Navigation Links
UC San Diego engineer provides insights to decades-old DNA squabble
Date:7/31/2009

aborators suggest that the structure of chromatin is actually a combination of both of these models.

Some researchers suggest that its structure is like a solenoid, where the chain of nucleosomes follows a helical path along the chromatin axis such that adjacent nucleosomes along the chain lie side by side on the chromatin fiber also and thus the linker DNA connecting the two needs to maintain a highly bent conformation. Other researchers suggest that chromatin has a zigzag structure where the nucleosome chain follows a zigzag path along the chromatin fiber such that adjacent nucleosomes on the chain actually lie on opposite sides of the fiber such that the linker DNA is straight. (The nucleosome is the basic unit of chromatin that consists of two turns of DNA wrapped around a protein spool).

Arya and his team have developed a very sophisticated model of chromatin that is computationally accessible yet detailed enough to provide insights into its structure and dynamics. By simulating this model under physiological conditions using fast computer algorithms, Arya has provided the first evidence that chromatin does not exist uniquely in solenoid or zigzag forms but rather exhibits a "heteromorphic" structure where both types of structures are in balance with each other. Arya's collaborators have developed an innovative experimental approach called Electron microscopy assisted nucleosome capture technique to corroborate Arya's findings.

"What we did was extract the most important features of DNA and the associated proteins in the model, using techniques called coarse-graining," Arya explained. "You cannot simulate something as large as a chromatin fiber containing tens of nucleosomes at molecular detail for periods of time longer than a few nanoseconds. That will not tell you much. You need to reduce the complexity of the system without sacrificing important details, which is exactly what we have done. We're trying to reduce the total number o
'/>"/>

Contact: Andrea Siedsma
asiedsma@soe.ucsd.edu
858-822-0899
University of California - San Diego
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. UC San Diego physicists tackle knotty puzzle
2. UC-San Diego Engineering Honor Society wins most outstanding chapter award
3. Experimental Biology 2008 meets in San Diego April 5-9
4. UC San Diego begins trading greenhouse gas credits on Chicago Climate Exchange
5. San Diego Harbor Police Deploy BIO-key(R) Automated Vehicle Location System
6. Biologists at UC San Diego identify key protein in cells self-eating function
7. UC San Diego researchers eliminate drug discovery bottleneck
8. Glowing films developed by UC San Diego chemists reveal traces of explosives
9. UC San Diego researchers identify potential new drug candidates to combat bird flu
10. UC San Diego launches Institute of Engineering in Medicine to accelerate health care tech
11. UC San Diego researchers could help US military thwart explosive threats
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UC San Diego engineer provides insights to decades-old DNA squabble
(Date:9/21/2014)... of children with autism are significantly less likely to ... than the mothers of children who are developing normally, ... Institute has found. , Low iron intake was associated ... child if the mother was 35 or older at ... suffered from metabolic conditions such as obesity hypertension or ...
(Date:9/21/2014)... MA -- In recent years, new strains of bacteria ... Each year, these superbugs, including drug-resistant forms of tuberculosis ... and kill at least 23,000. Despite the urgent need ... classes of antibiotics in the past decade. , MIT ... these superbugs. Using a gene-editing system that can disable ...
(Date:9/19/2014)... the Jimmy Durante of dinosaurs a newly ... The new dinosaur, named Rhinorex condrupus ... Brigham Young University, lived in what is now ... Late Cretaceous period. , Rhinorex, which translates roughly ... close relative of other Cretaceous hadrosaurs like Parasaurolophus ...
Breaking Biology News(10 mins):Mothers of children with autism less likely to have taken iron supplements 2Battling superbugs 2Battling superbugs 3Battling superbugs 4New hadrosaur noses into spotlight 2
... that lives in rushing streams and waterfalls in east-central China ... flowing water by communicating ultrasonically, scientists reported March 16 in ... ultrasounds are made possible by the presence of an ear ... points out an elegant and novel solution to the problem ...
... the evolution of Earth's first animals will have to ... conditions, according to a new study by Indiana University ... Proceedings of the National Academy of Sciences. , ... the last 12 years, mainly by paleontologists working in ...
... of an event before it even happens. A team at UCL ... us before we have seen what we will remember. , ... indicate that the brain can actually get into the 'right frame ... our best if the brain is active not only at the ...
Cached Biology News:Frog’s ear canal may provide insights for understanding human hearing loss 2Frog’s ear canal may provide insights for understanding human hearing loss 3Embryos tell story of Earth's earliest animals 2Embryos tell story of Earth's earliest animals 3You will remember this 2
(Date:9/20/2014)... 20, 2014 MediVet America ... a groundbreaking surgery at the specialized Wolvega Horse Clinic. ... digital flexor tendon was ruptured 90% and her deep ... is a death sentence for a horse. , The ... cell treatments . This revolutionary regenerative option for ...
(Date:9/19/2014)... yields to disease risks, the biological characteristics people care ... as for heightthe textbook example of a complex traitattributes ... by multiple genetic and environmental influences, making it challenging ... genes, geneticists typically mate two individuals that differ in ... mouseand then study their descendents, looking for genes that ...
(Date:9/19/2014)... to move data would consume much less power ... as chips, transistor counts rise. , Of the ... emitters, modulators, and detectors emitters are the ... optical chips is molybdenum disulfide (MoS2), which has ... atom-thick layer. Other experimental on-chip light emitters have ...
(Date:9/19/2014)... , Sept. 19, 2014  An entire month is ... inherited neuropathies – Charcot-Marie-Tooth disease (CMT) – a debilitating ... causing extreme muscle atrophy, weakness, and foot and hand ... and millions worldwide. CMT is a progressive disease, and ... legs, requiring mobility devices such as leg braces, wheelchairs ...
Breaking Biology Technology:World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 2World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 3Want to link genes to complex traits? Start with more diversity 2Toward optical chips 2Toward optical chips 3September is Charcot-Marie-Tooth (CMT) Awareness Month - Scheduled events, activities and important partnerships announced throughout the month! 2
... discovered in 2004 at The University of Manchester by Professor ... world,s most versatile materials, and is already being used in ... Researchers from the University are presenting the vast potential ... Science Exhibition which opens today (5 July 2010). ...
... 5, 2011 Cellectis bioresearch, a subsidiary of ... has received the "Most Innovative New Service 2011" ... service offering. TALENs(1) allow for customized gene modifications, ... and now affordable new tool. This prize was ...
... Generex Biotechnology Corporation (OTCBB: GNBT) ( www.generex.com ... Curt Weldon to assist in supporting the strategic ... press conference in New York City on March ... Congressman Weldon will source, evaluate, and introduce Generex ...
Cached Biology Technology:The wonders of graphene on display 2TALEN® Access by Cellectis Bioresearch Receives "Most Innovative New Service 2011" Award at Life Science Awards 2Generex Announces U.S. Congressman Curt Weldon, Co-Founder of the Congressional Diabetes Caucus, to Champion Generex Initiatives in Asia and North America 2Generex Announces U.S. Congressman Curt Weldon, Co-Founder of the Congressional Diabetes Caucus, to Champion Generex Initiatives in Asia and North America 3Generex Announces U.S. Congressman Curt Weldon, Co-Founder of the Congressional Diabetes Caucus, to Champion Generex Initiatives in Asia and North America 4
Complete cell culture media with cytokines...
8 different frozen tissues are mounted on positively charged glass slides...
Donor feline serum and plasma...
... These versatile vacuum cups provide flexible ... curved, or irregular surfaces. ,PFG: Flat ... Bellows cup ,PCG: Multiple Bellows cup ... from 25 to 200 mm , ...
Biology Products: