Navigation Links
UC Irvine scientists find new way to sort stem cells
Date:12/20/2007

Irvine, Calif., Dec. 20, 2007 UC Irvine scientists have found a new way to sort stem cells that should be quicker, easier and more cost-effective than current methods. The technique could in the future expedite therapies for people with conditions ranging from brain and spinal cord damage to Alzheimers and Parkinsons diseases.

The method uses electrodes on a tiny, inch-long glass slide to sort cells by their electric charges and has been used in cancer research. The stem cell field suffers from a lack of tools for identifying and sorting cells. This important discovery could add a new tool to current sorting methods, which generally require expensive, bulky equipment.

For therapeutic purposes, we want stem cells to turn into specific cell types once they have been transplanted. The trick to doing this is identifying beforehand which cells will become the desired cell type, such as a neuron, said Lisa Flanagan, lead author of the study and a stem cell biologist at UCI. We have discovered a new, potentially better way to do this by focusing on the electric properties of the cells.

This study appears online Dec. 20 in the journal Stem Cells.

The technique used by the scientists, called dielectrophoresis, is based on the premise that different types of cells have different electric properties. Stem cells that are destined to become neurons, for example, have a different electric charge than stem cells that will become astrocytes, another type of brain cell. The scientists discovered that the cells react differently when electric fields are applied. At one frequency, a neuron will be attracted to an electrode but an astrocyte will not, and at a different frequency, an astrocyte will be attracted but a neuron will not.

Identifying and sorting stem cells is important when creating stem cell-based therapies. Without a purification process, stem cell transplantations can cause tumors or be rejected by the bodys immune sy
'/>"/>

Contact: Jennifer Fitzenberger
jfitzen@uci.edu
949-824-3969
University of California - Irvine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UC Irvine receives $2.18M to explore nano advancements in DNA sequencing
2. UK scientists working to help cut ID theft
3. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
4. Comet probes reveal evidence of origin of life, scientists claim
5. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
6. Male elephants get photo IDs from scientists
7. Scientists retrace evolution with first atomic structure of an ancient protein
8. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
9. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
10. Clemson scientists shed light on molecules in living cells
11. Scientists tackle mystery mountain illness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... Buenos Aires yesterday, Argentina joins the European Molecular ... The move strengthens the ties between the European ... Argentinian scientists access to EMBL,s world-class facilities and ... since its inception, fostering excellent life science research ... core of EMBL,s mission," says EMBL Director General ...
(Date:4/23/2014)... Heidelberg, 23 April 2013 EMBO today announced Sophie ... winner of the 2014 EMBO Gold Medal. The award ... define the organization and development of the cell. , ... to understand cellular polarity, in particular the way in ... size and cell division. In the last 11 years, ...
(Date:4/23/2014)... researcher has shed light on how an estimated one ... outback have become reviled as pests and culled on ... and Sustainability Institute at the University of Exeter,s Penryn ... from their historic role helping to create the country,s ... , The deserts of the Australian outback are a ...
Breaking Biology News(10 mins):EMBO Gold Medal 2014 awarded to Sophie Martin 2How Australia got the hump with 1 million feral camels 2How Australia got the hump with 1 million feral camels 3
... a colorblind animal know how to change its skin ... the animal,s predator "see," looking at its prey before ... addressed in article published today by a collaborative team ... Mass., and the U.S. Military Academy in West Point, ...
... Protein Could Prove Powerful Target for Cholesterol Lowering Drugs ... have a profound effect on cholesterol metabolism. That discovery ... be a powerful target for cholesterol-lowering drugs, says corresponding ... and the University of California, Los Angeles. The research ...
... Most people don,t think worms are cool. But the ... do something very cool indeed: it can regenerate itself from ... it becomes two worms. This amazing ability of the ... wedge of tissue has fascinated scientists since the late 1800s. ...
Cached Biology News:How can a colorblind animal change its colors to blend into the background? 2How can a colorblind animal change its colors to blend into the background? 3Tips from the journals of the American Society for Microbiology 2Tips from the journals of the American Society for Microbiology 3Tips from the journals of the American Society for Microbiology 4Tips from the journals of the American Society for Microbiology 5Tips from the journals of the American Society for Microbiology 6Heads or tails? 2Heads or tails? 3
(Date:1/15/2014)... is the device," Nobel laureate Herbert Kroemer famously ... found at the junctures where layers of different ... the interfaces between layers of metal oxides are ... favorites as spintronics, high-temperature superconductors, ferroelectrics and multiferroics. ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 Cynvenio, a ... management through the genomic analysis of tumor cells in ... Finder™, a web-based cancer decision support application powered by ... with Cynvenio’s ClearID™ genomic test, Therapy Finder will provide ...
(Date:1/15/2014)... More than 5 million Americans are ... 3 seniors will die with Alzheimer’s or another dementia, ... have shocked many Americans into looking for ways to ... tragic age-related cognitive disorders. Jonathan Weisman, president of Biohack ...
(Date:1/15/2014)... 2014 Freeslate, Inc ., the ... that Lupin Limited, one of India’s top five pharmaceutical ... PharmD System for high throughput solid form screening. ... on a wide range of quality, affordable generic and ...
Breaking Biology Technology:A deeper look at interfaces 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3
... 2011 Cephalon, Inc., (Nasdaq: CEPH ) will hold ... founder and late Chairman and CEO on February 1, 2011, at ... Street, Philadelphia, Pennsylvania. Dr. Baldino founded Cephalon in ... one of the top ten biotechnology companies in the world. He ...
... Calif., Jan. 24, 2011 Genesis Biopharma, Inc. (OTC ... company developing targeted cancer therapies, today announced the ... for Industry Codevelopment of Two or More Unmarketed ... document, designed to encourage companies to collaborate and ...
... Leading organizations understand the value of using market research ... numerous functions. As pharmaceutical, biotechnology and medical device companies ... and develop new capabilities while refining current ones to ... The Future of Market Research: Challenges and Changes in ...
Cached Biology Technology:Cephalon to Hold Public Memorial Service to Celebrate the Life of Company Founder, Frank Baldino, Jr., Ph.D. 2Genesis Biopharma Expresses Support for FDA Codevelopment Guidelines 2Role of Market Research Evolving to Take on a More Strategic Responsibility 2
...
...
Removes polysaccharide and phenolic inhibitors of PCR; yields DNA greater than 50 kb in length...
Sf9 Insect Cells (Frozen) in Max-XP Medium...
Biology Products: