Navigation Links
UC San Diego bioengineers fill holes in science of cellular self-organization
Date:10/6/2008

The chemical and biological aspects of cellular self-organization are well-studied; less well understood is how cell populations order themselves biomechanically how their behavior and communication are affected by high density and physical proximity. Bioengineers and physicists at the University of California San Diego, in a paper published in the current issue of the Proceedings of the National Academy of Sciences, have begun to address these fundamental questions.

The UC San Diego scientists focused their research on dense colonies of the rod-shaped bacteria Escherichia coli. By analyzing the spatial organization of the bacteria in a microfluidic chemostat a kind of mini-circuit board for liquids rather than electrons they found that growth and expansion of a dense colony of cells leads to a dynamic change from relative disorder to a remarkable re-orientation and alignment of the rod-like cells.

That finding, described in their paper "Biomechanical Ordering of Dense Cell Populations," allowed them to develop a model of collective cell dynamics, and to use this model to "elucidate the mechanism of cell ordering, and quantify the relationship between the dynamics of cell proliferation and the spatial structure of the population."

One of the authors, Lev S. Tsimring, at UC San Diego's Institute of Nonlinear Science, explained the bioengineers' use of bacteria to study the biomechanical ordering of cells.

"When environmental conditions are harsh, bacteria like to stick together. The most typical form of bacterial organization in nature is a biofilm: a dense quasi-two-dimensional colony of bacteria. Biofilms grow in and on living tissues, the surfaces of rocks and soils, and in aquatic environments," he said, "but they're also found in man-made systems and devices such as industrial piping and artificial implants. And bacteria are known to actively migrate toward surfaces and small cavities, where they form high-density colonies."

At low densities, he said, bacteria and other cells communicate "remotely" by sending chemical signals "chemotaxis" but, as they aggregate and form dense communities, direct biomechanical contacts play a bigger and bigger role in how they organize themselves.

"Although previous studies have explored the complex signaling mechanisms in the early stages of biofilm formation," Tsimring said, "the biomechanics of direct cellular contacts have received little attention. We focused, therefore, on the structure and dynamics of a growing two-dimensional colony of non-motile bacteria."

His fellow researcher, Jeff Hasty, at the Institute for Nonlinear Science and UC San Diego's Department of Bioengineering, said the team's work provides a multiscale description of cell colony growth.

"Our results reveal how cell growth and colony expansion trigger the formation of the orientational order in the population," Hasty said, "which, in turn, affects the mechanical and biochemical properties of the colony."

The details of their research, the authors say, helps scientists understand how the local interaction of elementary components leads to collective behavior and the formation of a highly organized system.


'/>"/>

Contact: Paul K. Mueller
ltsimring@ucsd.edu
858-534-8564
University of California - San Diego
Source:Eurekalert  

Related biology news :

1. UC San Diego physicists tackle knotty puzzle
2. UC-San Diego Engineering Honor Society wins most outstanding chapter award
3. Experimental Biology 2008 meets in San Diego April 5-9
4. UC San Diego begins trading greenhouse gas credits on Chicago Climate Exchange
5. San Diego Harbor Police Deploy BIO-key(R) Automated Vehicle Location System
6. Biologists at UC San Diego identify key protein in cells self-eating function
7. UC San Diego researchers eliminate drug discovery bottleneck
8. Glowing films developed by UC San Diego chemists reveal traces of explosives
9. UC San Diego researchers identify potential new drug candidates to combat bird flu
10. UC San Diego launches Institute of Engineering in Medicine to accelerate health care tech
11. UC San Diego researchers could help US military thwart explosive threats
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UC San Diego bioengineers fill holes in science of cellular self-organization
(Date:4/5/2017)... YORK , April 5, 2017 Today ... is announcing that the server component of the HYPR ... known for providing the end-to-end security architecture that empowers ... HYPR has already secured over 15 million ... makers including manufacturers of connected home product suites and ...
(Date:3/30/2017)... March 30, 2017  On April 6-7, 2017, Sequencing.com ... Genome hackathon at Microsoft,s headquarters in ... will focus on developing health and wellness apps that ... Hack the Genome is the first hackathon for ... world,s largest companies in the genomics, tech and health ...
(Date:3/28/2017)... 28, 2017 The report "Video ... Monitors, Servers, Storage Devices), Software (Video Analytics, VMS), and ... Global Forecast to 2022", published by MarketsandMarkets, the market ... is projected to reach USD 75.64 Billion by 2022, ... The base year considered for the study is 2016 ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... , Aug. 15, 2017 After spending the past two ... with crowdsourced data collection, GeneFo now offers this platform to healthcare ... and amplifying support, adherence, and data collection vis a vis their ... mark the successful launch of this offer. ... GeneFo ...
(Date:8/15/2017)... ... August 15, 2017 , ... Kenall, a leader in ... to stay tightly sealed and perform efficiently for years. The downlights are ideal ... just aren't enough, such as: hospitals; behavioral health facilities; cleanrooms; containment areas; food ...
(Date:8/14/2017)... Portland, Oregon (PRWEB) , ... August 14, 2017 ... ... modules that provide essential device-to-computer interconnect using USB or PCI Express, announced the ... hardware. , SYZYGY is intended to satisfy the need for a compact, low ...
(Date:8/11/2017)... ... August 11, 2017 , ... ... and, in particular, more natural alternatives to synthetic ingredients,” said Matt Hundt, President ... Wave, with the established manufacturing presence and know-how of Biorigin will allow us ...
Breaking Biology Technology: