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UC Irvine scientists find new way to sort stem cells
Date:12/20/2007

stem.

In this study, the scientists wanted to identify and collect stem cells that were destined to become neurons, which are cells in the brain and spinal cord that process and transmit information. Neurons that die as a result of injury or disease do not regenerate, which is why people with neuronal loss suffer problems such as paralysis and memory loss. Scientists believe that stem cell transplantations might be able to restore part of the lost function.

With the goal of identifying future neurons, UCI engineers built a tiny device using a glass slide to perform the dielectrophoresis. First, scientists place unsorted mouse stem cells on one side of the device. The cells then float in sugar water through a tiny channel past electrodes set to a particular frequency. At a certain frequency, stem cells destined to become neurons will stick to the electrodes while other cells pass by. The cells that stick then can be removed and grouped together, potentially for use in a therapy.

Currently, stem cells most often are separated using a machine called a fluorescence-activated cell sorter (FACS). FACS machines, which use lasers to detect the light scattering and fluorescent characteristics of the cells, can weigh hundreds of pounds and cost $500,000 or more. The UCI-designed dielectrophoresis device is just a fraction of the size and cost. The two devices could be used to complement each other to create ultra pure stem cell populations.

Once the mold is created, these sorts of devices can cost just pennies to make, said Ed Monuki, senior author and UCI developmental biologist. You could have many for every member of your lab and it wouldnt be prohibitively expensive.

A strong collaborative partnership between UCI biologists and engineers made this discovery possible. With input from biologists, engineers built the device in UCIs Integrated Nanosystems Research Facility. This represents truly an interdisciplinary effort that ex
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Contact: Jennifer Fitzenberger
jfitzen@uci.edu
949-824-3969
University of California - Irvine
Source:Eurekalert

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