Navigation Links
UC San Diego engineer provides insights to decades-old DNA squabble
Date:7/31/2009

aborators suggest that the structure of chromatin is actually a combination of both of these models.

Some researchers suggest that its structure is like a solenoid, where the chain of nucleosomes follows a helical path along the chromatin axis such that adjacent nucleosomes along the chain lie side by side on the chromatin fiber also and thus the linker DNA connecting the two needs to maintain a highly bent conformation. Other researchers suggest that chromatin has a zigzag structure where the nucleosome chain follows a zigzag path along the chromatin fiber such that adjacent nucleosomes on the chain actually lie on opposite sides of the fiber such that the linker DNA is straight. (The nucleosome is the basic unit of chromatin that consists of two turns of DNA wrapped around a protein spool).

Arya and his team have developed a very sophisticated model of chromatin that is computationally accessible yet detailed enough to provide insights into its structure and dynamics. By simulating this model under physiological conditions using fast computer algorithms, Arya has provided the first evidence that chromatin does not exist uniquely in solenoid or zigzag forms but rather exhibits a "heteromorphic" structure where both types of structures are in balance with each other. Arya's collaborators have developed an innovative experimental approach called Electron microscopy assisted nucleosome capture technique to corroborate Arya's findings.

"What we did was extract the most important features of DNA and the associated proteins in the model, using techniques called coarse-graining," Arya explained. "You cannot simulate something as large as a chromatin fiber containing tens of nucleosomes at molecular detail for periods of time longer than a few nanoseconds. That will not tell you much. You need to reduce the complexity of the system without sacrificing important details, which is exactly what we have done. We're trying to reduce the total number o
'/>"/>

Contact: Andrea Siedsma
asiedsma@soe.ucsd.edu
858-822-0899
University of California - San Diego
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. UC San Diego physicists tackle knotty puzzle
2. UC-San Diego Engineering Honor Society wins most outstanding chapter award
3. Experimental Biology 2008 meets in San Diego April 5-9
4. UC San Diego begins trading greenhouse gas credits on Chicago Climate Exchange
5. San Diego Harbor Police Deploy BIO-key(R) Automated Vehicle Location System
6. Biologists at UC San Diego identify key protein in cells self-eating function
7. UC San Diego researchers eliminate drug discovery bottleneck
8. Glowing films developed by UC San Diego chemists reveal traces of explosives
9. UC San Diego researchers identify potential new drug candidates to combat bird flu
10. UC San Diego launches Institute of Engineering in Medicine to accelerate health care tech
11. UC San Diego researchers could help US military thwart explosive threats
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UC San Diego engineer provides insights to decades-old DNA squabble
(Date:8/20/2015)... Aug. 20, 2015 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market and ... joined The Smart Card Alliance and the EMV Migration ... and the Smart Card Alliance Latin America (SCALA) Chapter ... peers and thought leaders promoting adoption of smart card ...
(Date:8/18/2015)... Aug. 18, 2015  Navitas today announced ... to the Submission Content Management webinar scheduled ... non-profit forum. Dedicated to the Implementation of Regulatory ... platform for industry, vendors, health authorities, consultants ... work towards a standard method of implementing ...
(Date:8/17/2015)... OXFORD, Conn. , Aug. 17, 2015  NXT-ID, ... a biometric authentication company focused on the growing mobile ... announces its new sales campaign for Q4 2015. The ... winning marketing team consisting of Amplitude Marketing Group ( ... Amplitude Marketing Group is a leader in retail driven ...
Breaking Biology News(10 mins):NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 2NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 3NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 4Navitas, a Key Contributor in IRISS Forum Webinar 2Navitas, a Key Contributor in IRISS Forum Webinar 3NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3
... of the greatest mysteries of modern coral reefs is how ... has long existed in the record of coral evolution. ... in sea level and changes in the Earth,s climate between ... many "old" corals went extinct, and the modern reef corals ...
... the University of Alberta have made a discovery that may ... cow disease, adapt in order to spread between various types ... discovered that a miniscule change in the prions, makeup appears ... mimic and recreate new strains with which it comes into ...
... For hundreds of years, naturalists and scientists have ... differences. But now, new genetic techniques are revealing ... visible differences. In a just-published study, evolutionary ... the American Museum of Natural History (AMNH) combine ...
Cached Biology News:University of Miami geologists to address the mystery of an evolution gap in reef corals 2Discovery may explain how prion diseases spread between different types of animals 2Researchers develop tools for discovering new species 2Researchers develop tools for discovering new species 3
(Date:8/26/2015)... /PRNewswire/ - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ... the quarter ended June 30, 2015. Amounts, unless ... presented under International Financial Reporting Standards ("IFRS"). ... our Oral Amp B program, rapidly advancing towards ... Andrew Rae , President & CEO of iCo ...
(Date:8/26/2015)... 26, 2015 Intrexon Corporation (NYSE: XON ... closing of its previously announced public offering of common ... of their option to purchase an additional 731,707 shares ... $41.00 per share.  The exercise of the underwriters, option ... sold by Intrexon to 5,609,756 shares and increased the ...
(Date:8/26/2015)... San Bruno, CA. (PRWEB) , ... August 26, 2015 , ... ... three major conferences to develop new business relationships with local sponsors in southern California. ... services to facilitate their drug development processes and regulatory pathways., , ...
(Date:8/25/2015)... Aug. 25, 2015 Human Longevity, Inc. (HLI), the ... has joined the company as Chief Operating Officer. Winham, ... operations and technical experience, will report directly to HLI,s CEO, ... this new role as COO, Winham will be responsible for ... well as all facility operations. HLI currently has three locations ...
Breaking Biology Technology:iCo Therapeutics Announces Second Quarter 2015 Financial Results 2iCo Therapeutics Announces Second Quarter 2015 Financial Results 3Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 2Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 3Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 4PRC Clinical To Attend Major Industry Conferences And Meet Sponsor Companies In The San Diego Biotech Hub 2PRC Clinical To Attend Major Industry Conferences And Meet Sponsor Companies In The San Diego Biotech Hub 3Human Longevity, Inc. Hires Life Sciences Leader, Mark Winham, as Chief Operating Officer 2
... VIRGINIA BEACH, Va., Oct. 7, 2008 AMERIGROUP,Corporation ... will report its earnings,for the third quarter ended ... October 22, 2008. At 8:30 a.m. Eastern Time ... a conference call and webcast,to discuss earnings and ...
... of Lives, GERMANTOWN, Md., Oct. 7 ... development of medical,countermeasures for biodefense and emerging infectious ... for advanced development of a,vaccine to protect against ... Allergy and Infectious Diseases (NIAID), part of the ...
... Maryland, October 7 Orthocrat Ltd., announced,today ... purchased,TraumaCad(TM), a web-based pre-operative planning and digital ... used X-ray films and acetate,overlays to determine ... for,joint-replacement surgery. With the adoption of digital ...
Cached Biology Technology:AMERIGROUP Corporation to Discuss Third Quarter Earnings on October 23 2Integrated BioTherapeutics Awarded NIAID Contract For Up to $65 Million for Development of a Vaccine against Ebola and Marburg Viruses 2Integrated BioTherapeutics Awarded NIAID Contract For Up to $65 Million for Development of a Vaccine against Ebola and Marburg Viruses 3George Washington University Hospital Purchases Orthocrat's TraumaCad(TM) for Orthopedic Preoperative Planning 2George Washington University Hospital Purchases Orthocrat's TraumaCad(TM) for Orthopedic Preoperative Planning 3
...
... pAcGHLT-A,B,C Baculovirus ... Set,pAcGHLT-XylE Baculovirus ... Powder,Thrombin Dilution ... Cocktail,Insect Cell ...
...
... Plus accurately and conveniently controls the temperature at ... different temperature levels up to 99 C*, with ... as low as 5 C. The thermoblocks for ... tubes, and microplates enable a high degree of ...
Biology Products: