,What...oadlook Technologies might have just the silver b... suite Profiler, Eclipse and Contact Magnet a sa...y can mine real-time information on the Internet a...
Other Biology Technology:Merge eFilm earnings jump precedes planned merger 2Merge eFilm earnings jump precedes planned merger 3Want a raise? Ten best midwest tech salary-increase pitches 2Want a raise? Ten best midwest tech salary-increase pitches 3Want a raise? Ten best midwest tech salary-increase pitches 4Want a raise? Ten best midwest tech salary-increase pitches 5Broadlook narrows search for sales leads with software 2Broadlook narrows search for sales leads with software 3
RDF (R106-05) from European Collection of Cell Cultures (ECACC)
...The Brownlee Precision Model 440 incorporates four...rcuitry in a friendly easy-to-use instrument. Each...er, an 8-pole Bessel lowpass filter, a highpass fi...ols. A control knob sets the amplifier parameters ...
REK (R102-05) from European Collection of Cell Cultures (ECACC)
PCAEC (P300-05) from European Collection of Cell Cultures (ECACC)
Biology Products: