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UC Irvine receives $2.18M to explore nano advancements in DNA sequencing
Date:10/1/2007

and human genomics coordinator for the Institute for Genomics and Bioinformatics, to integrate nanotechnology with a Nobel Prize-winning DNA sequencing method developed in 1975 by Frederick Sanger.

The process will employ a novel DNA separation method using the atomic force microscope (AFM), a Wickramasinghe invention. Researchers will then decode the DNA sequence with the help of light concentrated at a probe that is about 50 atoms wide at its tip.

It will take substantially less time to sort, analyze and then map DNA using this technique, since the procedure operates on a much smaller scale than the conventional Sanger method.

This new process has the capability to produce accurate results that are both 10,000 times faster and less expensive to obtain, since many of the expenses related to current methods of sequencing DNA are tied to the time it takes and the large amount of chemicals used.

Applying nanotechnology techniques to fundamental DNA sequencing methods allows nano pioneers like Professor Wickramasinghe the platform to contribute new advances that will directly affect the well-being and health of society, said Nicolaos G. Alexopoulos, dean of The Henry Samueli School of Engineering. The school is excited to participate in this effort that will help advance the medical field and aid health care professionals in proactively diagnosing and better treating their patients.


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Contact: Jason Mednick
jmednick@uci.edu
949-824-5951
University of California - Irvine
Source:Eurekalert

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