Navigation Links
UC San Diego engineer provides insights to decades-old DNA squabble
Date:7/31/2009

f variables in the system by eliminating the variables that are not important at the length and time scales of interest. "This research emphasizes how engineering tools can provide new insights into biology," he added.

"When we talk about cancer and its link to abnormal gene regulation, we have to ask the question why are these genes misfiring? In the end, it boils down to the protein machinery that makes up and regulates chromatin," he explained. "You could have mutations in the oncogenic or tumor suppressor genes that lead to cancer or you could have abnormalities in the proteins that regulate chromatin around these genes leading to cancer."

The next step for Arya and his team is to study the mechanisms by which chromatin is regulated, and how those lead to genes being switched "on" and "off," genes being repaired in response to mutations, and genes being replicated during cell division. Arya believes that a molecular-level understanding of such mechanisms could lead to the development of better drugs that will directly target the chromatin around abnormally regulated genes to correct their activity. "In fact, there are already drugs being developed called HDIs (histone deacetylase inhibitors) that can modulate structure of chromatin around oncogenic genes so as to inhibit cancer progression, though their exact mechanisms are not fully known," Arya said.

"The scientific community is quite fascinated by DNA and they tend to forget that DNA is rarely present in its naked double-stranded helix form in higher organisms like humans, but that it is always associated with proteins in this complex aggregate we call chromatin," he added. "Undoubtedly, DNA codes for nearly all the proteins and RNAs manufactured inside our cells but how, when, and which genes are turned on and off is almost completely determined by the structure, dynamics, and chemical properties of chromatin. We now know how chromatin compacts and what its internal structu
'/>"/>

Contact: Andrea Siedsma
asiedsma@soe.ucsd.edu
858-822-0899
University of California - San Diego
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. UC San Diego physicists tackle knotty puzzle
2. UC-San Diego Engineering Honor Society wins most outstanding chapter award
3. Experimental Biology 2008 meets in San Diego April 5-9
4. UC San Diego begins trading greenhouse gas credits on Chicago Climate Exchange
5. San Diego Harbor Police Deploy BIO-key(R) Automated Vehicle Location System
6. Biologists at UC San Diego identify key protein in cells self-eating function
7. UC San Diego researchers eliminate drug discovery bottleneck
8. Glowing films developed by UC San Diego chemists reveal traces of explosives
9. UC San Diego researchers identify potential new drug candidates to combat bird flu
10. UC San Diego launches Institute of Engineering in Medicine to accelerate health care tech
11. UC San Diego researchers could help US military thwart explosive threats
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UC San Diego engineer provides insights to decades-old DNA squabble
(Date:12/5/2014)... VIEW, Calif. , Dec. 4, 2014 /PRNewswire/ ... safety has boosted investments in new testing and ... has also given rise to a range of ... by the requirements of Generation Y, which is ... technologies. As a result, product development strategies of ...
(Date:12/3/2014)... As part of our commitment to offering ... to announce the release of a new reader that ... workforce data that they need. The Atlas ... existing readers. Many such devices have serious shortcomings when ... Older models force users to navigate numerous complicated steps ...
(Date:11/21/2014)... Wash. , Nov. 20, 2014 C-Labs ... for the Internet of Things (IoT), today announced the ... of chief operating officer. Previously a strategic advisor to ... finance, and operations. Mr. Traynor is based out of ... . He reports to Chris Muench , Chief ...
Breaking Biology News(10 mins):Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Inception Technologies to Release New Biometric Reader 2C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2
... at the Institute of Food Research, which is ... of virus-produced proteins that destroy bacterial cells to ... proteins that specifically target certain bacteria, and IFR ... difficile , a common and dangerous source of ...
... five-year grant is considered a long-term grant, Alan R. Templeton, PhD, ... in St. Louis, has managed to follow some of the species ... in his career he studied parthenogenesis, or virgin birth, in fruit ... "Drosophilia have fast generation times," he says, "but I studied ...
... ReportsnReports   announces it will carry Market Research Reports on ... Image-Guided Surgery)   in its store A. ... Cell Arrays) Trends & Global Forecast (2010-2015) ... key applications. It was valued at $2.6 billion in 2010 ...
Cached Biology News:Tuning natural antimicrobials to improve their effectiveness at battling superbugs 2Restoration as science: case of the collared lizard 2Restoration as science: case of the collared lizard 3Restoration as science: case of the collared lizard 4Restoration as science: case of the collared lizard 5Restoration as science: case of the collared lizard 6Restoration as science: case of the collared lizard 7Restoration as science: case of the collared lizard 8Restoration as science: case of the collared lizard 9ReportsnReports - Biochips Market, Nuclear Medicine Market, Medical Imaging Market Research 2ReportsnReports - Biochips Market, Nuclear Medicine Market, Medical Imaging Market Research 3ReportsnReports - Biochips Market, Nuclear Medicine Market, Medical Imaging Market Research 4ReportsnReports - Biochips Market, Nuclear Medicine Market, Medical Imaging Market Research 5
(Date:12/22/2014)... The Center for Professional Innovation ... training across the life sciences industry, has partnered with ... to provide the organization's members with discounted classroom courses, ... the more than 350 sessions across 80 course titles. ... when registering for a public course at ...
(Date:12/22/2014)... 2014 GenomeDx Biosciences today announced that a ... a genomic test for prostate cancer, was able to ... by radical prostatectomy without adjuvant therapy. Although rapid metastasis ... using tumor genomics to identify these men who have ... important advance. The study has been published online ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 Fertility Associates ... Donor Egg Bank USA , a network of more ... Through this partnership, patients have fast access to a ... vitro fertilization, IVF . Fertility Associates of Memphis is ... this fertility treatment option. , Dr. William Kutteh ...
(Date:12/19/2014)... -- Naurex Inc., a biopharmaceutical company leveraging its unique ... central nervous system, today announced that Norbert Riedel ... at the 33 rd annual J.P. Morgan Healthcare ... p.m. PST on Tuesday, January 13, 2015, at the ... About Naurex Inc. ...
Breaking Biology Technology:CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3Naurex to Present at 33rd Annual J.P. Morgan Healthcare Conference 2
... Pharmaceuticals,Inc. (Nasdaq: VNDA ), a biopharmaceutical company ... candidates for central,nervous system disorders, today announced financial ... 30, 2008., Vanda reported research and development ... $3.8 million, compared to $5.5 million in the ...
... Identify Predisposition to Early Cardiovascular,Events in Asian Populations, ... (Amex: ILI ), announced today that Kenneth ... new research findings on,the genetics of cardiovascular disease ... which takes place from Oct. 31 -,Nov. 1, ...
... on the DBTSS, Pfam and PDB databases enable ,researchers to quickly ... ... 2008 -- OpenHelix today announced the availability of newly updated ... the Protein Databank (PDB). DBTSS is a public resource for ...
Cached Biology Technology:Vanda Pharmaceuticals Reports Third Quarter 2008 Results 2Vanda Pharmaceuticals Reports Third Quarter 2008 Results 3Vanda Pharmaceuticals Reports Third Quarter 2008 Results 4Vanda Pharmaceuticals Reports Third Quarter 2008 Results 5Vanda Pharmaceuticals Reports Third Quarter 2008 Results 6Vanda Pharmaceuticals Reports Third Quarter 2008 Results 7Vanda Pharmaceuticals Reports Third Quarter 2008 Results 8Vanda Pharmaceuticals Reports Third Quarter 2008 Results 9Vanda Pharmaceuticals Reports Third Quarter 2008 Results 10Interleukin Genetics to Present New Findings at the 11th Cardiovascular Genomics and Atherosclerosis Symposium 2Interleukin Genetics to Present New Findings at the 11th Cardiovascular Genomics and Atherosclerosis Symposium 3Interleukin Genetics to Present New Findings at the 11th Cardiovascular Genomics and Atherosclerosis Symposium 4Updated Online Tutorials for DBTSS, Pfam and PDB 2Updated Online Tutorials for DBTSS, Pfam and PDB 3
... quadrupole 1200L sets the new standard ... - incorporating the latest technologies and ... chromatography analytical needs. The Atmospheric ... Transmission Quadrupole Analyzer provide superior selectivity ...
Human GFR alpha-4 Affinity Purified Polyclonal Ab...
Human Siglec-9 Biotinylated Affinity Purified Pab...
Human MFRP MAb (Clone 291218)...
Biology Products: