Navigation Links
UC Riverside neuroscientists' discovery could bring relief to epilepsy sufferers
Date:6/21/2011

RIVERSIDE, Calif. Researchers at the University of California, Riverside have made a discovery in the lab that could help drug manufacturers develop new antiepileptic drugs and explore novel strategies for treating seizures associated with epilepsy a disease affecting about two million Americans.

Neurons, the basic building blocks of the nervous system, are cells that transmit information by electrical and chemical signaling. During epileptic seizures, which generally last from a few seconds to minutes and terminate spontaneously, the concentrations of ions both inside the neuron and the space outside the neuron change due to abnormal ion flow to and from neurons through ion "channels" tiny gateways that are embedded to the surface of the neuron.

Ordinarily, intracellular (inside the cell) sodium concentration is low compared to extracellular sodium (the reverse is true of potassium). During seizure, however, there is a buildup of intracellular sodium, with sodium ions moving into neurons from the extracellular space, and potassium ions doing the opposite.

To understand exactly how neurons function during epileptic seizures, Maxim Bazhenov, an associate professor of cell biology and neuroscience, and Giri P. Krishnan, a postdoctoral researcher in his lab, developed and used realistic computer simulations in their analyses and found that while there is a progressive and slow increase in intracellular sodium during seizure, it is this accumulation of intracellular sodium that leads to the termination of the seizure.

"According to our model, sodium concentration reaches a maximum just before the seizure terminates," Bazhenov said. "After seizure initiation, this intracellular sodium buildup is req
'/>"/>

Contact: Iqbal Pittalwala
iqbal@ucr.edu
951-827-6050
University of California - Riverside
Source:Eurekalert  

Page: 1 2

Related biology news :

1. UC Riverside biochemists devise method for bypassing aluminum toxicity effects in plants
2. Vitamin D a key player in overall health of several body organs, says UC Riverside biochemist
3. UC Riverside scientist to explore how vegetation affects urban heat islands
4. UC Riverside rice geneticist receives high honor from US Department of Agriculture
5. UC Riverside biochemist to study how crops can increase protein production
6. UC Riverside researcher names lichen after President Barack Obama
7. UC Riverside professor receives top scientific honor
8. UC Riverside geneticist receives highest honor from Botanical Society of America
9. Public lecture at UC Riverside to discuss origin and fate of universe
10. UC Riverside student is 1 of only 5 persons selected for challenging Arctic expedition
11. UC Riverside research on barley genome gets boost from $1 million USDA grant
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UC Riverside neuroscientists' discovery could bring relief to epilepsy sufferers
(Date:5/21/2013)... "place" is increasingly being considered in the management ... new resource that can help them recognize and ... places in their lives. , Place-Based Conservation: ... co-edited by the Pacific Northwest Research Station,s Linda ... to conservation. The book is published by Springer ...
(Date:5/21/2013)... become most deadly when they metastasize and spread tumors ... it becomes very difficult for doctors to locate and ... at the University of Missouri have found a way ... wherever they may be in the body. Michael Lewis, ... of Veterinary Medicine, says being able to target secondary ...
(Date:5/21/2013)... largest scientific society, invites news media coverage of ... 2013, in Indianapolis, Ind. It will take place ... hotels. , With more than 7,100 presentations on ... astronomy to zoology ― the meeting will offer ... of spot news and feature possibilities. The topics ...
Breaking Biology News(10 mins):MU researchers develop radioactive nanoparticles that target cancer cells 2
... with genetic risk of bowel cancer has found that ... of insurance implications. "This indicates that people have ... decision to have potentially life saving genetic testing," says ... Melbourne,s Key Centre for Women,s Health in Society. ...
... mayapple may soon offer an alternative to an Asian ... its anti-cancer properties. The near-extinct Asian plant, Podophyllyum ... etoposide, the active ingredient in a drug used for ... is a cousin of the common mayapple weed found ...
... This is the conclusion of a study which has analyzed the ... 14 years. The decrease in this activity and the fall in ... 10%) are the reasons why the "war", in the sense of ... Researchers from the Mediterranean Institute for Advanced Studies (IMEDEA-CSIC) ...
Cached Biology News:Fear of insurance rejection deters potentially life saving genetic tests for bowel cancer 2Anticancer compound found in American mayapple 2The war against wildlife comes to an end in Southern Europe 2
(Date:5/22/2013)... Genedata, a leading provider of ... and life science research, today announced AB Enzymes ... its bioinformatics platform for strain genome data management ... AB Enzymes, one of the world’s oldest and ... Genedata Selector accompanied by bioinformatics consulting services. Genedata ...
(Date:5/22/2013)... May 22, 2013 Mold remediation could take ... that there is a way to cut down the process' ... its latest post the details of a method how ... , Mold could be prevented, My Cleaning Products said. But ... stated that a mold remediation must then be promptly implemented ...
(Date:5/22/2013)... 2013 Envera announced today that Michael ... Mr. McErlean has an extensive background in cell production ... his career. , Mike Matheny, President and ... have Mike join our team”. “Mike’s background is perfectly ... fermentation and downstream processing equipment”, added Matheny. “Mike’s ...
(Date:5/22/2013)... 22, 2013  Moderna Therapeutics, the pioneering company developing ... enable the in vivo production of therapeutic ... will join Moderna in early July as its ... a proven leader in the design and implementation of ... discovery to translation, clinical operations and commercial preparedness. John ...
Breaking Biology Technology:AB Enzymes Chooses Genedata Selector for Production Strain Development and Optimization 2AB Enzymes Chooses Genedata Selector for Production Strain Development and Optimization 3AB Enzymes Chooses Genedata Selector for Production Strain Development and Optimization 4How to Kill Mold While Saving Thousands of Dollars on Mold Remediation Projects Explained by My Cleaning Products 2Envera Appoints Michael McErlean Fermentation Manager 2Industry Leader John Reynders Joins Moderna Therapeutics as Chief Information Officer 2Industry Leader John Reynders Joins Moderna Therapeutics as Chief Information Officer 3
... of Complex Arrhythmias Achieved Approval Considered ... Jan. 15 Stereotaxis, Inc. (Nasdaq:,STXS) announced today ... U.S. Food,and Drug Administration (FDA) has approved its ... ablation in the United States., "The long-awaited ...
... Detail Latest Cardiac Surgery Technology to be Held ... January 26th at 6:30 p.m. Eastern ... technology companies will host the first annual After Hours Event,on ... the yacht,"Princess Lady." The invitation-only event, immediately preceding the,largest meeting ...
... response to the,Federal Drug Administration,s announcement today that ... consumption, Smithfield Foods, Inc.,(NYSE: SFD ) reiterated ... produce meat products from cloned animals. The science ... leaders in our industry,we will continue to monitor ...
Cached Biology Technology:Stereotaxis Announces FDA Approval of Its Partnered Magnetic Irrigated Catheter 2Stereotaxis Announces FDA Approval of Its Partnered Magnetic Irrigated Catheter 3Five Medical Technology Companies Host Premier Event for Cardiothoracic Surgeons 2Five Medical Technology Companies Host Premier Event for Cardiothoracic Surgeons 3Five Medical Technology Companies Host Premier Event for Cardiothoracic Surgeons 4
RABBIT ANTI HUMAN CHYMOTRYPSIN...
MSE ANTI CAN. CD3:FITC/RAT ANTI CD4:RPE...
MOUSE ANTI POLY (ADP-RIBOSE) Immunogen: Purified poly (ADP-ribose) polymer, 10-50 unit chain length...
... et.al. (1997) • Contains short ... biochemistry & molecular biology, arranged ... Entries give details of biochemical ... which they are involved and ...
Biology Products: